anti-TIE1 (TIE1) Antikörper

Bezeichnung:
anti-tyrosine Kinase with Immunoglobulin-Like and EGF-Like Domains 1 Antikörper (TIE1)
Auf www.antikoerper-online.de finden Sie aktuell 229 tyrosine Kinase with Immunoglobulin-Like and EGF-Like Domains 1 (TIE1) Antikörper von 25 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen TIE1 Kits (32) und TIE1 Proteine (28) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 296 TIE1 Produkte verfügbar.
Synonyme:
D430008P04Rik, JTK14, TIE, tie-1

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anti-Human TIE1 Antikörper:

anti-Mouse (Murine) TIE1 Antikörper:

anti-Rat (Rattus) TIE1 Antikörper:

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Am meisten referenzierte anti-TIE1 Antikörper

  1. Human Polyclonal TIE1 Primary Antibody für FACS, IHC - ABIN4899695 : Danet, Pan, Luongo, Bonnet, Simon: Expansion of human SCID-repopulating cells under hypoxic conditions. in The Journal of clinical investigation 2003 (PubMed)
    Zeige alle 5 Referenzen für 4899695

  2. Human Polyclonal TIE1 Primary Antibody für EIA, IHC (p) - ABIN359947 : Verstovsek, Kantarjian, Manshouri, OBrien, Faderl, Talpaz, Cortes, Albitar: Prognostic significance of Tie-1 protein expression in patients with early chronic phase chronic myeloid leukemia. in Cancer 2002 (PubMed)
    Zeige alle 4 Referenzen für 359947

  3. Human Polyclonal TIE1 Primary Antibody für WB - ABIN955208 : Sato, Qin, Kozak, Audus: Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system. in Proceedings of the National Academy of Sciences of the United States of America 1993 (PubMed)
    Zeige alle 2 Referenzen für 955208

  4. Human Polyclonal TIE1 Primary Antibody für ICC, WB - ABIN871088 : Gu, Zhang, Wang, Mo, Zhou, Chen, Liu, Zhang: Global expression of cell surface proteins in embryonic stem cells. in PLoS ONE 2011 (PubMed)
    Zeige alle 2 Referenzen für 871088

  5. Human Monoclonal TIE1 Primary Antibody für ELISA, WB - ABIN449623 : Saulle, Guerriero, Petronelli, Coppotelli, Gabbianelli, Morsilli, Spinello, Pelosi, Castelli, Testa, Coppola: Autocrine role of angiopoietins during megakaryocytic differentiation. in PLoS ONE 2012 (PubMed)

Weitere Antikörper gegen TIE1 Interaktionspartner

Zebrafish tyrosine Kinase with Immunoglobulin-Like and EGF-Like Domains 1 (TIE1) Interaktionspartner

  1. Expression of a non-phosphorylatable mutant of the Tie1 juxtamembrane domain threonine site (T794A) significantly disrupted vascular development, resulting in fish with stunted and (zeige TEK Antikörper)poorly branched intersomitic vessels.

  2. Tie-1 and Tie-2 (zeige TEK Antikörper) are not required for early heart development, yet they have redundant roles for the maintenance of endocardial-myocardial connection in later stages.

  3. A natural antisense transcript was identified for tyrosine kinase containing immunoglobulin and epidermal growth factor (zeige EGF Antikörper) homology domain-1 (tie-1), tie-1AS long noncoding RNA in zebrafish, mouse, and humans.

Human tyrosine Kinase with Immunoglobulin-Like and EGF-Like Domains 1 (TIE1) Interaktionspartner

  1. Ang (zeige ANG Antikörper),Tie1 and Tie2 (zeige TEK Antikörper) play roles in vascular development and pathogenesis of vascular diseases.[review]

  2. In vitro binding assays with purified components reveal that Tie-integrin recognition is direct, and further demonstrate that the receptor binding domain of the Tie2 ligand (zeige ANGPT2 Antikörper) Ang-1 (zeige ANGPT1 Antikörper), but not the receptor binding domain of Ang-2 (zeige ANGPT2 Antikörper), can independently associate with a5b1 or aVb3. cooperative Tie/integrin interactions selectively stimulate ERK/MAPK (zeige MAPK1 Antikörper) signaling in the presence of both Ang-1 (zeige ANGPT1 Antikörper) and fibronectin (zeige FN1 Antikörper)

  3. The inhibition of Tie-2 (zeige TEK Antikörper) exerted by Tie-1can be relieved by Tie-1 ectodomain cleavage mediated by tumor- and inflammatory-related factors, which causes destabilization of vessels and initiates vessel remodeling in cancer. (Review)

  4. T794A-expressing human umbilical vein endothelial cells formed significantly shorter tubes with fewer branches in three-dimensional Matrigel cultures, but did not alter Tie1 or Tie2 (zeige TEK Antikörper) tyrosine phosphorylation or downstream signaling.

  5. The decreasing expression of Tie1 may play an important role in the pathogenesis of primary lower extremity varicose veins.

  6. Data propose that EndMT associated with Tie1 downregulation participates in the pathological development of stroma observed in tumours.

  7. the effects of factors activating ectodomain cleavage on both Tie1 and Tie2 (zeige TEK Antikörper) within the same population of cells, and their impact on angiopoietin signalling

  8. these results suggest that the expression level of Tie1 and its physical interaction with Tie2 (zeige TEK Antikörper) defines whether Ang2 (zeige ANGPT2 Antikörper) functions as a Tie2 (zeige TEK Antikörper) agonist or antagonist, thereby determining the context-dependent differential endothelial sensitivity to Ang2 (zeige ANGPT2 Antikörper).

  9. The Tie-1 immunoreactivity was dominantly observed in the heamangiogenic cells and cells cords, whereas the matured villi showed immunoreactivity only in other components.

  10. Provide evidence for Tie1-Tie2 (zeige TEK Antikörper) complex formation on the cell surface and identify molecular surface areas essential for recognition. The Tie1-Tie2 (zeige TEK Antikörper) interactions are dynamic, inhibitory, and differentially modulated by angiopoietin-1 (zeige ANGPT1 Antikörper) and -2.

Mouse (Murine) tyrosine Kinase with Immunoglobulin-Like and EGF-Like Domains 1 (TIE1) Interaktionspartner

  1. Data support an interactive model of Tie1 and Tie2 (zeige TEK Antikörper) function, in which dynamically regulated Tie1 versus Tie2 (zeige TEK Antikörper) expression determines the net positive or negative effect of Tie1 on Tie2 (zeige TEK Antikörper) signaling.

  2. Data indicate that receptor tyrosine kinase (zeige ERBB3 Antikörper) Tie1 deletion resulted in lack of lymphatic valves and collecting vessel defects.

  3. In contrast to the important role of Tie2 (zeige TEK Antikörper) in the regulation of blood vascular development, Tie1 is crucial in the process of lymphatic remodeling and maturation, which is independent of Tie2 (zeige TEK Antikörper).

  4. Tie1 regulates tumor angiogenesis, postnatal sprouting angiogenesis, and endothelial cell survival, which are controlled by VEGF (zeige VEGFA Antikörper), Angpt, and Notch (zeige NOTCH1 Antikörper) signals

  5. Shear stress conditions that modulate atherogenic events also regulate Tie1 expression. Therefore, Tie1 may play a novel proinflammatory role in atherosclerosis.

  6. Developing lymphatic vasculature is particularly sensitive to alterations in Tie1 expression in mice.

  7. Loss of Tie1 results in lymphatic vascular abnormalities that precede the blood vessel phenotype, suggesting that Tie1 is involved in lymphangiogenesis.

  8. A natural antisense transcript was identified for tyrosine kinase (zeige TYRO3 Antikörper) containing immunoglobulin and epidermal growth factor (zeige EGF Antikörper) homology domain-1 (tie-1), tie-1AS long noncoding RNA in zebrafish, mouse, and humans.

  9. In the lung, Tie1 expression increases prior to birth and rises in the newborn animal, a pattern not found in other organs.

  10. Blood vessel homeostasis and endothelial cell survival depend on proper signalling through angiopoietin receptors such as the receptor tyrosine kinases Tie-1 and Tie-2 (zeige TEK Antikörper). Tie-1 and Tie-2 (zeige TEK Antikörper) localized to motile cilia of the oviduct.

TIE1 Antigen-Profil

Beschreibung des Gens

This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Alternative names and synonyms associated with TIE1

  • tyrosine kinase with immunoglobulin-like and EGF-like domains 1 (TIE1) Antikörper
  • tyrosine kinase with immunoglobulin-like and EGF-like domains 1 (LOC100350418) Antikörper
  • tyrosine-protein kinase receptor Tie-1 (CpipJ_CPIJ018933) Antikörper
  • endothelium-specific receptor tyrosine kinase 1 (tie1) Antikörper
  • tyrosine kinase with immunoglobulin-like and EGF-like domains 1 (Tie1) Antikörper
  • D430008P04Rik Antikörper
  • JTK14 Antikörper
  • TIE Antikörper
  • tie-1 Antikörper

Bezeichner auf Proteinebene für TIE1

tyrosine-protein kinase receptor Tie-1 , tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1 , tyrosine kinase with immunoglobulin and epidermal growth factor homology domains , tyrosine kinase receptor 1

GENE ID SPEZIES
482535 Canis lupus familiaris
100350418 Oryctolagus cuniculus
6053379 Culex quinquefasciatus
30746 Danio rerio
7075 Homo sapiens
280941 Bos taurus
21846 Mus musculus
89806 Rattus norvegicus
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