Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Weitere Synonyme anzeigen
Wählen Sie die gewünschte Spezies
a significant protein-protein interaction between GR and CHOP (zeige DDIT3 Proteine), (GR-CHOP (zeige DDIT3 Proteine) heterocomplex formation) under endoplasmic reticulum stress conditions, is reported.
This study identifies an endocrine developmental axis in which fetal GR primes the activity of PPARalpha (zeige PPARA Proteine) in anticipation of the sudden shifts in postnatal nutrient source and metabolic demands.
Skin differentiation is impaired, and both apoptosis and cell proliferation are augmented in the absence of p23 (zeige CDK5R1 Proteine); the consequences are a severe thinning of the stratum corneum and reduced numbers of hair follicles. Since the phenotype of p23 (zeige CDK5R1 Proteine)-null embryos is strikingly similar to that of embryos lacking the glucocorticoid receptor, a paradigmatic Hsp90 (zeige HSP90 Proteine)-p23 (zeige CDK5R1 Proteine) client protein, we investigated glucocorticoid signaling.
REV-ERBalpha (zeige NR1D1 Proteine) binds to the C-terminal portion and GR to the N-terminal portion of HSP90alpha (zeige HSP90AA2 Proteine) and HSP90beta (zeige HSP90AB1 Proteine), a chaperone responsible for the activation of proteins to ensure survival of a cell.
Phospho-AMPK (zeige PRKAA1 Proteine) is a molecular switch able to cooperate with glucocorticoid receptors and Ppar-alpha (zeige PPARA Proteine) at the chromatin level, a novel adaptation mechanism to prolonged fasting.
GR signaling decreases NRF2 (zeige NFE2L2 Proteine) transcriptional activation through reducing the NRF2 (zeige NFE2L2 Proteine)-dependent histone acetylation. Consistent with these observations, GR signaling blocked NRF2 (zeige NFE2L2 Proteine)-mediated cytoprotection from oxidative stress.
GRbeta antagonizes the GC-induced signaling during fasting via GRalpha and the PPARalpha (zeige PPARA Proteine)-FGF21 (zeige FGF21 Proteine) axis that reduces fat burning. Furthermore, hepatic GRbeta increases inflammation, which leads to hepatic lipid accumulation.
liver-specific deletion of GR resulted in a significant increase in mRNA expression of key genes involved in gluconeogenesis and glycogen (zeige GYS1 Proteine) metabolism in kidney tissue, indicating a compensatory mechanism to maintain glucose homeostasis. Liver GRKO mice demonstrated decreased fat mass and liver glycogen (zeige GYS1 Proteine) content compared with WT mice administered dexamethasone for 2 weeks.
These results established a novel role for GR and KLF13 (zeige KLF13 Proteine) signaling in adult cardiomyocytes with potential clinical implications for the prevention of cardiotoxicity induced heart failure.
miR (zeige MLXIP Proteine)-433 helps maintain circadian rhythm in osteoblasts by regulating sensitivity to glucocorticoid receptor signaling.
The guinea pig GR-specific mutations within the H1-H3 loop confer global changes within the GR-Hsp90 (zeige HSP90 Proteine) complex that favor FKBP51 (zeige FKBP5 Proteine) repression over FKBP52 (zeige FKBP4 Proteine) potentiation.
A woman with glucocorticoid resistance and her mother had a novel p.Arg477Cys (c.1429C>T) mutation in exon 4 of NR3C1, in the 2dzinc finger of the DNA-binding domain. Its 'in silico' functional effect was assessed using pathogenicity prediction software, being characterized as pathogenic. An unrelated patient had a novel p.His588Leufs*5 (c.1762_1763insTTAC) mutation, in exon 6, in the ligand binding domain.
NR3C1 as an important gene of the hypothalamic-pituitary-adrenal axis seems to be particularly relevant for the pathophysiology of ADHD combined with comorbid CD.
The impact of AKT1 (zeige AKT1 Proteine) on glucocorticoid receptor (GR)-induced transcriptional activity in cooperation with phospho-serine/threonine-binding protein 14-3-3 (zeige YWHAQ Proteine), was examined.
Childhood Maltreatment and MDD are both associated wit haltered DNA methylation (zeige HELLS Proteine) levels in the NR3C1 promoter region, however the location and direction of effects differ between the two exposure.s
This study presents evidence of reduced methylation of NR3C1 in association with childhood maltreatment and depressive, anxiety and substance-use disorders in adults.
genetic association studies in a racially diverse population in North Carolina: Data suggest that an SNP in NR3C1 (rs6191, G3134T, "glucocorticoid receptor beta") is associated with altered gene expression profile in primary macrophages; minor allele frequency is 74% with a higher prevalence in Caucasian non-Hispanic participants.
Decreased DNA methylation (zeige HELLS Proteine) of CpG1 of NR3C1 in high-risk infants may allow for increased binding of transcription factors involved in the stress response, repair and regulation of NR3C1. This may ensure healthy growth in high-risk preterm infants over increasing cortisol levels.
haplotype TAAT of GR might be a protective factor against aggressive behavior, while gene-gene interactions between GR rs1800445 and MR (NR3C2) rs2070951 might be a risk factor for aggressive behavior in the Central South Chinese Han population
Glucocorticoid receptor (GR) is recruited to activator protein-1 (AP-1) target genes in a DNA-binding-dependent manner.
These results indicate that myostatin (zeige MSTN Proteine) mediates maternal low protein diet-induced growth retardation, through epigenetic regulation involving FoxO3 (zeige FOXO3 Proteine) and glucocorticoid receptor binding to its promoter.
Data indicate that higher hepatic glucocorticoid receptor (GR) expression in EHL piglets attributes mainly to the enhanced transcription of GR promoter 1-9/10 from breed-specific interaction of p53 (zeige TP53 Proteine) and specificity protein 1 (Sp1 (zeige SP1 Proteine)).
Tissue specificities, gene expression and induction responsiveness of the porcine NR3C1 gene.
Cloning and dna sequence analysis of the upstream flanking region of the NR3C1 gene in the domestic pig.
Effects of age, weaning and/or social isolation on the expression of genes regulating glucocorticoid response [glucocorticoid receptor).
Glucocorticoid Receptor protein expression in granulosa cells was higher in cysts from animals with spontaneous cystic ovarian disease and adrenocorticotropic hormone-induced cystic ovarian disease than in tertiary follicles from control animals.
Exposure to follicular fluid transiently increased the transcript levels of IL8 (zeige IL8 Proteine) and PTGS2 (zeige PTGS2 Proteine), and decreased the expression of SOD2 (zeige SOD2 Proteine), GPX3 (zeige GPX3 Proteine), DAB2 (zeige DAB2 Proteine), and NR3C1. TNF (zeige TNF Proteine) and IL6 (zeige IL6 Proteine) levels were also decreased while those of NAMPT (zeige NAMPT Proteine) were unaffected.
Bayesian image analysis of dexamethasone and shear stress-induced glucocorticoid receptor intracellular movement
investigation of gene expression for GR, 11HSD1, and 11HSD2 (zeige HSD11B2 Proteine) in granulosa cells and theca interna layers during follicular maturation and atresia: expression of GR was largely unchanged during follicular maturation
The E domain of the trout receptors are not involved in the nucleocytoplasmic localization of naive trout GRs (zeige GARS Proteine), but the A/B domain, especially if linked to the corresponding trout CD region, plays a pivotal role in the cellular distribution pattern.
This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175).
, nuclear receptor subfamily 3, group C, member 1
, glucocorticoid receptor 1
, nuclear receptor subfamily 3 group C member 1
, glucocorticoid nuclear receptor variant 1
, glucocorticoid receptor alpha
, glucocorticoid receptor variant P
, glucocorticoid receptor variant beta
, glucocorticoid receptor variant gamma