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Human MDM2 Protein expressed in Wheat germ - ABIN1310600
Zhang, Zhong, Chen: LC-MS/MS-based targeted proteomics quantitatively detects the interaction between p53 and MDM2 in breast cancer. in Journal of proteomics 2016
High MDM2 expression is associated with acute myeloid leukemia (zeige BCL11A Proteine).
mutant Mdm2 was unable to rescue a p53 (zeige TP53 Proteine)-induced apoptotic phenotype.
High MDM2 expression is associated with Sjogren's syndrome.
MDM2 expression was an independent and unfavorable prognostic factor of overall survival. Additionally, MDM2 expression was significantly associated with progressive disease and death
These results suggested that variants MDM2 SNP309 and p53 (zeige TP53 Proteine) Arg72Pro are susceptibility factors for hepatocellular carcinoma
MDM2 SNP285-SNP309 polymorphisms association with genetic predisposition to cancer in Li-Fraumeni syndrome (zeige TP53 Proteine) Italian patients.
a novel molecular mechanism which, in silico, is capable of triggering p53 (zeige TP53 Proteine) oscillations. The mechanism that is based on Mdm2's dual regulation of p53 (zeige TP53 Proteine) can provide mechanistic insights into an excitability of the p53 (zeige TP53 Proteine) network, thus it contributes to understanding of variability of p53 (zeige TP53 Proteine) dynamics in response to single and double strand breaks.
Histologically low-grade and relatively low-grade cases of extraskeletal osteosarcoma are not always associated with MDM2 amplification. ESOS cases with MDM2 amplification could be high grade.
Disturbed p53 (zeige TP53 Proteine)-MDM2 feedback loop contributing to the pathogenesis of thoracic aortic dissection may be linked to TRIM25 (zeige TRIM25 Proteine) overexpression.
These results identify a novel function for FKBP12 in downregulating MDM2, which directly enhances sensitivity of cancer cells to chemotherapy and nutlin-3 treatment.
results suggest overexpression of MDM2 is closely linked to inhibition of p53 (zeige TP53 Proteine)-dependent apoptosis of Theileria parva (zeige PARVA Proteine)-infected lymphocytes; aberrant expression of host lymphocyte MDM2 induced by cytoplasmic existence of T. parva (zeige PARVA Proteine), directly and/or indirectly, is associated with aspects of this type of transformation of T. parva (zeige PARVA Proteine)-infected lymphocytes
Data indicate that knockdown of the Mdm2 and Mdm4 (zeige MDM4 Proteine) caused dramatic accumulation of mutant p53 protein (zeige TP53 Proteine).
Together with p53 (zeige TP53 Proteine), provides an experimental model for characterizing drugs and genes that affect p53 (zeige TP53 Proteine) signaling.
Data show that liver-specific expression of p53 (zeige TP53 Proteine)-negative regulator mdm2 leads to growth retardation and fragile liver in zebrafish.
the existence of an unusual functional interplay between STATs and CREB (zeige CREB1 Proteine) at the onset of adipogenesis through shared CRTC cofactors, is reported.
Mdm2 expression is required for cell survival even in the absence of p53 (zeige TP53 Proteine). Moreover, results suggest that p73 (zeige ARHGAP24 Proteine) compensates for loss of p53 (zeige TP53 Proteine).
In Fmr1 (zeige FMR1 Proteine) KO neurons, Mdm2 is hyperphosphorylated, nuclear localized basally, and unaffected by MEF2 (zeige MEF2C Proteine) activation, which our data suggest due to an enhanced interaction with Eukaryotic Elongation Factor (zeige TSFM Proteine) 1alpha (EF1alpha), whose protein levels are elevated in Fmr1 (zeige FMR1 Proteine) KO. Expression of a dephosphomimetic of Mdm2 rescues PSD-95 (zeige DLG4 Proteine) ubiquitination, degradation and synapse elimination in Fmr1 (zeige FMR1 Proteine) KO neurons.
MDM2 is a non-redundant survival factor for proximal tubular cells by protecting them from spontaneous p53 (zeige TP53 Proteine) overexpression-related cell death.
The case emphasizes that MDM2 expression represents a possible pitfall in the diagnosis of spindle cell tumors. The differential diagnostic distinction between FDCS and a dedifferentiated liposarcoma is discussed.
MDM2 is involved in fibroblast activation, mediating renal tubulointerstitial fibrosis via a p53 (zeige TP53 Proteine)-independent pathway dependant on Notch1 (zeige NOTCH1 Proteine) ubiquitination and proteasome degradation.
These findings suggest that Mdm2 splice isoforms may play critical roles in the regulatory loop of p53 (zeige TP53 Proteine)/Mdm2-Mdm4 (zeige MDM4 Proteine) via a RING domain-mediated biochemical mechanism.
both MDM2 and MDMX (zeige MDM4 Proteine) deletion-caused pancreatic defects are completely rescued by loss of p53 (zeige TP53 Proteine), verifying the crucial role of the MDM2 and/or MDMX (zeige MDM4 Proteine) in regulating p53 (zeige TP53 Proteine) in a spatio-temporal manner during the development, functional maintenance, and related disease progress of endocrine pancreas.
Vif (zeige BTG1 Proteine) stabilization by CBFbeta (zeige CBFB Proteine) is mainly caused by impairing MDM2-mediated degradation.
These results demonstrated a critical prosurvival role for MDM2 in the oocytes
This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues.
E3 ubiquitin-protein ligase Mdm2
, Mdm2, p53 E3 ubiquitin protein ligase homolog
, Mdm2, transformed 3T3 cell double minute 2, p53 binding protein
, double minute 2, human homolog of; p53-binding protein
, oncoprotein Mdm2
, Mdm2 p53 binding protein homolog
, double minute 2 protein
, p53-binding protein Mdm2
, MDM2 alpha
, double minute 2 homolog
, double minute 2
, MDM2-like protein
, transformed mouse 3T3 cell double minute 2
, murine double minute 2 homolog