Checkpoint Kinase 2 ELISA Kits (CHEK2)
Auf finden Sie aktuell 15 Checkpoint Kinase 2 (CHEK2) ELISA Kits von 5 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen CHEK2 Antikörper (482) und CHEK2 Proteine (13) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 533 CHEK2 Produkte verfügbar.
Cds1, CHK-2, Chk2, fa66f08, hCds1, HUCDS1, LFS2, PP1425, Rad53, wu:fa66f08, zgc:55865

CHEK2 (CHEK2) ELISA Kits nach Reaktivitäten

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Weitere ELISA Kits für CHEK2 Interaktionspartner

Human Checkpoint Kinase 2 (CHEK2) Interaktionspartner

  1. In this paper, we describe an extension to the BOADICEA model to incorporate the effects of intermediate risk variants for breast cancer, specifically loss of function mutations in the three genes for which the evidence for association is clearest and the risk estimates most precise: PALB2 (zeige PALB2 ELISA Kits), CHEK2 and ATM (zeige ATM ELISA Kits)

  2. SIAH2 (zeige SIAH2 ELISA Kits) regulates CHK2 basal turnover, with important consequences on cell-cycle control and on the ability of hypoxia to alter the DNA damage-response pathway in cancer cells.

  3. MCM2 (zeige MCM2 ELISA Kits)-MCM6 (zeige MCM6 ELISA Kits) complex is required for CHK2 chromatin loading and its phosphorylation to DNA damage response in squamous cell carcinoma cells.

  4. On the basis of analyses of approximately 87,000 controls and patients with breast cancer from population- and hospital-based studies, our best estimate for the relative risk of invasive breast cancer for carriers of the 1100delC mutation in CHEK2, compared with noncarriers, was 2.26 (95% CI, 1.90 to 2.69).

  5. the G2 damage checkpoint prevents stable recruitment of the chromosome-packaging-machinery components condensin complex (zeige SMC4 ELISA Kits) I and II onto the chromatin even in the presence of an active Cdk1 (zeige CDK1 ELISA Kits).

  6. data suggest that cancer risks reported for founder mutations may be generalizable to all CHEK2 + s, particularly for breast cancer

  7. K373E mutation of CHK2 in tumorigenesis

  8. Checkpoint kinase 1 (zeige CHEK1 ELISA Kits) and 2 signaling is important for apoptin regulation.

  9. High CHEK2 expression is associated with Lung Adenocarcinoma.

  10. Our study reports the first case of Li-Fraumeni syndrome (zeige TP53 ELISA Kits)-like in Chinese patients and demonstrates the important contribution of de novo mutations in this type of rare disease.

Mouse (Murine) Checkpoint Kinase 2 (CHEK2) Interaktionspartner

  1. work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF (zeige TRAF1 ELISA Kits)/NF-kappaB (zeige NFKB1 ELISA Kits)-regulated apoptosis and the p53 (zeige TP53 ELISA Kits)/PCNA (zeige PCNA ELISA Kits)- and ATM (zeige ATM ELISA Kits)/ATR (zeige ATR ELISA Kits)-Chk1 (zeige CHEK1 ELISA Kits)/2-controlled DNA-damage response pathways.

  2. Together, this study described the regulation of Chk2 expression through promoter methylation by Dnmt3b (zeige DNMT3B ELISA Kits) and also presented a novel role of Chk2 during neuronal differentiation, which is independent of its previously known function in DNA damage response.

  3. We conclude that Chk2 regulates renal 25-hydroxyvitamin D 1alpha-hydroxylase expression thereby impacting on calcium and phosphate metabolism.

  4. TRIP13 (zeige TRIP13 ELISA Kits)-deficient spermatocytes also progress to an H1t (zeige HIST1H1T ELISA Kits)-positive stage if ATM (zeige ATM ELISA Kits) activity is attenuated by hypomorphic mutations in Mre11 (zeige MRE11A ELISA Kits) or Nbs1 (zeige NBN ELISA Kits) or by elimination of the ATM (zeige ATM ELISA Kits)-effector kinase CHK2

  5. Results represent the first demonstration of a role for CHK2 in the in vivo signaling of dysfunctional telomeres.

  6. DNA-PK/Chk2 signaling induces centrosome amplification upon long-term HU treatment, therefore increasing our insight into tumor recurrence after initial chemotherapy.

  7. Results demonstrate that Chk2 plays important roles in regulating cell cycle progression during female meiosis and early embryo development.

  8. These data establish CHK2 as essential for DNA damage surveillance in female meiosis and indicate that the oocyte DNA double-strand breaks damage response primarily involves a pathway hierarchy in which ataxia telangiectasia and Rad3-related (ATR) signals to CHK2, which then activates p53 and p63.

  9. Findings indicate that PIRH2 (zeige RCHY1 ELISA Kits) has central roles in the ubiquitylation of Chk2 and its turnover and in the regulation of its function.

  10. Chk2 deficiency in Myc (zeige MYC ELISA Kits) overexpressing lymphoma cells elicits a synergistic lethal response in combination with PARP (zeige PARP1 ELISA Kits) inhibition.

CHEK2 Antigen-Profil

Beschreibung des Gens

In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with CHEK2

  • checkpoint kinase 2 (CHEK2) Elisa Kit
  • CHK2 checkpoint homolog (S. pombe) (chek2) Elisa Kit
  • checkpoint kinase 2 (Chek2) Elisa Kit
  • CHK2 checkpoint homolog (S. pombe) (CHEK2) Elisa Kit
  • serine/threonine-protein kinase chk2 (MCYG_07308) Elisa Kit
  • blue sensitive cone opsin (LOC396525) Elisa Kit
  • Cds1 Elisa Kit
  • CHK-2 Elisa Kit
  • Chk2 Elisa Kit
  • fa66f08 Elisa Kit
  • hCds1 Elisa Kit
  • HUCDS1 Elisa Kit
  • LFS2 Elisa Kit
  • PP1425 Elisa Kit
  • Rad53 Elisa Kit
  • wu:fa66f08 Elisa Kit
  • zgc:55865 Elisa Kit

Bezeichner auf Proteinebene für Checkpoint Kinase 2 (CHEK2) ELISA Kits

CHK2 checkpoint homolog , cds1 homolog , checkpoint-like protein CHK2 , serine/threonine-protein kinase Chk2 , protein kinase CHK2 , checkpoint and tumor suppressor protein 2 , Cds1 homolog , Rad53 homolog , protein kinase Chk2 , CHK2 checkpoint homolog (S. pombe) , serine/threonine-protein kinase Chk2-like , serine/threonine-protein kinase chk2 , blue cone photoreceptor pigment , blue-sensitive opsin , opsin CHK-2

11200 Homo sapiens
486338 Canis lupus familiaris
458733 Pan troglodytes
100192447 Sus scrofa
336998 Danio rerio
768913 Gallus gallus
50883 Mus musculus
114212 Rattus norvegicus
100059288 Equus caballus
100404949 Callithrix jacchus
100467146 Ailuropoda melanoleuca
100594542 Nomascus leucogenys
9226831 Arthroderma otae CBS 113480
396525 Gallus gallus
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