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FS proteins may also function in facilitating ligand diffusion. We find that mutants of daw are rescued in significant numbers by expression of vertebrate follistatin (FS) proteins
Follistatin and activin A are higher in MI than in CAD suggesting increased release due to myocardial necrosis. They can predict MI with accuracy similar to CK-MB
The activin-A (zeige INHBA Proteine) to follistatin ratio may play a role in determining the clinical phenotype of preterm birth as preterm labor or preterm premature rupture of membranes.
Low follistatin expression is associated with liver cirrhosis.
Follistatin levels are associated with circulating leptin (zeige LEP Proteine) levels and display a day-night rhythm and a menstrual cycle, but not a seasonal, variation.
Within the nonalcoholic fatty liver disease group of patients, follistatin was associated with steatohepatitis independently from activin A (zeige INHBA Proteine)
annexin A2 (zeige ANXA2 Proteine) but not follistatin is expressed in hepatocellular carcinoma
FST plays a role in tumourigenesis, metastasis and angiogenesis of solid tumours through its interaction with activin and BMPs, thus resulting in pathophysiological function. In terms of diagnosis, prognosis and therapy, FST has shown strong promise
Study shows that INHBA (zeige INHBA Proteine) and FST are induced by seminal fluid in cervical tissues and thus, may contribute to regulation of the post-coital response in women.
Circulating follistatin may be a marker of the glucagon (zeige GCG Proteine)-to-insulin (zeige INS Proteine) tone on the liver
We report here an original observation that activin-B is upregulated in the human idiopathic pulmonary fibrosis lung.
Response to selection for increased litter size could not be attributed to effects at the estrogen receptor (zeige ESR1 Proteine), retinol-binding protein or follistatin loci.
Data suggest that SMAD4 (SMAD family member 4 (zeige SMAD4 Proteine)) mRNA is increased in oocytes during maturation, is maximal in 2-cell blastocysts, remains elevated through 8-cell stage, and then decreases; embryotrophic actions of FST are SMAD4 (zeige SMAD4 Proteine) dependent.
The expression of the components of the activin-inhibin-follistatin system is altered in bovine cystic ovarian disease.
A functional role for oocyte-derived follistatin in bovine early embryogenesis.
Fst promotes brown adipocyte characteristics in both white adipose tissue and brown adipose tissue depots in vivo through distinct mechanisms.
Results showed activin-C and follistatin are differentially expressed during prostate development and suggested that the antagonistic property of follistatin is secondary to the action of activin-C. Study provides evidence to support a role of activin-C in prostate development and provides new insights in the spatiotemporal localization of activins and their antagonists during mouse prostate development.
Oviducts of tghFST315 mice failed to coil, the myometrium was disorganised, endometrial gland number was reduced and oviducts and uteri contained abundant leukocytes. These studies show that follistatin is crucial to postnatal oviductal-uterine development and function.
OVOL1 (zeige OVOL1 Proteine)-regulated Fst and SFRP1 (zeige SFRP1 Proteine) affect hair inductive potency of neonatal dermal cells.
This study assesses the regulation of activin A (zeige INHBA Proteine) and follistatin in a murine myocardial ischaemia-reperfusion model.
Results implicate a role of follistatin (Fst) in the induction of brown adipocyte character and regulation of energy metabolism.
follistatin induces hair wave propagation and its level decreases in aging mice.
Follistatin aids in maintaining proper somite size, and consequently sclerotome progenitor numbers, by preventing paraxial mesoderm from adopting an intermediate/lateral plate mesodermal fate in the Noggin (zeige NOG Proteine)-deficient state.
Report role of activin A (zeige INHBA Proteine)-myostatin (zeige MSTN Proteine)-follistatin system on aging bone and muscle progenitor cells.
Data from transgenic mice suggest that overexpression of follistatin negatively influences bone metabolism decreasing all measured biomechanical strength parameters in developing bone.
Roles of follistatin 1 in regulation of zebrafish fecundity and sexual differentiation.
Results suggest that Follistatin 1 overexpression can promote zebrafish muscle growth by enhancing myofiber hyperplasia.
Follistatin increased with growth of ovary. Increased significantly during vitellogenesis. Gradually increased during daily ovulatory cycle.
fst, a bone morphogenetic protein antagonist expressed in gastrulation, is dispensable for neural crest induction.
Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin.
, follistatin 1
, activin-binding protein
, follistatin isoform FST317
, follistatin A