anti-EIF4EBP1 (EIF4EBP1) Antikörper

Bezeichnung:
anti-Eukaryotic Translation Initiation Factor 4E Binding Protein 1 Antikörper (EIF4EBP1)
Auf www.antikoerper-online.de finden Sie aktuell 491 Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1) Antikörper von 28 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen EIF4EBP1 Proteine (24) und EIF4EBP1 Kits (20) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 557 EIF4EBP1 Produkte verfügbar.
Synonyme:
4e-bp, 4e-bp1, 4ebp, 4EBP1, 43-BP, 153432_at, AA959816, anon-WO0172774.158, BcDNA.HL08053, BcDNA:HL08053, BP-1, CG8846, CT8705, d4e-bp, d4E-BP1, d4eBP, Dm 4E-BP, Dmel\\CG8846, dthor, eIF4E-BP, EIF4EBP1, fc04h09, l(2)06270, l(2)k07736, l(2)k13517, PHAS-I, Phas1, pp20, thor, Thor/EIF4EBP, wu:fc04h09, zgc:64137
Alle Antikörper anzeigen Gen GeneID UniProt
EIF4EBP1 1978 Q13541
EIF4EBP1 13685 Q60876
EIF4EBP1 116636 Q62622

Alle Spezies anzeigen

Weitere Synonyme anzeigen

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Am meisten referenzierte anti-EIF4EBP1 Antikörper

  1. Human Polyclonal EIF4EBP1 Primary Antibody für EIA - ABIN358355 : Fonseca, Smith, Lee, MacKintosh, Proud: PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex. in The Journal of biological chemistry 2007 (PubMed)
    Zeige alle 2 Referenzen für 358355

  2. Human Polyclonal EIF4EBP1 Primary Antibody für IHC (p), WB - ABIN197450 : de Vetten, Quattrocchio, Mol, Koes: The an11 locus controlling flower pigmentation in petunia encodes a novel WD-repeat protein conserved in yeast, plants, and animals. in Genes & development 1997 (PubMed)
    Zeige alle 2 Referenzen für 197450

  3. Human Polyclonal EIF4EBP1 Primary Antibody für FACS, IHC (p) - ABIN656558 : She, Halilovic, Ye, Zhen, Shirasawa, Sasazuki, Solit, Rosen: 4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors. in Cancer cell 2010 (PubMed)
    Zeige alle 2 Referenzen für 656558

  4. Human Monoclonal EIF4EBP1 Primary Antibody für WB - ABIN659184 : Aoyagi, Gaspar, Shenk: Human cytomegalovirus UL69 protein facilitates translation by associating with the mRNA cap-binding complex and excluding 4EBP1. in Proceedings of the National Academy of Sciences of the United States of America 2010 (PubMed)
    Zeige alle 2 Referenzen für 659184

  5. Human Polyclonal EIF4EBP1 Primary Antibody für IHC (p), WB - ABIN388707 : Armengol, Rojo, Castellví, Iglesias, Cuatrecasas, Pons, Baselga, Ramón y Cajal: 4E-binding protein 1: a key molecular "funnel factor" in human cancer with clinical implications. in Cancer research 2007 (PubMed)
    Zeige alle 2 Referenzen für 388707

  6. Human Polyclonal EIF4EBP1 Primary Antibody für IHC, ELISA - ABIN1532119 : Pause, Belsham, Gingras, Donzé, Lin, Lawrence, Sonenberg: Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function. in Nature 1994 (PubMed)

Weitere Antikörper gegen EIF4EBP1 Interaktionspartner

Fruit Fly (Drosophila melanogaster) Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1) Interaktionspartner

  1. GCN2 and ATF4 are important regulators of 4E-BP transcription during normal drosophila development and aging.

  2. longevity assurance mutants of chico, the Drosophila insulin receptor (zeige INSR Antikörper) substrate homolog, require Drosophila d4eBP to slow aging.

  3. These results indicate that the Ccr4-Not complex controls expression of 4E-BP at multiple levels and adjusts the magnitude of the total effect.

  4. eIF4E-binding protein requires non-canonical 4E-binding motifs and a lateral surface of eIF4E (zeige EIF4E Antikörper) to repress translation.

  5. PcG proteins can directly modulate cell growth in Drosophila, in part by regulating Thor expression

  6. These findings reveal an organism-wide regulation of proteostasis in response to muscle aging and a key role of FOXO/4E-BP signaling in the coordination of organismal and tissue aging.

  7. Induction of 4EBP likely leads to growth inhibition by Dfoxo (zeige FOXO Antikörper), whereas activation of InR (zeige INSR Antikörper) provides a novel transcriptionally induced feedback control mechanism.

  8. S6 kinase (dS6K) and a single 4E-BP (d4E-BP) are phosphorylated via the insulin and target of rapamycin (TOR) signaling pathways.

  9. Drosophila 4E-BP activity becomes critical for survival under dietary restriction and oxidative stress, and is linked to life span.

  10. Analysis of Drosophila 4E-BP(null) mutant survival upon infection with C. albicans showed that 4E-BP plays an important role in host defense.

Pig (Porcine) Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1) Interaktionspartner

  1. Arg, Leu, and Gln act coordinately to stimulate proliferation of pTr (zeige PTCHD3 Antikörper) cells through activation of the MTOR (zeige FRAP1 Antikörper)-RPS6K-RPS6 (zeige RPS6 Antikörper)-EIF4EBP1 signal transduction pathway.

Human Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1) Interaktionspartner

  1. There were significantly higher expressions of p-eIF4E (zeige EIF4E Antikörper) and p-4EBP-1 proteins in the cases with lymph node metastasis than in those without lymph node metastasis.

  2. 4E-BP1 has tumor suppressor activity by inhibiting eIF4E (zeige EIF4E Antikörper) and, thus, blocking mRNA translation and proliferation. This is corroborated by elevated levels of phosphorylated and hence inactive 4E-BP1, which are detected in various cancers

  3. Rotterlin inhibits mTORC1 and 4EBP1 activity in melanoma cells, inhibiting protein synthesis and promoting cell death.

  4. Inhibition of mTORC1-mediated 4EBP1 phosphorylation leads to decreased expression of c-MYC (zeige MYC Antikörper) and subsequent upregulation of the proapoptotic BCL2 (zeige BCL2 Antikörper) family member PUMA (zeige BBC3 Antikörper), whereas inhibition of mTORC2 (zeige CRTC2 Antikörper) results in nuclear factor-kappaB-mediated expression of the Early Growth Response 1 (EGR1 (zeige EGR1 Antikörper)) gene, which encodes a transcription factor that binds and transactivates the proapoptotic BCL2L11 (zeige BCL2L11 Antikörper) locus encoding BIM (zeige BCL2L11 Antikörper).

  5. p-4E-BP1 is more highly expressed in early gastric cancers than in advanced ones, and has limited potential as an independent prognostic biomarker in patients with gastric cancer.

  6. this study shows that anticancer activity of perillyl alcohol is mediated via inhibition of 4E-BP1 signaling

  7. 4EBP1 may serve as a funnel factor that converge the upstream proliferative oncogenic signals.

  8. Increased expression of miR (zeige MLXIP Antikörper)-125a is associated with invasion and migration in ovarian cancer.

  9. 4E-BP1 was shown to be phosphorylated by other kinases besides mTOR (zeige FRAP1 Antikörper), and overexpression of 4E-BP1 was found in different human carcinomas. (Review)

  10. Twist1 (zeige TWIST1 Antikörper) is correlated with p-4E-BP1 in predicting the prognostic outcome of NSCLC.

Mouse (Murine) Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1) Interaktionspartner

  1. The authors now show that West Nile virus growth and protein expression are dependent on mTORC1 mediated-regulation of the eukaryotic translation initiation factor 4E-binding protein/eukaryotic translation initiation factor 4E-binding protein (4EBP/eIF4E (zeige EIF4E Antikörper)) interaction and eukaryotic initiation factor (zeige EIF4G1 Antikörper) 4F (eIF4F (zeige EIF4A2 Antikörper)) complex formation to support viral growth and viral protein expression.

  2. p-mTOR, p-4EBP1, HIF-1alpha and VEGF together are involved in the pathogenesis of asthma.

  3. Thus, translational control by 4E-BP1 downstream of mTOR (zeige FRAP1 Antikörper) effects the expression of neuroligin 1 (zeige NLGN1 Antikörper) and excitatory synaptic transmission in the spinal cord, and thereby contributes to enhanced mechanical nociception.

  4. The findings support a model whereby elevated 4E-BP1 expression observed in the retina of diabetic rodents is the result of O-GlcNAcylation of 4E-BP1 within its PEST motif.

  5. The mTORC1 effectors S6K1 and 4E-BP play different roles in CNS axon regeneration.

  6. Oxidative stress-induced (zeige SQSTM1 Antikörper) premature senescence occurred due to impaired autophagy function through 4EBP1 phosphorylation.

  7. Data show that deletion of eukaryotic translation initiation factor 4E-binding protein 1/2 (4E-BP1/2) in erythroid cells rendered them resistant to mammalian target of rapamycin complex 1 (TORC1) inhibition and restored hemoglobin production.

  8. Rotenone induction of hydrogen peroxide inhibits mTOR (zeige FRAP1 Antikörper)-mediated S6K1 (zeige RPS6KB1 Antikörper) and 4E-BP1/eIF4E (zeige EIF4E Antikörper) pathways, resulting in caspase (zeige CASP3 Antikörper)-dependent and -independent apoptosis in neuronal cells.

  9. These findings indicate that regulation of 4E-BP1 in skeletal muscle may serve as an important conduit through which mTORC1 controls metabolism.

  10. Disruption of genes encoding Eif4ebp1 and Eif4ebp2 (zeige EIF4EBP2 Antikörper) does not alter basal or sepsis-induced changes in skeletal muscle protein synthesis in male or female mice.

EIF4EBP1 Antigen-Profil

Beschreibung des Gens

This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.

Alternative names and synonyms associated with EIF4EBP1

  • CG8846 gene product from transcript CG8846-RA (Thor) Antikörper
  • eukaryotic translation initiation factor 4E binding protein 1 (EIF4EBP1) Antikörper
  • eukaryotic translation initiation factor 4E binding protein 1 (eif4ebp1) Antikörper
  • eukaryotic translation initiation factor 4E binding protein 1 (LOC100230789) Antikörper
  • eukaryotic translation initiation factor 4E binding protein 1 (Eif4ebp1) Antikörper
  • 4e-bp Antikörper
  • 4e-bp1 Antikörper
  • 4ebp Antikörper
  • 4EBP1 Antikörper
  • 43-BP Antikörper
  • 153432_at Antikörper
  • AA959816 Antikörper
  • anon-WO0172774.158 Antikörper
  • BcDNA.HL08053 Antikörper
  • BcDNA:HL08053 Antikörper
  • BP-1 Antikörper
  • CG8846 Antikörper
  • CT8705 Antikörper
  • d4e-bp Antikörper
  • d4E-BP1 Antikörper
  • d4eBP Antikörper
  • Dm 4E-BP Antikörper
  • Dmel\\CG8846 Antikörper
  • dthor Antikörper
  • eIF4E-BP Antikörper
  • EIF4EBP1 Antikörper
  • fc04h09 Antikörper
  • l(2)06270 Antikörper
  • l(2)k07736 Antikörper
  • l(2)k13517 Antikörper
  • PHAS-I Antikörper
  • Phas1 Antikörper
  • pp20 Antikörper
  • thor Antikörper
  • Thor/EIF4EBP Antikörper
  • wu:fc04h09 Antikörper
  • zgc:64137 Antikörper

Bezeichner auf Proteinebene für EIF4EBP1

CG8846-PA , Eif4e-binding protein , Thor-PA , eIF-4E-binding protein , eif4e-binding protein 4EBP , eukaryotic initiation factor 4E binding protein , eukaryotic initiation factor 4E-binding protein , eukaryotic translation initiation factor 4E binding protein , eukaryotic translation initiation factor 4E-binding protein , insulin-stimulated eIF-4E binding protein , lethal (2) 06270 , thor , eukaryotic translation initiation factor 4E binding protein 1 , translation initiation factor 4E binding protein 1 , eukaryotic translation initiation factor 4E-binding protein 1 , eIF4E-binding protein 1 , phosphorylated heat- and acid-stable protein regulated by insulin 1 , 4E-BP1

GENE ID SPEZIES
33569 Drosophila melanogaster
397633 Sus scrofa
464114 Pan troglodytes
703628 Macaca mulatta
799566 Danio rerio
100230789 Taeniopygia guttata
1978 Homo sapiens
13685 Mus musculus
116636 Rattus norvegicus
426773 Gallus gallus
475590 Canis lupus familiaris
100627508 Sus scrofa
509613 Bos taurus
Ausgewählte Anbieter für anti-EIF4EBP1 (EIF4EBP1) Antikörper
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