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Evidence for PPP2R4 as a haploinsufficient tumor suppressor gene, defining a high-penetrance genetic mechanism for PP2A inhibition in human cancer.
data indicate that PTPalpha (zeige PTPRA ELISA Kits) and FAK (zeige PTK2 ELISA Kits), which are enriched in FAs (zeige FAS ELISA Kits), interact with IP3R1 (zeige ITPR1 ELISA Kits) at adjacent ER sites to spatially sequester IL-1 (zeige IL1A ELISA Kits)-induced Ca(2 (zeige CA2 ELISA Kits)+) signalling
oocyte-specific deletion of Ppp2r1a (zeige PPP2R1A ELISA Kits) led to severe female subfertility without affecting follicle survival, growth, and ovulation.
A Pak1-PP2A-ERM signaling axis mediates F-actin rearrangement and degranulation in mast cells.
PP2A (Protein Phosphatase 2A(Twins)) counteracts Plk4 (zeige PLK4 ELISA Kits) autophosphorylation, thus stabilizing Plk4 (zeige PLK4 ELISA Kits) and promoting centriole duplication
PP2A-A alpha transcriptional regulation is mediated by multiple factors including AP-2alpha (zeige TFAP2A ELISA Kits), CREB (zeige CREB1 ELISA Kits), ETS-1 (zeige ETS1 ELISA Kits), and SP-1 (zeige SP1 ELISA Kits)
Data show that DSB promote PP2A to associate with Ku 70 and Ku 86.
protein phosphatase 2A overexpression in NIH 3T3 cells
T-cell receptor (TCR)-dependent tyrosine phosphorylation may be the mechanism by which the regulatory subunit of PP2A prevents the inhibitory function of CTLA-4 (zeige CTLA4 ELISA Kits), before TCR-CTLA-4 (zeige CTLA4 ELISA Kits) coligation.
PP-2A regulation of paxillin (zeige PXN ELISA Kits) phosphorylation may have a role in controlling tumor cell adherence and motility.
Isoliensinine suppresses NF-kappaB (zeige NFKB1 ELISA Kits) in hepatocellular carcinoma cells through impairing PP2A/I2PP2A (zeige SET ELISA Kits) interaction and stimulating PP2A-dependent p65 (zeige GORASP1 ELISA Kits) dephosphorylation at Ser536
BIR (zeige KCNJ11 ELISA Kits) domain of XIAP (zeige XIAP ELISA Kits) activated the protein phosphatase 2 (PP2A) activity by decreasing the phosphorylation of PP2A at Tyr307 in its catalytic subunit, PP2A-C. Such activated PP2A prevented the deviant phosphorylation and activation of MAPK (zeige MAPK1 ELISA Kits) kinases/MAPKs, their downstream effector c-Jun (zeige JUN ELISA Kits); and in turn inhibiting transcription of c-Jun (zeige JUN ELISA Kits)-regulated miR (zeige MLXIP ELISA Kits)-200a
T-type channel signaling is redirected towards the activation of the kinase Akt1 (zeige AKT1 ELISA Kits), leading to increased expression of the anti-apoptotic protein survivin (zeige BIRC5 ELISA Kits), and a decrease in the pro-apoptotic mediator FoxO3A (zeige FOXO3 ELISA Kits). Finally, in iPAH cells, Akt1 (zeige AKT1 ELISA Kits) is no longer able to regulate caspase 9 (zeige CASP9 ELISA Kits) activation, whereas T-type channel overexpression reverses PP2A defect in iPAH cells but reinforces the deleterious effects of Akt1 (zeige AKT1 ELISA Kits) activation
The present results indicate that rs959627 predicts PPP2R2 B mRNA prefrontal expression in two independent post-mortem datasets as well as lateral prefrontal activity during working memory in healthy subjects and suggest that genetic modulation of signal transduction mediated by PP2A affects complex biological phenotypes of relevance for cognitive behavior.
the present study suggested that PP2A has an important role in regulating mast cell beta2-adrenoceptors
The results of this study demonstrated that HBx of hepatitis B virus impairs interferon signaling via increased expression of SOCS3 and PP2A.
The current study describes a novel pathogenic mechanism of action for human polyomavirus 6 small tumor (sT) antigen which involves binding to protein phosphatase 2A (PP2A) via its WFG motif and zinc binding sites for activation of PP2A's downstream oncogenic pathways (MEK (zeige MAP2K1 ELISA Kits)/ERK (zeige EPHB2 ELISA Kits)/c-Jun (zeige JUN ELISA Kits)).
The aim of this review is to shed light on the role of four different phosphatases (PTEN, PP2A, CDC25 (zeige RASGRF1 ELISA Kits) and DUSP1 (zeige DUSP1 ELISA Kits)) in five different solid tumors (breast cancer, lung cancer, pancreatic cancer, prostate cancer and ovarian cancer), in order to better understand the most frequent and aggressive primary cancer of the central nervous system, glioblastoma.
Oncoprotein CIP2A is stabilized via interaction with tumor suppressor PP2A/B56
Such effect by miR (zeige MLXIP ELISA Kits)-429 was again abolished with AMPKalpha1 (zeige PRKAA1 ELISA Kits) silence or mutation. Together, we propose that PP2A-c silence by miR (zeige MLXIP ELISA Kits)-429 activates AMPK (zeige PRKAA1 ELISA Kits) and protects osteoblastic cells from Dex.
Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms.
PP2A subunit A isoform PR65-alpha
, PP2A subunit A isoform R1-alpha
, protein phosphatase PP2A
, serine/threonine protein phosphatase A subunit type 2A
, serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
, PP2A phosphatase activator
, PP2A subunit B' isoform PR53
, phosphotyrosyl phosphatase activator
, protein phosphatase 2A, regulatory subunit B' (PR 53)
, serine/threonine-protein phosphatase 2A activator
, serine/threonine-protein phosphatase 2A regulatory subunit B'
, PP2A, subunit B', PR53 isoform
, serine/threonine-protein phosphatase 2A regulatory subunit 4
, protein tyrosine phosphatase, receptor type, A