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Lef1 (zeige LEF1 ELISA Kits) and Tcf1 showed oncogenic effect in colonic carcinogenesis. Cellular context of miRNAs might play important roles in carcinogenesis by altering the expression pattern of Lef/Tcfs members.
HNF1alpha, which has previously been described as a modulator of several transporters of the renal transportosome, is also a key determinant of PDZK1 (zeige PDZK1 ELISA Kits) transcription.
Results identified HNF1A/B as a good candidates to master the regulation of pancreatic differentiation, which at the protein level loses its expression in malignant ductal cells of the pancreas, suggesting its putative role as tumor suppressor in pancreatic cancer.
this study found that 20%-60% of Hepatit (zeige CD8A ELISA Kits)is C-specific CD8+ T cells were Tcf1+
Findings suggest that there are subtypes of T2DM characterized by different urinary glucose excretion and cardiovascular risk factors. SLC5A2 (zeige SLC5A2 ELISA Kits) and HNF1A mutations partially explain renal glycosuria in patients with T2DM.
Results indicate that HNF1alpha can modulate the expression of hepatitis B virus (HBV) large surface proteins to interfere virion production, and HNF1alpha is capable of limiting HBV transcription and replication by activating the NF-kappaB (zeige NFKB1 ELISA Kits) signaling.
Study have shown that expression of specific miRNAs depends on HNF1beta (zeige HNF1B ELISA Kits) function. The impact of HNF1beta (zeige HNF1B ELISA Kits) deficiency was evidenced at serum level, making HNF1beta (zeige HNF1B ELISA Kits)-dependent miRNAs potentially applicable in the diagnosis of HNF1B (zeige HNF1B ELISA Kits)-MODY (zeige HNF4A ELISA Kits).
Mutation in HNF1A gene is associated with Maturity Onset Diabetes of the Young.
CRP (zeige CRP ELISA Kits) increased PCSK9 (zeige PCSK9 ELISA Kits) expression by activating p38MAPK (zeige MAPK14 ELISA Kits)-HNF1alpha pathway, with a certain downstream impairment in LDL metabolism in HepG2 cells.
Our data on the first functional study of HNF1A mutations in South India subjects confers that the defect of the HNF-1A mutant proteins are responsible for MODY3 diabetes in these patients
We identified PD-1 (zeige PDCD1 ELISA Kits) to be specifically expressed in PLZF(+) ILCp and revealed that the timing and order of expression of the transcription factors NFIL3 (zeige NFIL3 ELISA Kits), ID2, and TCF-1 was critical. Importantly, induction of ILC (zeige CCL27 ELISA Kits) lineage commitment required only transient expression of NFIL3 (zeige NFIL3 ELISA Kits) prior to ID2 and TCF-1 expression.
Knockdown of MACF1 (zeige MACF1 ELISA Kits) in osteoblastic cells inhibits osteoblast differentiation through suppressing the beta-catenin (zeige CTNNB1 ELISA Kits)/TCF1-Runx2 (zeige RUNX2 ELISA Kits) axis.
this study found that virus-specific CD8 (zeige CD8A ELISA Kits)(+) T cells that sustained the T cell response during chronic viral infection are defined by, and depended on, the expression of Tcf1
data demonstrate a novel miR (zeige MLXIP ELISA Kits)-24-TCF1 pathway in controlling effector cytokine production by T cells and further suggest miR (zeige MLXIP ELISA Kits)-24 could function as a key upstream molecule regulating TCF1-mediated immune responses.
HNF1alpha plays a crucial role in hepatocyte lipid metabolism and hepatocarcinogenesis
Data show that TCF1 proteindeficiency relieved most manifestations of autoimmune lymphoproliferative syndrome (ALPS)-like phenotype, which were caused by Fas (zeige FAS ELISA Kits) protein mutation in TCF1(-/-) lpr/lpr (zeige FAS ELISA Kits) mice.
Data show that the Wnt-effector hepatocyte nuclear factor 1-alpha (Tcf1) is recruited to and triggers transcription of the Ink4/Arf tumor suppressor locus, such as as p15Ink4b, p16Ink4a and p19Arf.
this study shows that distinct, asynchronous and stage-specific transcription factors (TCF-1, GATA-3 (zeige GATA3 ELISA Kits) and Runx1 (zeige RUNX1 ELISA Kits)) activate Bcl11b (zeige BCL11B ELISA Kits) for T cell commitment
this study shows that the transcription factors Tcf1 and Lef1 (zeige LEF1 ELISA Kits) suppress CD4 (zeige CD4 ELISA Kits)+ T lineage genes in CD8 (zeige CD8A ELISA Kits)+ T cells through intrinsic histone deacetylase (zeige HDAC1 ELISA Kits) activity
pigs harboring the dominant-negative mutant human MODY3 gene showed reproducible and distinct glomerular nodules.
The protein encoded by this gene is a transcription factor required for the expression of several liver-specific genes. The encoded protein functions as a homodimer and binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Defects in this gene are a cause of maturity onset diabetes of the young type 3 (MODY3) and also can result in the appearance of hepatic adenomas.
HNF1 homeobox A
, albumin proximal factor
, hepatic nuclear factor 1
, hepatocyte nuclear factor 1-alpha
, interferon production regulator factor
, liver-specific transcription factor LF-B1
, transcription factor 1, hepatic
, hepatic nuclear factor (HNF1)
, transcription factor 1, hepatic; LF-B1, hepatic nuclear factor (HNF1), albumin proximal factor
, hepatocyte nuclear factor 1
, transcription factor 1
, LF-B1 hepatic nuclear factor (HNF1): albumin proximal factor also TCF1
, LF-B1, hepatic nuclear factor (HNF1): albumin proximal factor, also TCF1
, Transcription factor 1 hepatic
, Transcription factor 1, hepatic
, hepatic nuclear factor-1-alpha
, hepatocyte nuclear factor 1 alpha