anti-TMPRSS6 (TMPRSS6) Antikörper

Bezeichnung:
anti-Transmembrane Protease, serine 6 Antikörper (TMPRSS6)
Auf www.antikoerper-online.de finden Sie aktuell 42 Transmembrane Protease, serine 6 (TMPRSS6) Antikörper von 10 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen TMPRSS6 Kits (11) und TMPRSS6 Proteine (6) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 62 TMPRSS6 Produkte verfügbar.
Synonyme:
1300008A22Rik, IRIDA
Alle Antikörper anzeigen Gen GeneID UniProt
TMPRSS6 315388  
TMPRSS6 164656 Q8IU80
TMPRSS6 71753 Q9DBI0

Alle Spezies anzeigen

Weitere Synonyme anzeigen

Meistgesuchte Reaktivitäten zu anti-TMPRSS6 (TMPRSS6) Antikörper

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anti-Rat (Rattus) TMPRSS6 Antikörper:

anti-Human TMPRSS6 Antikörper:

anti-Mouse (Murine) TMPRSS6 Antikörper:

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Am meisten referenzierte anti-TMPRSS6 Antikörper

  1. Human Polyclonal TMPRSS6 Primary Antibody für WB - ABIN1881891 : Altamura, DAlessio, Selle, Muckenthaler: A novel TMPRSS6 mutation that prevents protease auto-activation causes IRIDA. in The Biochemical journal 2010 (PubMed)
    Zeige alle 2 Referenzen für 1881891

  2. Cow (Bovine) Polyclonal TMPRSS6 Primary Antibody für IHC, WB - ABIN2785278 : Finberg, Heeney, Campagna, Aydinok, Pearson, Hartman, Mayo, Samuel, Strouse, Markianos, Andrews, Fleming: Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA). in Nature genetics 2008 (PubMed)

Weitere Antikörper gegen TMPRSS6 Interaktionspartner

Human Transmembrane Protease, serine 6 (TMPRSS6) Interaktionspartner

  1. In examining iron variant associations with glucose homeostasis, an iron-raising variant of TMPRSS6 was associated with lower HbA1c levels (P = 8.66 x 10-10).

  2. Studies in colonic T84 cell monolayers revealed that barrier disruption by the colitis-associated Th2-type cytokines, IL-4 (zeige IL4 Antikörper) and IL-13 (zeige IL13 Antikörper), down-regulates matriptase (zeige ST14 Antikörper) as well as prostasin (zeige PRSS8 Antikörper) through phosphorylation of the transcriptional regulator STAT6 (zeige STAT6 Antikörper)

  3. TMPRSS6 gene sequencing in 20 cases with IRIDA phenotype revealed 9 potentially deleterious intronic and two benign exonic variations in 12/20 cases (60%).

  4. Study suggests that deregulated pericellular matriptase (zeige ST14 Antikörper) activity in OSCC may transactivate PAR-2 (zeige F2RL1 Antikörper) on fibroblasts in the surrounding tissue and thus promote their recruitment to the perimeter of the tumor, contributing to a microenvironement that favors tumor growth of oral squamous cell carcinoma.

  5. All cases were either homozygous or compound heterozygous for missense or frameshift mutations in the TMPRSS6 gene, 2 of the mutations being novel (Cys410Ser and Leu689Pro)

  6. TMPRSS6 expression is significantly downregulated in human masticatory mucosa during wound healing

  7. Matriptase-2 deficiency causes iron deficiency anemia during the early postnatal development, but not during fetal development in humans.

  8. Iron refractory iron deficiency anemia is caused by mutations of TMPRSS6 which encodes matriptase-2, a serine protease (zeige F2 Antikörper) expressed on cell membranes of hepatocytes which is involved in the hepcidin (zeige HAMP Antikörper) regulatory pathways by processing hemojuvelin (zeige HFE2 Antikörper) protein.

  9. Combination of Tmprss6- ASO and the iron chelator deferiprone improves erythropoiesis and reduces iron overload in a mouse model of beta-thalassemia intermedia.

  10. Data show that p.V736A TMPRSS6 variant (rs855791) influences the susceptibility to hepatic iron accumulation in NTDT patients, and the risk allele is 736(A).

Mouse (Murine) Transmembrane Protease, serine 6 (TMPRSS6) Interaktionspartner

  1. Studies in colonic T84 cell monolayers revealed that barrier disruption by the colitis-associated Th2-type cytokines, IL-4 (zeige IL4 Antikörper) and IL-13 (zeige IL13 Antikörper), down-regulates matriptase (zeige ST14 Antikörper) as well as prostasin (zeige PRSS8 Antikörper) through phosphorylation of the transcriptional regulator STAT6 (zeige STAT6 Antikörper)

  2. the function of matriptase-2 is dominant over that of ERFE and is essential in facilitating hepcidin (zeige HAMP Antikörper) suppression by attenuating the BMP-SMAD (zeige SMAD1 Antikörper) signaling.

  3. role of fetuin-A (zeige AHSG Antikörper) in iron homeostasis and provide new insights into the mechanism of how matriptase-2 might modulate hepcidin (zeige HAMP Antikörper) expression

  4. TMPRSS6 inhibition via decreased STAT5 (zeige STAT5A Antikörper) phosphorylation may be an additional mechanism by which inflammation stimulates hepcidin (zeige HAMP Antikörper) expression to regulate iron homeostasis and immunity.

  5. matriptase-2 (encoded by Tmprss6)-is responsible for hepcidin (zeige HAMP Antikörper) repression throughout development, with its deficiency leading to increased hepcidin (zeige HAMP Antikörper) levels triggering iron deficiency and anemia starting in utero

  6. The iron-regulatory serine protease (zeige F2 Antikörper) matriptase-2 is expressed in the retina, and absence of this enzyme leads to iron deficiency.

  7. Loss of matriptase-2 increases bone morphogenetic protein-dependent signaling, while paradoxically decreasing liver hemojuvelin (zeige HFE2 Antikörper) protein content.

  8. Results confirm the anti-inflammatory status of Tmprss6 KO mice and identify new potential target pathways/genes of Tmprss6.

  9. Tmprss6 gene knockdown reduces iron overload in an animal model of hemochromatosis (zeige HFE Antikörper) and improves both iron overload and anemia in mice affected by beta-thalassemia.

  10. Double mutant mice lacking functional Hfe (zeige HFE Antikörper) or Tfr2 (zeige TFR2 Antikörper) and Tmprss6 exhibited a severe iron deficiency microcytic anemia phenotype mimicking the phenotype of single mutant mice lacking functional Tmprss6 demonstrating that Hfe (zeige HFE Antikörper) and Tfr2 (zeige TFR2 Antikörper) are not substrates for Tmprss6.

TMPRSS6 Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene is a type II transmembrane serine proteinase that is found attached to the cell surface. The encoded protein may be involved in matrix remodeling processes in the liver.

Alternative names and synonyms associated with TMPRSS6

  • transmembrane protease, serine 6 (Tmprss6) Antikörper
  • transmembrane protease, serine 6 (TMPRSS6) Antikörper
  • transmembrane serine protease 6 (Tmprss6) Antikörper
  • 1300008A22Rik Antikörper
  • IRIDA Antikörper

Bezeichner auf Proteinebene für TMPRSS6

transmembrane protease serine 6 , transmembrane serine protease 6 , matriptase-2 , membrane-bound mosaic serine proteinase matriptase-2 , type II transmembrane serine protease 6 , matriptase 2 , transmembrane protease, serine 6

GENE ID SPEZIES
315388 Rattus norvegicus
164656 Homo sapiens
614844 Bos taurus
71753 Mus musculus
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