anti-FYB (FYB) Antikörper

Bezeichnung:
anti-FYN-Binding Protein Antikörper (FYB)
Auf www.antikoerper-online.de finden Sie aktuell 91 FYN-Binding Protein (FYB) Antikörper von 20 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen FYB Proteine (4) und FYB Kits (2) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 108 FYB Produkte verfügbar.
Synonyme:
ADAP, B630013F22Rik, fyb, FYB-120/130, p120/130, p120/p130, PRO0823, RGD1563421, SLAP-130, Slap130

Meistgesuchte Reaktivitäten zu anti-FYB (FYB) Antikörper

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anti-Human FYB Antikörper:

anti-Mouse (Murine) FYB Antikörper:

anti-Rat (Rattus) FYB Antikörper:

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Am meisten referenzierte anti-FYB Antikörper

  1. Human Monoclonal FYB Primary Antibody für IF, WB - ABIN968265 : da Silva, Li, de Vera, Canto, Findell, Rudd: Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production. in Proceedings of the National Academy of Sciences of the United States of America 1997 (PubMed)
    Zeige alle 4 Referenzen für 968265

  2. Human Polyclonal FYB Primary Antibody für EIA, WB - ABIN952408 : Lehmann, Meyer, Schuemann, Krause, Freund: A novel S3S-TAP-tag for the isolation of T-cell interaction partners of adhesion and degranulation promoting adaptor protein. in Proteomics 2009 (PubMed)
    Zeige alle 3 Referenzen für 952408

Weitere Antikörper gegen FYB Interaktionspartner

Human FYN-Binding Protein (FYB) Interaktionspartner

  1. A distinct set of proteins interaction partners required for chemokine (zeige CCL1 Antikörper)-directed T cell migration is attracted by phosphotyrosine 571 of ADAP, including ZAP70 (zeige ZAP70 Antikörper).

  2. Data strongly suggest that chemokine-stimulated associations between Vav1, SLP-76, and ADAP facilitate Rac1 activation and alpha4beta1-mediated adhesion, whereas Pyk2 opposes this adhesion by limiting Rac1 activation.

  3. FYB nonsense mutations in humans causing small-platelet thrombocytopenia and a significant bleeding tendency.

  4. Data (including data from studies in knockout/transgenic mice) suggest that ADAP regulates positive feedback loop of TGFbeta1 (zeige TGFB1 Antikörper) production and TGFbeta1 (zeige TGFB1 Antikörper)-induced CD103 (zeige ITGAE Antikörper) expression in CD8 (zeige CD8A Antikörper)+ T-lymphocytes and protects against influenza H5N1 virus infection.

  5. The aim of this study was to perform an association study between seven Fyn-binding protein gene (FYB)-tag single nucleotide polymorphisms (SNPs) and type I diabetes mellitus (T1DM), as well as with disease age of onset.

  6. The autosomal recessive bleeding phenotype seen in several members of this highly consanguineous family included petechial rash, mild epistaxis and thrombocytopenia with some decrease in platelet volume. These clinical findings, together with the results of exome sequencing pointed to only one strong candidate gene, the FYB gene.

  7. ADAP interacts with talin and kindlin-3 to promote platelet Integrin alphaIIbbeta3 activation and stable fibrinogen binding.

  8. ADAP and Nck (zeige NCK1 Antikörper) adapter proteins cooperatively facilitate T cell adhesion to the LFA-1 (zeige ITGAL Antikörper) ligand ICAM-1 (zeige ICAM1 Antikörper).

  9. These findings indicate that ADAP regulates two steps of HIV-1 infection cooperatively with two distinct receptors, and as such, serves as a new potential target in the blockade of HIV-1 infection.

  10. our findings indicate an association between polymorphisms located in FYB gene and SLE, suggesting their possible involvement in disease susceptibility and clinical manifestations.

Mouse (Murine) FYN-Binding Protein (FYB) Interaktionspartner

  1. ADAP (zeige APP Antikörper) fulfills different functions in CD4 (zeige CD4 Antikörper)(+) and CD8 (zeige CD8A Antikörper)(+) T cells, with CD8 (zeige CD8A Antikörper)(+) T cells being less dependent on ADAP (zeige APP Antikörper).

  2. ADAP (zeige APP Antikörper) regulates CD8 (zeige CD8A Antikörper) T cell differentiation events following acute pathogen challenge that are critical for the formation and selected functions of TRM cells in nonlymphoid tissues.

  3. Data (including data from studies in knockout/transgenic mice) suggest that ADAP (zeige APP Antikörper) regulates positive feedback loop of TGFbeta1 (zeige TGFB1 Antikörper) production and TGFbeta1 (zeige TGFB1 Antikörper)-induced CD103 (zeige ITGAE Antikörper) expression in CD8 (zeige CD8A Antikörper)+ T-lymphocytes and protects against influenza H5N1 virus infection.

  4. The results indicate that ADAP (zeige APP Antikörper) dampens naive CD8 (zeige CD8A Antikörper) T cell responses to lymphopenia and IL-15 (zeige IL15 Antikörper), and they demonstrate a novel Ag-independent function for ADAP (zeige APP Antikörper) in the suppression of memory phenotype CD8 (zeige CD8A Antikörper) T cell generation.

  5. provide evidence that CD28 (zeige CD28 Antikörper) and the TCR complex regulate NF-kappaB (zeige NFKB1 Antikörper) via different signaling modules of GRB-2 (zeige GRB2 Antikörper)/VAV1 (zeige VAV1 Antikörper) and LAT (zeige LAT Antikörper)/ADAP (zeige APP Antikörper) pathways respectively.

  6. ADAP interacts with talin and kindlin-3 to promote platelet Integrin alphaIIbbeta3 activation and stable fibrinogen binding.

  7. we demonstrate that loss of ADAP (zeige APP Antikörper) promotes resistance of experimental autoimmune encephalomyelitis in mice, likely by trapping encephalitogenic T cells in the peripheral lymph nodes on LYVE-1 (zeige LYVE1 Antikörper)+ lymphatic structures.

  8. Signaling by Fyn (zeige FYN Antikörper)-ADAP (zeige APP Antikörper) via the Carma1 (zeige CARD11 Antikörper)-Bcl-10 (zeige BCL10 Antikörper)-MAP3K7 (zeige MAP3K7 Antikörper) signalosome exclusively regulates inflammatory cytokine production in NK cells.

  9. integrin activation by the ADAP (zeige APP Antikörper)-SKAP55 (zeige SKAP1 Antikörper)-signaling module controls the stability and duration of T cell-dendritic cell contacts during the progressive phases necessary for optimal T cell activation.

  10. ADAP (zeige APP Antikörper) coordinates distinct CARMA1 (zeige CARD11 Antikörper)-dependent control of key cell cycle proteins in T cells

FYB Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T-cells. The encoded protein is involved in platelet activation and controls the expression of interleukin-2. Three transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with FYB

  • FYN-binding protein (fyb) Antikörper
  • FYN binding protein (FYB) Antikörper
  • FYN binding protein (Fyb) Antikörper
  • ADAP Antikörper
  • B630013F22Rik Antikörper
  • fyb Antikörper
  • FYB-120/130 Antikörper
  • p120/130 Antikörper
  • p120/p130 Antikörper
  • PRO0823 Antikörper
  • RGD1563421 Antikörper
  • SLAP-130 Antikörper
  • Slap130 Antikörper

Bezeichner auf Proteinebene für FYB

FYN-binding protein , FYB-120/130 , FYN-T-binding protein , SLP-76-associated phosphoprotein , adhesion and degranulation-promoting adaptor protein , p120/p130 , FYN binding protein FYB-130 , adhesion and degranulation promoting adaptor protein , FYN binding protein (FYB-120/130)

GENE ID SPEZIES
100195010 Salmo salar
2533 Homo sapiens
23880 Mus musculus
479355 Canis lupus familiaris
535347 Bos taurus
499537 Rattus norvegicus
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