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anti-Mouse (Murine) DAP Kinase 1 Antikörper:
anti-Rat (Rattus) DAP Kinase 1 Antikörper:
anti-Human DAP Kinase 1 Antikörper:
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Human Monoclonal DAP Kinase 1 Primary Antibody für IF, IP - ABIN967885
Cohen, Feinstein, Kimchi: DAP-kinase is a Ca2+/calmodulin-dependent, cytoskeletal-associated protein kinase, with cell death-inducing functions that depend on its catalytic activity. in The EMBO journal 1997
Show all 2 Pubmed References
Human Monoclonal DAP Kinase 1 Primary Antibody für IF, IP - ABIN967884
Deiss, Feinstein, Berissi, Cohen, Kimchi: Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death. in Genes & development 1995
Show all 2 Pubmed References
Human Monoclonal DAP Kinase 1 Primary Antibody für IP, MA - ABIN265776
Hearnden, Powers, Elmogassabi, Lowe, Murdoch: Methyl-donor depletion of head and neck cancer cells in vitro establishes a less aggressive tumour cell phenotype. in European journal of nutrition 2017
Human Polyclonal DAP Kinase 1 Primary Antibody für IF (p), IHC (p) - ABIN732983
Liu, Ao, Zhou, Cui, Zhou, Yuan, Xiang, Cao, Liu: CpG island hypermethylation of multiple tumor suppressor genes associated with loss of their protein expression during rat lung carcinogenesis induced by 3-methylcholanthrene and diethylnitrosamine. in Biochemical and biophysical research communications 2010
Inhibition of DAPK1 by deleting a catalytic domain or a death domain of DAPK1 rescues the Excitatory pyramidal neurons in the entorhinal cortical layer II region synaptic loss
in Alzheimer's disease (AD) brains, elevated DAPK1 levels showed co-relation with the increase of APP (zeige APP Antikörper) phosphorylation. Combined together, these results suggest that DAPK1 promotes the phosphorylation and amyloidogenic processing of APP (zeige APP Antikörper), and that may serve a potential therapeutic target for AD.
This study demonstrate that phosphorylation of Tau at Serine 262 by the kinase domain of DAPK1 mediates spine damage and the subsequent neuronal death in ischemic stroke.
DAPK1-p53 (zeige TP53 Antikörper) interaction is a preferred target for therapeutic intervention of stroke.
Suggest that DAPK1 is a novel regulator of tau protein abundance, and that DAPK1 upregulation might contribute to tau-related pathologies in Alzheimer disease.
the DAPK1-p53 (zeige TP53 Antikörper) interaction is a signaling point of convergence of necrotic and apoptotic pathways
a new function of DAPK in suppressing TNF (zeige TNF Antikörper)-induced STAT3 (zeige STAT3 Antikörper) activation, was identified.
TSC2 (zeige TSC2 Antikörper) binds to the death domain of DAPK. This interaction is required for TSC2 (zeige TSC2 Antikörper) to reduce DAPK protein levels and half-life. DAPK is regulated by the lysosome pathway. Lysosome inhibition blocks TSC2 (zeige TSC2 Antikörper)-mediated degradation of DAPK.
Results identify DAPK as a molecule required for full production of IL-1beta (zeige IL1B Antikörper) and functional assembly of the NLRP3 (zeige NLRP3 Antikörper) inflammasome.
Study reports that cerebral ischemia recruits death-associated protein kinase 1 (DAPK1) into the NMDA receptor NR2B (zeige GRIN2B Antikörper) protein complex in the cortex of adult mice.
The current study supports a relevant role for p15 (zeige CDKN2B Antikörper), p16 (zeige CDKN2A Antikörper), and DAPK hypermethylation in the genesis of the plasma cell neoplasm. DAPK hypermethylation also might be an important step in the progression from MGUS to MM.
DAPK1 methylation is associated with the risk of gastrointestinal cancer.
downregulation of HOXC9 (zeige HOXC9 Antikörper) releases its transcriptional inhibition of DAPK1, resulting in the activation of the DAPK1-Beclin1 (zeige BECN1 Antikörper) pathway, which induces autophagy in glioblastoma cells
findings evidence a positive correlation between SIRT1 (zeige SIRT1 Antikörper) and BCL6 (zeige BCL6 Antikörper) expression increase in follicular lymphomas (FL) . SIRT1 (zeige SIRT1 Antikörper) methylation decreases in FL and diffuse large-B cell lymphomas (DLBCL)and this parallels the increase of KLF4 (zeige KLF4 Antikörper), DAPK1 and SPG20 (zeige SPG20 Antikörper) methylation
results suggest that DAPK1 is an important prognostic marker and therapeutic target for bladder cancer and have identified possible therapeutic agents for future testing in bladder cancer models with low DAPK1 expression
Study provides evidence that DAPK1 is a negative-feedback regulator of the RIG-I (zeige DDX58 Antikörper) pathway. RIG-I (zeige DDX58 Antikörper)-mediated antiviral signaling activates DAPK1 kinase activity and DAPK1 inactivates RIG-I (zeige DDX58 Antikörper) RNA sensing by direct phosphorylation of RIG-I (zeige DDX58 Antikörper).
Meta-analysis suggested that aberrant methylation of DAPK promoter was associated with head and neck squamous cell carcinoma.
our study characterized DAPK1 as a novel transcriptional target of BRMS1 (zeige BRMS1 Antikörper). Transcriptional activation of DAPK1 might be another important mechanism accounting for the metastasis suppressive activity of BRMS1 (zeige BRMS1 Antikörper).
The result suggests that DAPK promoter methylation is significantly increased in bladder cancer patients compared to normal controls. DAPK promoter methylation could serve as a biomarker for bladder cancer detection and management.
Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate.
death-associated protein kinase 1
, death-associated protein kinase 1-like
, DAP kinase 1