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anti-Human FAK Antikörper:
anti-Mouse (Murine) FAK Antikörper:
anti-Rat (Rattus) FAK Antikörper:
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Chicken Monoclonal FAK Primary Antibody für BI, IP - ABIN967736
Clancy, Rediske, Tang, Nijher, Frenkel, Philips, Abramson: Outside-in signaling in the chondrocyte. Nitric oxide disrupts fibronectin-induced assembly of a subplasmalemmal actin/rho A/focal adhesion kinase signaling complex. in The Journal of clinical investigation 1997
Show all 7 Pubmed References
Chicken Monoclonal FAK Primary Antibody für BI, IP - ABIN967737
Kim, Feldman: Insulin-like growth factor I prevents mannitol-induced degradation of focal adhesion kinase and Akt. in The Journal of biological chemistry 2002
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Human Polyclonal FAK Primary Antibody für IHC - ABIN966125
Sanders, Basson: p130cas but not paxillin is essential for Caco-2 intestinal epithelial cell spreading and migration on collagen IV. in The Journal of biological chemistry 2005
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Human Polyclonal FAK Primary Antibody für WB - ABIN361988
Shi, Boettiger: A novel mode for integrin-mediated signaling: tethering is required for phosphorylation of FAK Y397. in Molecular biology of the cell 2003
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Human Monoclonal FAK Primary Antibody für WB - ABIN1882052
Whitney, Chan, Blake, Cosand, Neubauer, Aruffo, Kanner: Human T and B lymphocytes express a structurally conserved focal adhesion kinase, pp125FAK. in DNA and cell biology 1993
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Human Monoclonal FAK Primary Antibody für BI, WB - ABIN968644
Calalb, Zhang, Polte, Hanks: Focal adhesion kinase tyrosine-861 is a major site of phosphorylation by Src. in Biochemical and biophysical research communications 1997
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Human Monoclonal FAK Primary Antibody für BI, WB - ABIN968643
McLean, Fincham, Frame: v-Src induces tyrosine phosphorylation of focal adhesion kinase independently of tyrosine 397 and formation of a complex with Src. in The Journal of biological chemistry 2000
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Human Monoclonal FAK Primary Antibody für BI, WB - ABIN968664
Ruest, Roy, Shi, Mernaugh, Hanks: Phosphospecific antibodies reveal focal adhesion kinase activation loop phosphorylation in nascent and mature focal adhesions and requirement for the autophosphorylation site. in Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 2000
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Human Monoclonal FAK Primary Antibody für ICS - ABIN1177060
Schlaepfer, Mitra, Ilic: Control of motile and invasive cell phenotypes by focal adhesion kinase. in Biochimica et biophysica acta 2004
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elevated levels of bile acid increase the tumorigenic potential of pancreatic cancer cells by inducing FXR (zeige NR1H4 Antikörper)/FAK/c-Jun (zeige JUN Antikörper) axis to upregulate MUC4 (zeige MUC4 Antikörper) expression.
Osteoprotegerin (zeige TNFRSF11B Antikörper) facilitates pulmonary arterial hypertension pathogenesis by regulating pulmonary arterial smooth muscle cell proliferation via integrin alphavbeta3 (zeige ITGAV Antikörper)/FAK/AKT (zeige AKT1 Antikörper) signaling pathway.
the active phosphorylated form of Src (Src (zeige SRC Antikörper)(pY416) ) is co-expressed in Exo (zeige PHM Antikörper) with phosphorylated FAK (FAK(pY861) ), a known target site of Src (zeige SRC Antikörper), which enhances proliferation and migration.
our findings identified FAK as a common aberrant protein overexpression in various subtypes of osteosarcoma. pFAK-Y397 overexpression can be used as a prognostic biomarker predicting poor OS for patients with metastatic osteosarcoma, and the expression of pFAK-Y397 differentiated good and poor responders to neoadjuvant chemotherapy.
Data suggest that the cytoplasmic domain of Sdc2 (zeige SDC2 Antikörper) is involved in regulation of expression of MMP7 (zeige MMP7 Antikörper) in colon carcinoma/adenocarcinoma cells; induction of MMP7 (zeige MMP7 Antikörper) involves protein kinase C gamma (zeige PRKCG Antikörper)-mediated FAK/ERK (zeige EPHB2 Antikörper) signaling. (Sdc2 (zeige SDC2 Antikörper) = syndecan-2 (zeige SDC2 Antikörper); MMP7 (zeige MMP7 Antikörper) = matrix metalloproteinase-7 (zeige MMP7 Antikörper); FAK = focal adhesion kinase 1)
High FAK expression is associated with melanoma.
High FAK expression is associated with Tunneling nanotubes formation in squamous cell carcinoma.
sp(2) -Iminosugar alpha-glucosidase (zeige AGLU Antikörper) inhibitor 1 (zeige PPP1R1A Antikörper)-C-octyl-2-oxa-3-oxocastanospermine inhibits breast cancer cell migration via beta1-integrin, Stim1 (zeige STIM1 Antikörper), and FAK signaling pathways.
results suggest that Kctd20 impacts proliferation and invasion of non-small cell lung cancer through enhancing Fak and Akt (zeige AKT1 Antikörper) phosphorylation
mTORC1/2 inhibition promotes reorganization of integrin/focal adhesion kinase-mediated adhesomes, induction of IGFR/IR-dependent PI3K (zeige PIK3CA Antikörper) activation, and Akt (zeige AKT1 Antikörper) phosphorylation via an integrin/FAK/IGF1R (zeige IGF1R Antikörper)-dependent process, mediating tumor drug resistance.
evidence that despite the fact that FAK is in the active, open conformation at CAs (zeige CSE1L Antikörper), its kinase activity is dispensable for ciliogenesis and ciliary function revealing that FAK plays a scaffolding role in multiciliated cells.
FAK is required for external force-induced spindle reorientation, suggesting that FAK's involvement in this process stems from a role in the transduction of external forces to the cell cortex.
FAK is required for tension-dependent organization of collective cell movements in Xenopus mesendoderm.
work identifies new roles for the FERM domain in the regulation of the dynamics of FAK on its signaling complexes in vivo and in vitro and identifies epiboly as the earliest developmental process in which FAK plays a crucial role during development
These data suggest an important role for the FERM domain in the activation of FAK.
FAK phosphorylation at Y861 is essential for lamellipodial protrusion induced by BDNF (zeige BDNF Antikörper), while phosphorylation at Y925 controls the rate of point contact turnover.
Data imply that FAK plays an essential role in chamber outgrowth and looping morphogenesis.
FAK is required for proper topographic positioning of retinal axons along the anterior-posterior axis of the optic tectum in Xenopus and zebrafish, a guidance decision mediated in part by A-type ephrins.
RhoA (zeige RHOA Antikörper) and membrane fluidity mediates the spatially polarized Src (zeige SRC Antikörper)/FAK activation in response to shear stress.
XIAP (zeige XIAP Antikörper) plays an essential role in shear stress-stimulated FAK phosphorylation.
mitochondrial oxidants generated in response to endothelial strain trigger FAK phosphorylation through a signaling pathway that involves protein kinase C (zeige PKC Antikörper)
These results suggest that TGF-beta1 (zeige TGFB1 Antikörper)-induced monolayer permeability involves focal adhesion and cytoskeletal rearrangement through both FAK/Src (zeige SRC Antikörper)-dependent and -independent pathways.
Results suggest focal adhesion kinase is involved in thrombospondin-1 (zeige THBS1 Antikörper)-induced vascular smooth muscle cell migration.
In conclusion, our observations reveal that PRRSV triggers the activation of FAK-PI3K-AKT-Rac1 signaling pathway to facilitate its entry into cells.
Data suggest that focal adhesion kinase (FAK)-SMAD 2/3 mediate signal crosstalk between type II collagen and TGF-beta1 and regulate glycosaminoglycan secretion in chondrocytic cells.
FAK is essentially required in chondrocyte communication with type II collagen (zeige COL2A1 Antikörper) by regulating type II collagen (zeige COL2A1 Antikörper) expression and cell proliferation.
High FAK expression is associated with skin squamous cell carcinoma.
In cardiomyocytes exposed to biomechanical stimulation, FAK accumulates in the nucleus, binds to and upregulates the transcriptional activity of MEF2c (zeige MEF2C Antikörper) through an interaction with the FAK focal adhesion targeting (FAT) domain.
FAK-knockout mice were shorter and showed reduced bone volume. Disruptions of FAK function in osteoblasts reduced mRNA and protein expression of Runx2 (zeige RUNX2 Antikörper) Osterix (zeige SP7 Antikörper) and collagen-1.
The remodeling of the stromal matrix by CAFs has been shown to increase tumor rigidity to indirectly regulate FAK Y397 phosphorylation in tumor cells to promote their growth and invasion. Accordingly, the Hic-5(-/-);PyMT tumor cells exhibited a reduction in FAK Y397 phosphorylation. Isolated Hic-5(-/-);PyMT CAFs were defective in stress fiber organization and exhibited reduced contractility
Focal adhesion kinase (FAK) in platelets regulated their migration into the tumor microenvironment, and FAK-deficient platelets completely prevented the rebound tumor growth.
dynamic changes to the extracellular matrix after injury promote fibroblast activation and inhibition of epithelial cell apoptosis in response to TGF-beta (zeige TGFB1 Antikörper) through FAK activation.
Results suggest that interleukin-6 (IL-6 (zeige IL6 Antikörper)) increases VEGF-C (zeige VEGFC Antikörper) induction and lymphangiogenesis may involve, at least in part, Src (zeige SRC Antikörper)-FAK-STAT3 (zeige STAT3 Antikörper) cascade in lymphatic endothelial cells (LECs).
identify FAK as a novel negative regulator of Beclin1 (zeige BECN1 Antikörper)-mediated autophagy and indicate that this pathway can facilitate the promotion of compensatory hypertrophic growth
FAK is tightly associated with H3K9 methylation and negatively related to the growth of tumor-repopulating cells.
These data support a crucial role for miR (zeige MYLIP Antikörper)-27 in promoting chondrogenic differentiation in the pharyngeal arches through regulation of FAK.
findings highlight an essential role of Paxillin (zeige PXN Antikörper) and FAK in controlling cardiac contractility via the recruitment of Vinculin (zeige VCL Antikörper) to mechano-sensitive sites in cardiomyocytes.
Data indicate that focal adhesion kinase (FAK) activity may be a mediator of the integrin alpha5/Fn1 interaction during zebrafish lens fiber morphogenesis.
Focal adhesion kinase (FAK) mediates regulation of growth cone adhesion in the optic tectum of zebrafish.
presynaptic FAK signaling may be disrupted, causing abnormal synaptic growth and transmission in the NF1 (zeige NF1 Antikörper) genetic
Fak56 may play a subtle role in the negative regulation of integrin adhesion
Fak56D mutation causes severe disruption of the optic stalk structure. These phenotypes were completely rescued by Fak56D transgene expression in the SG cells but not in photoreceptor cells.
An intron loss of Dfak gene in species of the Drosophila melanogaster subgroup.
Together these findings suggest that modulation of Fak56 function is important for action potential propagation and Ca2 (zeige CA2 Antikörper)+-regulated neuromuscular transmission in vivo.
Data show that Fak56 is required to restrict larval neuromuscular junctions (NMJ)growth during NMJ development and mediates an extracellular signal through the integrin receptor.
This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only three of them have been determined.
, FAK-related non-kinase polypeptide
, PTK2 protein tyrosine kinase 2
, focal adhesion kinase 1
, focal adhesion kinase-related nonkinase
, protein phosphatase 1 regulatory subunit 71
, protein phosphatase 1, regulatory subunit 71
, focal adhesion kinase pp125FAK
, protein-tyrosine kinase 2
, focal adhesion kinase
, focal ashension kinase 1
, protein tyrosine kinase 2.1
, activated Cdc42 kinase-like
, tyrosine kinase
, focal adhesion kinase homolog