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anti-Human PIP4K2A Antikörper:
anti-Mouse (Murine) PIP4K2A Antikörper:
anti-Rat (Rattus) PIP4K2A Antikörper:
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Human Polyclonal PIP4K2A Primary Antibody für IHC (p), WB - ABIN392598
Wilcox, Hinchliffe: Regulation of extranuclear PtdIns5P production by phosphatidylinositol phosphate 4-kinase 2alpha. in FEBS letters 2008
Show all 5 Pubmed References
the rs7088318 (PIP4K2A) and rs2239633 (CEBPE (zeige CEBPE Antikörper)) polymorphisms were not associated with ALL risk.
PIP5K2A is possibly involved in a mechanism protecting against tardive dyskinesia-inducing neurotoxicity.
The diplotype ATTGCT/ATTGCT of the PIP4K2A gene confers approximately three-times higher incomplete responsiveness towards antipsychotics in severely ill patients.
PIP4K2A to be essential for the clonogenic and leukemia-initiating potential of human AML (zeige RUNX1 Antikörper) cells, and for the clonogenic potential of murine MLL (zeige MLL Antikörper)-AF9 (zeige MLLT3 Antikörper) AML (zeige RUNX1 Antikörper) cells.
We also showed that PIPKIIalpha silencing can induce alpha and gamma globin expression and decrease cell proliferation in K562 cells.
Overexpression of type 2A PI(4)P5-kinase (PIP5K (zeige PIKFYVE Antikörper) 2A) significantly reduced tamoxifen inhibition of Kv7.2 (zeige KCNQ2 Antikörper)/Kv7.3 (zeige KCNQ3 Antikörper) and Kv7.2 (zeige KCNQ2 Antikörper) R463Q channels.
The data suggest that PI5P4Ka N251S does not significantly differ in activity from the wild-type enzyme, throwing a new light on its association with schizophrenia.
Knocking down PI5P4Kalpha and beta in a breast cancer cell line bearing an amplification of the gene encoding PI5P4K beta and deficient for p53 (zeige TP53 Antikörper) impaired growth on plastic and in xenografts.
Variation at 10p12.2 (PIP4K2A) and 10p14 (GATA3 (zeige GATA3 Antikörper)) influences risk of acute lymphoblastic anemia and tumor subtype. (Meta-analysis)
PIP5K2A variant influences susceptibility to schizophrenia in the Russian population of Siberia. Authors studied 355 patients with schizophrenic disorders from the Russian population of Siberia.
Phosphatidylinositol-5,4-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility. The protein encoded by this gene is one of a family of enzymes capable of catalyzing the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. The amino acid sequence of this enzyme does not show homology to other kinases, but the recombinant protein does exhibit kinase activity. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family.
phosphatidylinositol-4-phosphate 5-kinase, type II, alpha
, phosphatidylinositol-4-phosphate 5-kinase type II alpha
, 1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha
, 1-phosphatidylinositol-4-phosphate kinase
, 1-phosphatidylinositol-5-phosphate 4-kinase 2-alpha
, PI(5)P 4-kinase type II alpha
, PtdIns(4)P-5-kinase B isoform
, diphosphoinositide kinase 2-alpha
, phosphatidylinositol 5-phosphate 4-kinase type II alpha
, phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
, phosphatidylinositol-5-phosphate 4-kinase type-2 alpha
, ptdIns(4)P-5-kinase C isoform
, ptdIns(5)P-4-kinase isoform 2-alpha
, type II phosphatidylinositol-4-phosphate 5-kinase 53 K isoform
, 1-phosphatidylinositol-5-phosphate 4-kinase A
, PIPK2 alpha
, phosphatidylinositol-5-phosphate 4-kinase type II alpha