CHEK2 Produkte
(Checkpoint Kinase 2 (CHEK2))
Kategorien
In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012].
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Ausgewählte CHEK2 Kategorien
CHEK2 Antikörper
High quality antibodies with extensive validation data.
CHEK2 ELISA Kits
Reliable ELISA kits for a wide range of species.
CHEK2 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene CHEK2 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
WB, ELISA, IHC, IF, ICC
Validierungen
- (1)
- (10)
Kat. Nr.
ABIN6256554
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IF, IHC (p), FACS
Validierungen
- (5)
- (5)
Kat. Nr.
ABIN1881196
Menge
400 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IP
Validierungen
- (7)
Kat. Nr.
ABIN950070
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene CHEK2 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Qualitative Cell ELISA
Validierungen
Kat. Nr.
ABIN1380543
Menge
2 x 96 tests
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validierungen
Kat. Nr.
ABIN1380343
Menge
2 x 96 tests
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validierungen
Kat. Nr.
ABIN1380544
Menge
2 x 96 tests
Datenblatt
Datenblatt
Empfohlene CHEK2 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (2)
- (1)
Kat. Nr.
ABIN1349305
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1349307
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Baculovirus infected Insect Cells
Validierungen
- (1)
Kat. Nr.
ABIN7317121
Menge
50 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren CHEK2 Produkten
: "Garlic Extract Alleviates Trastuzumab-Induced Hepatotoxicity in Rats Through Its Antioxidant, Anti-Inflammatory, and Antihyperlipidemic Effects." in: Journal of inflammation research, Vol. 14, pp. 6305-6316, (2021) (PubMed).: "Silica nanoparticle exposure inducing granulosa cell apoptosis and follicular atresia in female Balb/c mice." in: Environmental science and pollution research international, Vol. 25, Issue 4, pp. 3423-3434, (2018) (PubMed).
: "Endosulfan induces cell dysfunction through cycle arrest resulting from DNA damage and DNA damage response signaling pathways." in: The Science of the total environment, Vol. 589, pp. 97-106, (2017) (PubMed).
: "Deficiency of 53BP1 inhibits the radiosensitivity of colorectal cancer." in: International journal of oncology, Vol. 49, Issue 4, pp. 1600-8, (2017) (PubMed).
: "53BP1 loss induces chemoresistance of colorectal cancer cells to 5-fluorouracil by inhibiting the ATM-CHK2-P53 pathway." in: Journal of cancer research and clinical oncology, Vol. 143, Issue 3, pp. 419-431, (2017) (PubMed).
: "1,2:5,6-dianhydrogalactitol inhibits human glioma cell growth in vivo and in vitro by arresting the cell cycle at G2/M phase." in: Acta pharmacologica Sinica, Vol. 38, Issue 4, pp. 561-570, (2017) (PubMed).
: "ATM Signaling Pathway Is Implicated in the SMYD3-mediated Proliferation and Migration of Gastric Cancer Cells." in: Journal of gastric cancer, Vol. 17, Issue 4, pp. 295-305, (2017) (PubMed).
: "New origin firing is inhibited by APC/CCdh1 activation in S-phase after severe replication stress." in: Nucleic acids research, Vol. 44, Issue 10, pp. 4745-62, (2016) (PubMed).
: "The molecular mechanism of G2M cell cycle arrest induced by AFB1 in the jejunum." in: Oncotarget, Vol. 7, Issue 24, pp. 35592-35606, (2016) (PubMed).
: "Centrosome aberrations in human mammary epithelial cells driven by cooperative interactions between p16INK4a deficiency and telomere-dependent genotoxic stress." in: Oncotarget, Vol. 6, Issue 29, pp. 28238-56, (2015) (PubMed).
Synonyme und alternative Namen zu CHEK2
checkpoint kinase 2 (CHEK2), checkpoint kinase 2 (chek2), checkpoint kinase 2 (Chek2), serine/threonine-protein kinase chk2 (MCYG_07308), checkpoint kinase 2 L homeolog (chek2.L), CDS1, Cds1, cds1, chek2, CHK2, Chk2, chk2, fa66f08, hCds1, HuCds1, HUCDS1, hucds1, LFS2, lfs2, PP1425, pp1425, RAD53, Rad53, rad53, wu:fa66f08, zgc:55865Bezeichner auf Proteinebene für CHEK2
- CHK2 checkpoint homolog
- cds1 homolog
- checkpoint-like protein CHK2
- serine/threonine-protein kinase Chk2
- protein kinase CHK2
- checkpoint and tumor suppressor protein 2
- Cds1 homolog
- Rad53 homolog
- protein kinase Chk2
- CHK2 checkpoint homolog (S. pombe)
- serine/threonine-protein kinase Chk2-like
- serine/threonine-protein kinase chk2
- checkpoint kinase 2 L homeolog
- protein kinase Cds1
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