anti-Maus p53 Antikörper für Immunofluorescence (Paraffin-embedded Sections)

Recommended p53 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Tumor Protein P53 (TP53) Antikörper
  • tp53
  • p53
  • TP53
  • Tp53
  • bbl
  • bfy
  • bhy
  • p44
  • TpMs
  • BCC7
  • LFS1
  • P53
  • TRP53
  • Trp53
  • Xp53
  • brp53
  • drp53
  • etID22686.5
  • fb40d06
  • wu:fb40d06
  • zgc:111919
  • cellular tumor antigen p53
  • tumor protein p53
  • tumor supressor p53
  • p53 tumor suppressor
  • transformation related protein 53
  • transformation related protein 53, pseudogene
  • trichoplein, keratin filament binding
  • Wistar clone pR53P1 p53 pseudogene
  • CpipJ_CPIJ002758
  • TP53
  • tp53
  • P53
  • Trp53
  • Trp53-ps
  • TCHP
  • Tp53
  • p53-ps
Epitop
AA 240-290, Wild Type
173
128
94
84
74
71
70
62
59
55
50
49
48
47
42
38
32
31
29
28
24
22
20
20
16
16
15
15
15
15
14
14
12
11
10
10
10
9
9
8
7
7
7
7
7
7
6
6
6
6
6
5
5
5
5
5
5
5
5
5
5
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
2428
518
425
188
127
94
87
84
35
23
20
18
17
16
15
14
6
4
4
4
4
3
3
3
2
2
1
1
Wirt
Kaninchen
1371
1170
7
3
1
1
1
1
Klonalität
Polyklonal
Konjugat
Dieser p53 Antikörper ist unkonjugiert
81
78
65
55
49
48
34
34
26
26
25
25
25
25
25
24
24
24
23
22
22
21
14
14
14
14
14
12
7
5
5
5
5
5
5
5
5
4
3
2
2
2
Applikation
Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
1931
772
751
741
651
637
435
347
316
178
72
41
32
31
24
17
17
15
12
9
9
4
4
3
3
3
2
2
1
1
1
1
1
1
1
1
1
1
Optionen
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Bilder

Produktnummer ABIN723935
$ 307.45
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN677408 IF (p) IHC (p) WB Rabbit IgG AA 345-390, Wild Type Anmelden zum Anzeigen Polyclonal 1
1 ABIN1386190 IF (p) IHC (p) WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 1
1 ABIN702895 IF (p) IHC (p) WB Rabbit IgG AA 5-55, pSer20 Anmelden zum Anzeigen Polyclonal
1 ABIN2804970 IF (p) Alexa Fluor 594 Rabbit IgG AA 5-55, pSer20 Anmelden zum Anzeigen Polyclonal
1 ABIN702901 IF (p) Cy7 Rabbit IgG AA 5-55, pSer20 Anmelden zum Anzeigen Polyclonal
1 ABIN874746 IF (p) Alexa Fluor 350 Rabbit IgG AA 5-55, pSer20 Anmelden zum Anzeigen Polyclonal
1 ABIN874747 IF (p) Alexa Fluor 488 Rabbit IgG AA 5-55, pSer20 Anmelden zum Anzeigen Polyclonal
1 ABIN874750 IF (p) Alexa Fluor 555 Rabbit IgG AA 5-55, pSer20 Anmelden zum Anzeigen Polyclonal
1 ABIN874748 IF (p) Alexa Fluor 647 Rabbit IgG AA 5-55, pSer20 Anmelden zum Anzeigen Polyclonal
1 ABIN702898 IF (p) Cy3 Rabbit IgG AA 5-55, pSer20 Anmelden zum Anzeigen Polyclonal
1 ABIN702900 IF (p) Cy5.5 Rabbit IgG AA 5-55, pSer20 Anmelden zum Anzeigen Polyclonal
1 ABIN702902 IF (p) FITC Rabbit IgG AA 5-55, pSer20 Anmelden zum Anzeigen Polyclonal
1 ABIN702899 IF (p) Cy5 Rabbit IgG AA 5-55, pSer20 Anmelden zum Anzeigen Polyclonal
1 ABIN2804978 IF (p) Alexa Fluor 594 Rabbit IgG pThr81 Anmelden zum Anzeigen Polyclonal
1 ABIN2804977 IF (p) Alexa Fluor 594 Rabbit IgG pThr18 Anmelden zum Anzeigen Polyclonal
1 ABIN2804980 IF (p) Alexa Fluor 594 Rabbit IgG pSer376 Anmelden zum Anzeigen Polyclonal
1 ABIN723942 IF (cc) IF (p) FITC Rabbit IgG AA 240-290, Wild Type Anmelden zum Anzeigen Polyclonal
1 ABIN723938 IF (cc) IF (p) Cy3 Rabbit IgG AA 240-290, Wild Type Anmelden zum Anzeigen Polyclonal
1 ABIN723939 IF (cc) IF (p) Cy5 Rabbit IgG AA 240-290, Wild Type Anmelden zum Anzeigen Polyclonal
1 ABIN723940 IF (cc) IF (p) Cy5.5 Rabbit IgG AA 240-290, Wild Type Anmelden zum Anzeigen Polyclonal

General

Antigen Tumor Protein P53 (TP53) Antikörper
Epitop AA 240-290, Wild Type
(173), (128), (94), (84), (74), (71), (70), (62), (59), (55), (50), (49), (48), (47), (42), (38), (32), (31), (29), (28), (24), (22), (20), (20), (16), (16), (15), (15), (15), (15), (14), (14), (12), (11), (10), (10), (10), (9), (9), (8), (7), (7), (7), (7), (7), (7), (6), (6), (6), (6), (6), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reaktivität Human, Maus, Ratte (Rattus)
(2428), (518), (425), (188), (127), (94), (87), (84), (35), (23), (20), (18), (17), (16), (15), (14), (6), (4), (4), (4), (4), (3), (3), (3), (2), (2), (1), (1)
Wirt Kaninchen
(1371), (1170), (7), (3), (1), (1), (1), (1)
Klonalität
Polyklonal
Konjugat Dieser p53 Antikörper ist unkonjugiert
(81), (78), (65), (55), (49), (48), (34), (34), (26), (26), (25), (25), (25), (25), (25), (24), (24), (24), (23), (22), (22), (21), (14), (14), (14), (14), (14), (12), (7), (5), (5), (5), (5), (5), (5), (5), (5), (4), (3), (2), (2), (2)
Applikation Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(1931), (772), (751), (741), (651), (637), (435), (347), (316), (178), (72), (41), (32), (31), (24), (17), (17), (15), (12), (9), (9), (4), (4), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Pubmed 4 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-p53 Antikörper

Target Details p53 Anwendungsinformationen Handhabung Referenzen für anti-p53 Antikörper (ABIN723935) Bilder
Reinigung Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human P53
Isotyp IgG

Target Details p53

Produktdetails anti-p53 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-p53 Antikörper (ABIN723935) Bilder zurück nach oben
Antigen
Andere Bezeichnung P53 Protein (TP53 Antibody Abstract)
Hintergrund

Acts as a tumor suppressor in many tumor types, induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis, the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.

Subcellular location: Cytoplasm, Nucleus

Synonyms: P53, BCC7, LFS1, TRP53, Cellular tumor antigen p53, Antigen NY-CO-13, Phosphoprotein p53, Tumor suppressor p53, TP53

Gen-ID 7157
UniProt P04637
Pathways p53 Signalweg, MAPK Signalweg, PI3K-Akt Signalweg, Apoptose, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagie

Anwendungsinformationen

Produktdetails anti-p53 Antikörper Target Details p53 Handhabung Referenzen für anti-p53 Antikörper (ABIN723935) Bilder zurück nach oben
Applikationshinweise WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-p53 Antikörper Target Details p53 Anwendungsinformationen Referenzen für anti-p53 Antikörper (ABIN723935) Bilder zurück nach oben
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C
Haltbarkeit 12 months

Referenzen für anti-p53 Antikörper (ABIN723935)

Produktdetails anti-p53 Antikörper Target Details p53 Anwendungsinformationen Handhabung Bilder zurück nach oben
Produkt verwendet in:

Wang, Liu, Liu, Chen, Liu, Kuang: "Hypoxia Inhibits Myogenic Differentiation through p53 Protein-dependent Induction of Bhlhe40 Protein." in: The Journal of biological chemistry, Vol. 290, Issue 50, pp. 29707-16, 2015

Hong, Shen, Liu, Li, Huang, Shi: "Developmental toxicity of three hexabromocyclododecane diastereoisomers in embryos of the marine medaka Oryzias melastigma." in: Marine pollution bulletin, Vol. 101, Issue 1, pp. 110-8, 2015

Chen, Shi, Liu, Fang, Zhang, Zhao: "Targeting SPARC by lentivirus-mediated RNA interference inhibits cervical cancer cell growth and metastasis." in: BMC cancer, Vol. 12, pp. 464, 2012 (1:1000).

Carry, Banssillon: "[Intra-abdominal pressure]." in: Annales francaises d'anesthesie et de reanimation, Vol. 13, Issue 3, pp. 381-99, 1995 Von den Autoren verwendete Methode: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Probematerial (Species): Rat (Rattus)).

Bilder

Produktdetails anti-p53 Antikörper Target Details p53 Anwendungsinformationen Handhabung Referenzen für anti-p53 Antikörper (ABIN723935) zurück nach oben
Bilder des Herstellers
Immunohistochemistry (IHC) image for anti-Tumor Protein P53 (TP53) (AA 240-290), (Wild Type) antibody (ABIN723935) Formalin-fixed and paraffin embedded human ovarian carcinoma labeled with Rabbit Anti...
SDS-PAGE (SDS) image for anti-Tumor Protein P53 (TP53) (AA 240-290), (Wild Type) antibody (ABIN723935) 1 rat brain, L2 human colon carcinoma lysates probed (ABIN723935) at 1:200 in 4 °C. F...
Immunofluorescence (IF) image for anti-Tumor Protein P53 (TP53) (AA 240-290), (Wild Type) antibody (ABIN723935) Image kindly submitted by Piotr Mamczur from Wroclaw University. Immunofluorescent lo...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Tumor Protein P53 (TP53) (AA 240-290), (Wild Type) antibody (ABIN723935) Formalin-fixed and paraffin embedded human ovarian carcinoma labeled with Rabbit Anti...