RAP1A Proteine (RAP1A)

Bezeichnung:
RAP1A, Member of RAS Oncogene Family Proteine (RAP1A)
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Synonyme:
AI848598, G-22K, Krev-1, KREV1, RAP-1A, Rap1, rap 1A, SMGP21, wu:fc66g06, zgc:86676
alle Proteine anzeigen Gen GeneID UniProt
RAP1A 5906 P62834
RAP1A 295347 P62836
RAP1A 109905 P62835

Weitere Synonyme anzeigen

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Am meisten referenzierte RAP1A Proteine

  1. Human RAP1A Protein expressed in Escherichia coli (E. coli) - ABIN667792 : Han, Colicelli: A human protein selected for interference with Ras function interacts directly with Ras and competes with Raf1. in Molecular and cellular biology 1995 (PubMed)
    Zeige alle 2 Referenzen für 667792

  2. Human RAP1A Protein expressed in Wheat germ - ABIN1317390 : Chu, Awasthi, White, Chrzanowska-Wodnicka, Malarkannan: Rap1b regulates B cell development, homing, and T cell-dependent humoral immunity. in Journal of immunology (Baltimore, Md. : 1950) 2008 (PubMed)
    Zeige alle 2 Referenzen für 1317390

Weitere Proteine zu RAP1A Interaktionspartnern

Zebrafish RAP1A, Member of RAS Oncogene Family (RAP1A) Interaktionspartner

  1. RAP1 (zeige TERF2IP Proteine)-mediated MEK (zeige MAP2K1 Proteine)/ERK (zeige MAPK1 Proteine) pathway defects in Kabuki syndrome.

Human RAP1A, Member of RAS Oncogene Family (RAP1A) Interaktionspartner

  1. High RAP1 (zeige RABGEF1 Proteine) expression is associated with neuroblastoma (zeige ARHGEF16 Proteine).

  2. Rap1 mediates the effects of increased extracellular tension in multiple ways that are capable of contributing to tumor progression when dysregulated.

  3. Novel mutations in RASGRP2, which encodes CalDAG-GEFI, abrogate Rap1 activation, causing platelet dysfunction

  4. Unlike Rap1B (zeige RAP1B Proteine), phosphorylation in the polybasic region of Rap1A does not detectably inhibit its prenylation or its binding to SmgGDS (zeige RAP1GDS1 Proteine)-607.

  5. SHANK1 and SHANK3 act as integrin activation inhibitors by sequestering active Rap1 (zeige RABGEF1 Proteine) and R-Ras via the SPN (zeige SPN Proteine) domain and thus limiting their bioavailability at the plasma membrane.

  6. These results suggest that Rap1 (zeige RABGEF1 Proteine) activation of ERKs requires PKA phosphorylation and KSR (zeige KSR1 Proteine) binding.

  7. These data suggested that HBV-infection could up-regulate the expression of miR (zeige MLXIP Proteine)-203a, thus down regulated the expression of Rap1a.

  8. Studies indicate that Rap (zeige LRPAP1 Proteine) interacting proteins decide the subcellular localization of Rap (zeige LRPAP1 Proteine), and the interaction modes with downstream Rap (zeige LRPAP1 Proteine) effectors.

  9. A receptor type-protein tyrosine phosphatase alpha-Src family kinase-Rap1 pathway was identified as responsible for recruiting myosin IIB to the zonula adherens in epithelial cells and supporting contractile tension.

  10. Rap1 (zeige RABGEF1 Proteine)- and Rac1-GTPase (zeige RACGAP1 Proteine) activation have roles in hypoxia/reoxygenation-experienced cancer cell migration and metastasis via the expression of thymosin beta-4 (zeige TMSB4X Proteine)

Cow (Bovine) RAP1A, Member of RAS Oncogene Family (RAP1A) Interaktionspartner

  1. Rap1 (zeige TERF2IP Proteine) increases KRIT-1 (zeige KRIT1 Proteine) targeting to endothelial cell-cell junctions where it suppresses stress fibers and stabilizes junctional integrity.

Mouse (Murine) RAP1A, Member of RAS Oncogene Family (RAP1A) Interaktionspartner

  1. the Rap1-cofilin-1 pathway coordinates actin and microtubule organization at the immune synapse.

  2. Rap1 mediates the effects of increased extracellular tension in multiple ways that are capable of contributing to tumor progression when dysregulated.

  3. Results from comparative proteomics identified Rap1 as a novel legionella-containing-vacuole host component implicated in intracellular replication of Legionella pneumophila.

  4. These results suggest that Rap1 (zeige TERF2IP Proteine) activation of ERKs requires PKA phosphorylation and KSR (zeige KSR1 Proteine) binding.

  5. the interaction between nephrin and MAGI-1 regulates Rap1 activation in podocytes to maintain long term slit diaphragm structure

  6. These findings ascribe a new function to SLAT, and identify Rap1 as a target of SLAT function in TCR-mediated inside-out signaling.

  7. Rap1 Is Essential for Mouse Development and Formation of Functional Vasculature

  8. Rap1 deficiency impaired T-cell homeostasis.

  9. Rap1 promotes endothelial mechanosensing complex formation, NO release and normal endothelial function

  10. these data show that Treg degrade ATP to adenosine via CD39, attracting DC by activating Epac1-Rap1-dependent pathways.

RAP1A Protein Überblick

Protein Überblick

The product of this gene belongs to the family of RAS-related proteins. These proteins share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. The product of this gene counteracts the mitogenic function of RAS because it can interact with RAS GAPs and RAF in a competitive manner. Two transcript variants encoding the same protein have been identified for this gene.

Alternative names and synonyms associated with RAP1A

  • RAP1A, member of RAS oncogene family (LOC100338584)
  • RAP1A, member of RAS oncogene family (LOC100351588)
  • RAP1A, member of RAS oncogene family (rap1a)
  • RAP1A, member of RAS oncogene family (RAP1A)
  • RAP1A, member of RAS oncogene family (Rap1a)
  • RAS-related protein-1a (Rap1a)
  • AI848598 Protein
  • G-22K Protein
  • Krev-1 Protein
  • KREV1 Protein
  • RAP-1A Protein
  • Rap1 Protein
  • rap 1A Protein
  • SMGP21 Protein
  • wu:fc66g06 Protein
  • zgc:86676 Protein

Bezeichner auf Proteinebene für RAP1A

RAP1A, member of RAS oncogene family , Rap1b , ras-related protein Rap-1A , C21KG , G-22K , GTP-binding protein smg p21A , RAS-related protein RAP1A , Ras-related protein Krev-1 , RAS-related protein 1a , ras-related protein Krev-1 , GTP-binding protein smg-p21A , GTP-binding protein SMG-P21A

GENE ID SPEZIES
100338584 Oryctolagus cuniculus
100351588 Oryctolagus cuniculus
415242 Danio rerio
779127 Xenopus laevis
419867 Gallus gallus
5906 Homo sapiens
101115080 Ovis aries
295347 Rattus norvegicus
282031 Bos taurus
109905 Mus musculus
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