anti-Patched 2 (PTCH2) Antikörper

Bezeichnung:
anti-Patched 2 Antikörper (PTCH2)
Auf www.antikoerper-online.de finden Sie aktuell 29 Patched 2 (PTCH2) Antikörper von 13 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Patched 2 Proteine (10) und und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 43 Patched 2 Produkte verfügbar.
Synonyme:
lep, patched-2, ptc-2, ptc1, PTC2, Ptch1, ptch2, xptc-2, xptch-2
Alle Antikörper anzeigen Gen GeneID UniProt
PTCH2 366452  
PTCH2 8643 Q9Y6C5
PTCH2 19207 O35595

Alle Spezies anzeigen

Weitere Synonyme anzeigen

Meistgesuchte Reaktivitäten zu anti-Patched 2 (PTCH2) Antikörper

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anti-Rat (Rattus) Patched 2 Antikörper:

anti-Human Patched 2 Antikörper:

anti-Mouse (Murine) Patched 2 Antikörper:

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Am meisten referenzierte anti-Patched 2 Antikörper

  1. Cow (Bovine) Polyclonal Patched 2 Primary Antibody für WB - ABIN2782247 : Gregory, Barlow, McLay, Kaul, Swarbreck, Dunham, Scott, Howe, Woodfine, Spencer, Jones, Gillson, Searle, Zhou, Kokocinski, McDonald, Evans, Phillips, Atkinson, Cooper, Jones, Hall, Andrews, Lloyd et al.: The DNA sequence and biological annotation of human chromosome 1. ... in Nature 2006 (PubMed)

Weitere Antikörper gegen Patched 2 Interaktionspartner

Xenopus laevis Patched 2 (PTCH2) Interaktionspartner

  1. Zyxin (zeige ZYX Antikörper) binding to Ptc2 is due to the interaction of Zyxin (zeige ZYX Antikörper) 2nd LIM (zeige PDLIM5 Antikörper)-domain (530-590 aa) with the under-membrane region of the cytoplasmic C-terminus of Ptc2 (1159-1412 aa).

Zebrafish Patched 2 (PTCH2) Interaktionspartner

  1. The Hedgehog (zeige SHH Antikörper) co-receptors patched1 (zeige PTCH1 Antikörper) and patched2 are expressed in regions of the perichondrium that will form bone before the onset of ossification.

  2. The generation and characterization of the ptc1 (zeige PTCH1 Antikörper);ptc2 double mutant assigned novel and unexpected functions to the Hh signaling pathway.

Human Patched 2 (PTCH2) Interaktionspartner

  1. Frameshift mutation in the PTCH2 gene can cause nevoid basal cell carcinoma syndrome.

  2. PTCH2 isoforms have distinct roles in Hedgehog (zeige SHH Antikörper) signalling.

  3. PTCH2 (2157G-->A), a novel missense mutation, underlies NBCCS (zeige PTCH1 Antikörper), resulting in the loss of PTCH2 inhibitory function in the Shh (zeige SHH Antikörper) signalling pathway.

  4. A susceptibility locus on 1p32-1p34 for congenital macrostomia in a Chinese family and identification of a novel PTCH2 mutation are reported.

Mouse (Murine) Patched 2 (PTCH2) Interaktionspartner

  1. Ptch2(-/-) niche cells show hyperactive noncanonical HH signaling, resulting in reduced production of essential HSC (zeige FUT1 Antikörper) regulators (Scf (zeige KITLG Antikörper), Cxcl12 (zeige CXCL12 Antikörper), and Jag1 (zeige JAG1 Antikörper)) and depletion of osteoblasts.

  2. Ptch2 is a functional Shh (zeige SHH Antikörper) receptor that shares overlapping functions with Ptch1 (zeige PTCH1 Antikörper) in Smo regulation and limb development.

  3. Ptch1 (zeige PTCH1 Antikörper)(-/-);Ptch2(-/-) cells cannot further activate the Shh (zeige SHH Antikörper) response, demonstrating that Ptch2 mediates the response to Shh (zeige SHH Antikörper) in the absence of Ptch1 (zeige PTCH1 Antikörper).

  4. Our studies indicate that concomitant loss of Ptch1 (zeige PTCH1 Antikörper) and Ptch2 activity inhibits epidermal lineage specification and differentiation.

  5. PTCH2 is a direct transcriptional target that antagonizes hedgehog (zeige SHH Antikörper) signaling in NIH/3T3 cells.

  6. Single-strand conformation polymorphism analysis was used to map mouse Ptch2 to chromosome 4 between the microsatellite markers D4Mit20 and D4Mit334.

  7. Functional compensation by Ptc1 (zeige PTCH1 Antikörper) might account for the lack of a strong mutant phenotype in Ptc2-deficient mice. Normal Ptc2 function is required for adult skin homeostasis.

Patched 2 (PTCH2) Antigen-Profil

Beschreibung des Gens

This gene encodes a transmembrane receptor of the patched gene family. The encoded protein may function as a tumor suppressor in the hedgehog signaling pathway. Alterations in this gene have been associated with nevoid basal cell carcinoma syndrome, basal cell carcinoma, medulloblastoma, and susceptibility to congenital macrostomia. Alternatively spliced transcript variants have been described.

Alternative names and synonyms associated with Patched 2 (PTCH2)

  • patched homolog 2 (Drosophila) (Ptch2) Antikörper
  • patched 2 (ptch2-b) Antikörper
  • patched 2 (ptch2-a) Antikörper
  • patched 1 (ptch1) Antikörper
  • patched 2 (PTCH2) Antikörper
  • patched homolog 2 (Ptch2) Antikörper
  • lep Antikörper
  • patched-2 Antikörper
  • ptc-2 Antikörper
  • ptc1 Antikörper
  • PTC2 Antikörper
  • Ptch1 Antikörper
  • ptch2 Antikörper
  • xptc-2 Antikörper
  • xptch-2 Antikörper

Bezeichner auf Proteinebene für anti-Patched 2 (PTCH2) Antikörper

patched homolog 2 , patched homolog 1 , patched-2 , xptc 2 , leprechaun , patched 2 , protein patched homolog 1 , protein patched homolog 2

GENE ID SPEZIES
366452 Rattus norvegicus
397836 Xenopus laevis
100191013 Xenopus laevis
30189 Danio rerio
8643 Homo sapiens
482519 Canis lupus familiaris
507948 Bos taurus
19207 Mus musculus
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