anti-Human PPM1D Antikörper für Enzyme Immunoassay

Recommended PPM1D Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D) Antikörper
  • AV338790
  • Wip1
  • PP2C-DELTA
  • WIP1
  • protein phosphatase 1D magnesium-dependent, delta isoform
  • protein phosphatase, Mg2+/Mn2+ dependent, 1D
  • Ppm1d
  • PPM1D
Epitop
C-Term
18
15
9
9
7
7
3
3
3
1
1
1
Reaktivität
Human
73
20
18
1
Wirt
Kaninchen
66
8
Klonalität
Polyklonal
Konjugat
Dieser PPM1D Antikörper ist unkonjugiert
5
5
4
4
4
4
1
1
1
1
1
1
1
1
1
1
1
Applikation
Enzyme Immunoassay (EIA), Western Blotting (WB)
54
32
13
9
4
4
3
1
1
1
Hersteller
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Bilder

Produktnummer ABIN360767
407,00 €
Zzgl. Versandkosten 20,00 € und MWSt
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN2729805 EIA Rabbit IgG Anmelden zum Anzeigen Polyclonal

anti-PPM1D Antikörper für Enzyme Immunoassay mit den meisten Publikationen

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Applikation / Reaktivität Human
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Enzyme Immunoassay (EIA) 2 Antikörper
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Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 13 Antikörper
Immunohistochemistry (IHC) 8 Antikörper
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Immunoprecipitation (IP) 4 Antikörper
Western Blotting (WB) 54 Antikörper

General

Antigen Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D) Antikörper
Epitop C-Term
(18), (15), (9), (9), (7), (7), (3), (3), (3), (1), (1), (1)
Reaktivität Human
(73), (20), (18), (1)
Wirt Kaninchen
(66), (8)
Klonalität
Polyklonal
Konjugat Dieser PPM1D Antikörper ist unkonjugiert
(5), (5), (4), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Enzyme Immunoassay (EIA), Western Blotting (WB)
(54), (32), (13), (9), (4), (4), (3), (1), (1), (1)
Pubmed 1 Publikation vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-PPM1D Antikörper

Target Details PPM1D Anwendungsinformationen Handhabung ProductDetails: References for anti-PPM1D antibody (ABIN360767) Bilder
Spezifität This antibody reacts to PPM1D.
Reinigung Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human PPM1D.
Isotyp Ig

Target Details PPM1D

Produktdetails anti-PPM1D Antikörper Anwendungsinformationen Handhabung ProductDetails: References for anti-PPM1D antibody (ABIN360767) Bilder zurück nach oben
Antigen
Andere Bezeichnung Protein Phosphatase 1D / PPM1D (PPM1D Antibody Abstract)
Hintergrund PPM1D is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. Expression of this PPM1D gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negativelyregulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stressinduced apoptosis. The PPM1D gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.Synonyms: PP2C-delta, Protein phosphatase 2C isoform delta, Protein phosphatase magnesium-dependent 1 delta, WIP1, p53-induced protein phosphatase 1
Gen-ID 8493, 9606
UniProt O15297
Pathways p53 Signalweg, Zellzyklus

Anwendungsinformationen

Produktdetails anti-PPM1D Antikörper Target Details PPM1D Handhabung ProductDetails: References for anti-PPM1D antibody (ABIN360767) Bilder zurück nach oben
Applikationshinweise ELISA: 1/1,000. Western blotting: 1/100 - 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-PPM1D Antikörper Target Details PPM1D Anwendungsinformationen ProductDetails: References for anti-PPM1D antibody (ABIN360767) Bilder zurück nach oben
Format Liquid
Konzentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

ProductDetails: References for anti-PPM1D antibody (ABIN360767)

Produktdetails anti-PPM1D Antikörper Target Details PPM1D Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Han, Yu, Song, Park, Jang, Choi: "The estrogen receptor alpha pathway induces oncogenic Wip1 phosphatase gene expression." in: Molecular cancer research : MCR, Vol. 7, Issue 5, pp. 713-23, 2009

Bilder

Produktdetails anti-PPM1D Antikörper Target Details PPM1D Anwendungsinformationen Handhabung ProductDetails: References for anti-PPM1D antibody (ABIN360767) zurück nach oben
Bilder des Herstellers
 image for anti-PPM1D Antikörper (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D) (C-Term) (ABIN360767) anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D) (C-Term) antibody