Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

DAP Kinase 1 Antikörper (Internal Region)

DAPK1 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6261221
  • Target Alle DAP Kinase 1 (DAPK1) Antikörper anzeigen
    DAP Kinase 1 (DAPK1) (Death-Associated Protein Kinase 1 (DAPK1))
    Bindungsspezifität
    • 15
    • 9
    • 9
    • 8
    • 8
    • 7
    • 7
    • 7
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reaktivität
    • 85
    • 41
    • 4
    • 3
    • 2
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 82
    • 3
    Kaninchen
    Klonalität
    • 80
    • 5
    Polyklonal
    Konjugat
    • 30
    • 8
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser DAP Kinase 1 Antikörper ist unkonjugiert
    Applikation
    • 58
    • 37
    • 21
    • 13
    • 13
    • 10
    • 10
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Spezifität
    DAPK1 Antibody detects endogenous levels of total DAPK1.
    Homologie
    Pig,Zebrafish,Bovine,Horse,Rabbit,Dog,Chicken,Xenopus
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human DAPK1, corresponding to a region within the internal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product DAPK1 Primärantikörper
  • Applikationshinweise
    WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    DAP Kinase 1 (DAPK1) (Death-Associated Protein Kinase 1 (DAPK1))
    Andere Bezeichnung
    DAPK1 (DAPK1 Produkte)
    Synonyme
    DAPK1 antikoerper, MGC81366 antikoerper, si:ch211-66i11.1 antikoerper, wu:fj09c03 antikoerper, dapk antikoerper, MGC83745 antikoerper, 2310039H24Rik antikoerper, 2810425C21Rik antikoerper, AI642003 antikoerper, D13Ucla1 antikoerper, DAP-Kinase antikoerper, DAPK antikoerper, death-associated protein kinase 1 antikoerper, death associated protein kinase 1 L homeolog antikoerper, death associated protein kinase 1 antikoerper, death associated protein kinase 1 S homeolog antikoerper, LOC427465 antikoerper, dapk1.L antikoerper, DAPK1 antikoerper, dapk1 antikoerper, dapk1.S antikoerper, Dapk1 antikoerper
    Hintergrund

    Description: Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress fiber formation in endothelial cells. Phosphorylates STX1A and significantly decreases its binding to STXBP1. Phosphorylates PRKD1 and regulates JNK signaling by binding and activating PRKD1 under oxidative stress. Phosphorylates BECN1, reducing its interaction with BCL2 and BCL2L1 and promoting the induction of autophagy. Phosphorylates TSC2, disrupting the TSC1-TSC2 complex and stimulating mTORC1 activity in a growth factor-dependent pathway. Phosphorylates RPS6, MYL9 and DAPK3. Acts as a signaling amplifier of NMDA receptors at extrasynaptic sites for mediating brain damage in stroke. Cerebral ischemia recruits DAPK1 into the NMDA receptor complex and it phosphorylates GRINB at Ser-1303 inducing injurious Ca2+ influx through NMDA receptor channels, resulting in an irreversible neuronal death. Required together with DAPK3 for phosphorylation of RPL13A upon interferon-gamma activation which is causing RPL13A involvement in transcript-selective translation inhibition.

    Gene: DAPK1

    Molekulargewicht
    160kDa
    Gen-ID
    1612
    UniProt
    P53355
    Pathways
    MAPK Signalweg, Interferon-gamma Pathway
Sie sind hier:
Kundenservice