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Combination of high serum levels of soluble AXL and BNP had greater predictive value for heart failure than BNP alone.
These results demonstrate that Gas6 (zeige GAS6 Proteine)/Axl axis confers aggressiveness in breast cancer.
a lower stability and greater dynamic nature of the Axl kinase domain
Silencing AXL or the inhibition of AXL kinase activity significantly inhibits tumor cell migration and invasion in colorectal cancer.
we identify PROS1 (zeige PROS1 Proteine) as a driver of Oral Squamous Cell Carcinoma tumor growth and a modulator of AXL expression
Studies indicate that aberrant AXL receptor tyrosine kinase (AXL) signaling and development of an epithelial-to-mesenchymal transition (EMT (zeige ITK Proteine)) phenotype underlie resistance of anaplastic lymphoma kinase (ALK F1174L)-driven neuroblastoma (zeige ARHGEF16 Proteine) (NB) cells to TAE684 and its derivatives.
Studied axl kinase as a negative regulator of an alveolar epithelial cell phenotype; results found that inhibition of Axl kinase could form epithelial adhesion structure and augment surfactant protein production via the MET of human lung multi-potent cells.
AXL is efficiently and sequentially cleaved by alpha- and gamma-secretases in various types of cancer cell lines. The AXL intracellular domain cleavage product translocates into the nucleus via a nuclear localization sequence that harbored a basic HRRKK motif.
a relationship between AXL and the cellular response to DNA damage whereby abrogation of AXL signaling leads to accumulation of the DNA-damage markers gammaH2AX (zeige H2AFX Proteine), 53BP1 (zeige TP53BP1 Proteine), and RAD51 (zeige RAD51 Proteine).
Small molecule and antibody inhibitors of AXL and MER (zeige MERTK Proteine) have recently been described, and some of these have already entered clinical trials. The optimal design of treatment strategies to maximize the clinical benefit of these AXL and MER (zeige MERTK Proteine) targeting agents are discussed in relation to the different cancer types and the types of resistance encountered.
Both Axl+/- and Axl-/- suckling mice supported the replication of Zika virus.
reciprocal activation of Axl and Mer (zeige ERH Proteine) receptor tyrosine kinases has a major impact on the outcome of renal inflammation.
Axl is critical for survival of T lymphocytes, especially during vascular remodeling in hypertension.
Axl, Mertk (zeige MERTK Proteine) and Tyro3 (zeige TYRO3 Proteine) receptors are not required for Zika virus entry and infection.
Axl plays an essential role in the regulation of NK cell development as well as natural killer effector function.
Matrix metalloproteases ADAM10 (zeige ADAM10 Proteine) and TACE (ADAM17 (zeige ADAM17 Proteine)) cleave AXL receptor tyrosine kinase (Axl) in lupus-prone leukocytes.
Gas6 (zeige GAS6 Proteine)/Axl and Akt (zeige AKT1 Proteine)/FoxO1a (zeige FOXO1 Proteine) were involved in protective effects of testosterone on VSMCs senescence and collagen synthesis.
Axl allows specific identification of airway macrophages, and that its expression is critical for macrophage functional compartmentalization in the airspaces or lung interstitium.
results establish TAM (zeige CCNA1 Proteine) receptors as both controllers of microglial physiology and potential targets for therapeutic intervention in central nervous system disease
These results suggest that TAM (zeige CCNA1 Proteine) receptors support NSCs survival, proliferation and differentiation by regulating expression of neurotrophins, especially the nerve growth factor.
activation of receptor tyrosine kinase (zeige RET Proteine) Axl inhibits the osteogenic differentiation of vascular pericytes.
The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, this protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation and can also mediate cell aggregation by homophilic binding. Alternatively spliced transcript variants encoding different isoforms have been identified.
, AXL transforming sequence/gene
, tyrosine-protein kinase receptor UFO
, adhesion-related kinase
, ufo oncogene homolog