Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1) Proteine (PRKAR1A)

Bezeichnung:
Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1) Proteine (PRKAR1A)
Auf www.antikoerper-online.de finden Sie aktuell 18 Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1) (PRKAR1A) Proteine von 7 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1) Antikörper (57) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 83 Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1) Produkte verfügbar.
Synonyme:
1300018C22Rik, ACRDYS1, ADOHR, CAR, CNC, CNC1, im:7047729, PKR1, PPNAD1, PRKAR1, prkar1a, RIalpha, RIIA, Tse-1, TSE1, zgc:92515
alle Proteine anzeigen Gen GeneID UniProt
PRKAR1A 19084 Q9DBC7
PRKAR1A 5573 P10644
PRKAR1A 25725 P09456

Weitere Synonyme anzeigen

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Weitere Proteine zu Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1) Interaktionspartnern

Zebrafish Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1) (PRKAR1A) Interaktionspartner

  1. Results demonstrate that PKA activity regulated by Mys is indispensable for negative regulation of the Hh signaling pathway in Hh-responsive cells.

Mouse (Murine) Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1) (PRKAR1A) Interaktionspartner

  1. data demonstrate that haploinsufficiency for either one of the type-II regulatory subunits improved the bone phenotype of mice haploinsufficient for Prkar1a

  2. PRKAR1A gene and its locus are altered in mixed odontogenic tumors. Expression is decreased in a subset of tumors, and Prkar1a(+) (/) (-) mice do not show abnormalities, which indicates that additional genes play a role in this tumor's pathogenesis.

  3. Prkar1a activation enhances beta-catenin (zeige CTNNB1 Proteine) transcriptional activity through nuclear localization to PML (zeige PML Proteine) bodies.

  4. Loss of Prkar1a can only promote tumorigenesis when Prkar1a-mediated apoptosis is somehow countered.

  5. Data show that mammary-specific loss of Prkar1a leads to elevated type-II PKA isozyme activation and this is sufficient to drive breast carcinogenesis.

  6. Results show that mouse Prkar1a and human PRKAR2A (zeige PRKAR2A Proteine) exhibited a dynamic spatio-temporal expression in tooth development, whereas neither human PRKAR1A nor mouse Prkar2a (zeige PRKAR2A Proteine) showed their expression in odontogenesis.

  7. Ablation of Prkar1a interferes with signaling pathways necessary for osteoblast differentiation.

  8. hypoxia/reoxygenation (H/R)-mediated decrease in PKARIalpha protein levels leads to activation of RSK1 (zeige RPS6KA1 Proteine), which via phosphorylation of NHE1 (zeige SLC9A1 Proteine) induces cardiomyocyte apoptosis.

  9. Prkar1a was found to play a critical role in peripheral nerve development.

  10. Dysregulated protein kinase A activity in the amygdala-prefrontal cortex circuitry in Prkar1a(+/-) mice is associated with behavioral phenotype of anxiety and a bias for threat

Human Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1) (PRKAR1A) Interaktionspartner

  1. Data suggest that introduction of cGMP-specific (zeige PDE6A Proteine) residues using site-directed mutagenesis reduces selectivity of cyclic nucleotide-binding domain (CNBD) of PRKAR1A; combination of two mutations (G316R/A336T) results in a cGMP-selective binding site in the C-terminal CNBD; introduction of corresponding mutations (T192R/A212T) into the N-terminal CNBD results in a highly cGMP-selective binding site.

  2. Data show that ELOVL7, SOCS3 (zeige SOCS3 Proteine), ACSL4 (zeige ACSL4 Proteine) and CLU (zeige CLU Proteine) were upregulated while PRKAR1A and ABCG1 (zeige ABCG1 Proteine) were downregulated in the phlegm-dampness group.

  3. Electrostatic interactions are mediators in the allosteric activation of protein kinase A RIalpha.

  4. the present study reported for the first time an intronic splice site mutation in the PRKAR1A gene of a Chinese family with Carney complex, which probably caused skin pigmentation observed in affected family members.

  5. This study reports a novel point mutation of the PRKAR1A gene in a patient with Carney complex who presented with significant osteoporosis and fractures.

  6. Letter/Case Report: novel PRKAR1A mutation resulting in a splicing variant in a case of Carney complex.

  7. P-Rex1 contributes to the spatiotemporal localization of type I PKA, which tightly regulates this guanine exchange factor by a multistep mechanism.

  8. In the absence of a PRKAR1A gene mutation, our Cushing's syndrome patients do not fit the criteria for Carney's complex

  9. Case Report: although there was no family history of any of the Carney complex features and no mutations in the PRKAR1A gene were found, findings lead to the diagnosis of sporadic Carney complex.

  10. this study evaluated the functional characteristics of PRKAR1A regulatory subunits carrying eight different mutations identified in patients with acrodysostosis and compared the results with those obtained for the two alternative mutations involved in the Carney complex

Pig (Porcine) Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1) (PRKAR1A) Interaktionspartner

  1. ceramide activates plasma membrane Ca2+-ATPase from kidney-promixal tubule cells with protein kinase A as an intermediate

Cow (Bovine) Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1) (PRKAR1A) Interaktionspartner

  1. Data suggest that enzyme activation by cAMP involves highly stable conformation of Prkar1a as it binds to Prkaca; glycine residue, G235, appears to function as hinge in B/C helix conserved in Prkar1a; this "Flipback" conformation plays role in cAMP association to A domain of Prkar1a. (Prkar1a = cyclic AMP-dependent protein kinase RIalpha subunit; Prkaca = cyclic AMP-dependent protein kinase catalytic subunit)

  2. Data suggest PRKAR1A contains two structurally homologous cAMP-binding domains that exhibit marked differences in dynamic profiles in activation/inhibition of Prkaca (zeige PRKACA Proteine); conservation of structure does not necessarily imply conservation of dynamics.

  3. Results describe the structures of the protein kinase A RIalpha subunit D/D domain alone and in complex with D-AKAP2 (zeige AKAP10 Proteine).

  4. Data show that RSK1 (zeige RPS6KA1 Proteine) regulates PKAc activity in a cAMP-independent manner, and PKARIalpha by associating with RSK1 (zeige RPS6KA1 Proteine) regulates its activation and its biological functions.

  5. angle X-ray scattering studies indicate RIalpha, RIIalpha, and RIIbeta (zeige PRKAR2B Proteine) homodimers differ markedly in overall shape despite extensive sequence homology and similar molecular masses;cAMP binding does not cause large conformational changes(Prkar1a, Prkar2a (zeige PRKAR2A Proteine))

  6. the PKA RIalpha subunit dynamic C helix mediates isoform-specific domain reorganization upon C subunit binding

Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1) (PRKAR1A) Protein Überblick

Protein Überblick

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed.

Alternative names and synonyms associated with Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1) (PRKAR1A)

  • protein kinase, cAMP-dependent, regulatory, type I, alpha (PRKAR1A)
  • protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) a (prkar1aa)
  • similar to cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue-specific extinguisher 1) (TSE1) (PRKAR1A)
  • protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) (PRKAR1A)
  • protein kinase, cAMP dependent regulatory, type I, alpha (Prkar1a)
  • protein kinase, cAMP-dependent, regulatory, type I, alpha (Prkar1a)
  • 1300018C22Rik Protein
  • ACRDYS1 Protein
  • ADOHR Protein
  • CAR Protein
  • CNC Protein
  • CNC1 Protein
  • im:7047729 Protein
  • PKR1 Protein
  • PPNAD1 Protein
  • PRKAR1 Protein
  • prkar1a Protein
  • RIalpha Protein
  • RIIA Protein
  • Tse-1 Protein
  • TSE1 Protein
  • zgc:92515 Protein

Bezeichner auf Proteinebene für PRKAR1A

protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) , cAMP-dependent protein kinase type I-alpha regulatory subunit , cAMP-dependent protein kinase regulatory subunit alpha 1 , cAMP-dependent protein kinase type I-alpha regulatory subunit-like , protein kinase, cAMP dependent regulatory, type 1, alpha , cAMP-dependent protein kinase regulatory subunit RIalpha , cAMP-dependent protein kinase type I-alpha regulatory chain , protein kinase A type 1a regulatory subunit , tissue-specific extinguisher 1 , protein kinase, cAMP dependent regulatory, type I, alpha , cAMP-dependent protein kinase type I regulatory subunit , cAMP-dependent protein kinase, regulatory subunit alpha 1

GENE ID SPEZIES
454845 Pan troglodytes
480459 Canis lupus familiaris
494533 Danio rerio
707275 Macaca mulatta
719009 Macaca mulatta
100216463 Ovis aries
100395681 Callithrix jacchus
100588658 Nomascus leucogenys
19084 Mus musculus
5573 Homo sapiens
25725 Rattus norvegicus
397091 Sus scrofa
100171685 Pongo abelii
615074 Bos taurus
417438 Gallus gallus
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