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Human MDM2 Protein expressed in Wheat germ - ABIN1310600
Zhang, Zhong, Chen: LC-MS/MS-based targeted proteomics quantitatively detects the interaction between p53 and MDM2 in breast cancer. in Journal of proteomics 2016
Data suggest that Per2 (zeige PER2 Proteine) is not only a tumor suppressor gene but can also be regarded as a regulator of MDM2-TP53 (zeige TP53 Proteine) pathway.
Simulation of HEY1 (zeige HEY1 Proteine) Ser (zeige SIGLEC1 Proteine)-68 phosphorylation prevents its interaction with p53 (zeige TP53 Proteine), RPL11 (zeige RPL11 Proteine) and MDM2 and abolishes HEY1 (zeige HEY1 Proteine) migration to nucleolar caps (zeige CAPS Proteine) upon ribosomal stress. Our findings uncover a novel mechanism for cross-talk between Notch (zeige NOTCH1 Proteine) signalling and nucleolar stress
we have herein demonstrated that ERalpha (zeige ESR1 Proteine) expression associates with MDM4 (zeige MDM4 Proteine) and MDM2 gene expression in primary breast invasive carcinoma samples
overview of apoptosis and cell-cycle arrest in human cancer, highlighting the frequent occurrence of MDM2 amplification in sarcoma and the role of SNP309 and SNP285 in regulating MDM2 expression and cancer risk [review]
quantitative detection of p53 (zeige TP53 Proteine)-MDM2 interaction in breast cells and tissue samples.
It is now clear that functional p53 (zeige TP53 Proteine) is critical to protect the genome from alterations that lead to tumorigenesis. The current understanding of the multiple ways p53 (zeige TP53 Proteine) contributes to genome stability and how two of its negative regulators, Mdm2 and Mdmx (zeige MDM4 Proteine), induce genome instability will be described. [review]
simultaneous mutations at all four acetylation sites completely abolish its ability to regulate metabolic targets, such as TIGAR (zeige C12orf5 Proteine) and SLC7A11. Moreover, p53 (zeige TP53 Proteine)(4KR) is still capable of inducing the p53 (zeige TP53 Proteine)-Mdm2 feedback loop, but p53 (zeige TP53 Proteine)-dependent ferroptotic responses are markedly abrogated
Data indicate that acetyltransferase p300 (zeige EP300 Proteine) acetylates oncogenic E3 ubiquitin ligase (zeige MUL1 Proteine) murine double minute 2 (MDM2) at Lys182 and Lys185.
High amplification levels of MDM2 is associated with dedifferentiated liposarcoma.
Herein is shown that tumor cells with MDM2 amplification are selectively resistant to treatment with topoisomerase II (zeige TOP2 Proteine) poisons but not other DNA damaging agents.Herein is shown that tumor cells with MDM2 amplification are selectively resistant to treatment with topoisomerase II (zeige TOP2 Proteine) poisons but not other DNA damaging agents
results suggest overexpression of MDM2 is closely linked to inhibition of p53 (zeige TP53 Proteine)-dependent apoptosis of Theileria parva (zeige PARVA Proteine)-infected lymphocytes; aberrant expression of host lymphocyte MDM2 induced by cytoplasmic existence of T. parva (zeige PARVA Proteine), directly and/or indirectly, is associated with aspects of this type of transformation of T. parva (zeige PARVA Proteine)-infected lymphocytes
mutant Mdm2 was unable to rescue a p53 (zeige TP53 Proteine)-induced apoptotic phenotype.
Data indicate that knockdown of the Mdm2 and Mdm4 (zeige MDM4 Proteine) caused dramatic accumulation of mutant p53 protein (zeige TP53 Proteine).
Together with p53 (zeige TP53 Proteine), provides an experimental model for characterizing drugs and genes that affect p53 (zeige TP53 Proteine) signaling.
Data show that liver-specific expression of p53 (zeige TP53 Proteine)-negative regulator mdm2 leads to growth retardation and fragile liver in zebrafish.
The availability of large-scale genomic profiling datasets, like those from The Cancer Genome Atlas Research Network, have provided the opportunity to evaluate the consequences of MDM2 amplification and SNP inheritance across high-quality tumor samples from diverse cancer indications. [review]
findings document contrasting effects of ATM (zeige ATM Proteine)-Mdm2 signaling on p53 (zeige TP53 Proteine) tumor suppression and reveal that destabilizing Mdm2 by promoting its phosphorylation by ATM (zeige ATM Proteine) would be effective in treating oncogene (zeige RAB1A Proteine)-induced malignancies.
the existence of an unusual functional interplay between STATs and CREB (zeige CREB1 Proteine) at the onset of adipogenesis through shared CRTC cofactors, is reported.
Mdm2 expression is required for cell survival even in the absence of p53 (zeige TP53 Proteine). Moreover, results suggest that p73 (zeige ARHGAP24 Proteine) compensates for loss of p53 (zeige TP53 Proteine).
In Fmr1 (zeige FMR1 Proteine) KO neurons, Mdm2 is hyperphosphorylated, nuclear localized basally, and unaffected by MEF2 (zeige MEF2C Proteine) activation, which our data suggest due to an enhanced interaction with Eukaryotic Elongation Factor (zeige TSFM Proteine) 1alpha (EF1alpha), whose protein levels are elevated in Fmr1 (zeige FMR1 Proteine) KO. Expression of a dephosphomimetic of Mdm2 rescues PSD-95 (zeige DLG4 Proteine) ubiquitination, degradation and synapse elimination in Fmr1 (zeige FMR1 Proteine) KO neurons.
MDM2 is a non-redundant survival factor for proximal tubular cells by protecting them from spontaneous p53 (zeige TP53 Proteine) overexpression-related cell death.
The case emphasizes that MDM2 expression represents a possible pitfall in the diagnosis of spindle cell tumors. The differential diagnostic distinction between FDCS and a dedifferentiated liposarcoma is discussed.
MDM2 is involved in fibroblast activation, mediating renal tubulointerstitial fibrosis via a p53 (zeige TP53 Proteine)-independent pathway dependant on Notch1 (zeige NOTCH1 Proteine) ubiquitination and proteasome degradation.
These findings suggest that Mdm2 splice isoforms may play critical roles in the regulatory loop of p53 (zeige TP53 Proteine)/Mdm2-Mdm4 (zeige MDM4 Proteine) via a RING domain-mediated biochemical mechanism.
both MDM2 and MDMX (zeige MDM4 Proteine) deletion-caused pancreatic defects are completely rescued by loss of p53 (zeige TP53 Proteine), verifying the crucial role of the MDM2 and/or MDMX (zeige MDM4 Proteine) in regulating p53 (zeige TP53 Proteine) in a spatio-temporal manner during the development, functional maintenance, and related disease progress of endocrine pancreas.
This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues.
E3 ubiquitin-protein ligase Mdm2
, Mdm2, p53 E3 ubiquitin protein ligase homolog
, Mdm2, transformed 3T3 cell double minute 2, p53 binding protein
, double minute 2, human homolog of; p53-binding protein
, oncoprotein Mdm2
, Mdm2 p53 binding protein homolog
, double minute 2 protein
, p53-binding protein Mdm2
, MDM2 alpha
, double minute 2 homolog
, double minute 2
, MDM2-like protein
, transformed mouse 3T3 cell double minute 2
, murine double minute 2 homolog