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Two paralogs of mammalian wisp1 genes were found in zebrafish.
There is a relationship between WISP1 and the metabolic parameters of gestational diabetes (GDM). And, WISP1 might be involved in the pathophysiology of GDM.
Macrophage-derived IL-10 (zeige IL10 ELISA Kits) has a role in mediating mucosal repair by epithelial WISP-1 signaling
results demonstrate that a joint effect of WISP1 rs2929970 with smoking as well as WISP1 rs16893344 with betel nut chewing causally contributes to the occurrence of OSCC. WISP1 polymorphism may serve as a marker or a therapeutic target in OSCC
Taken together, our findings presented the first evidence that Wnt1-inducible signaling pathway protein-1 was upregulated in gastric cancer and acted as an oncogene (zeige RAB1A ELISA Kits) by promoting proliferation, migration, and invasion in gastric cancer cells.
findings reveal that WISP-1 enhances VEGF-A (zeige VEGFA ELISA Kits) expression and angiogenesis through the FAK (zeige PTK2 ELISA Kits)/JNK (zeige MAPK8 ELISA Kits)/HIF-1alpha (zeige HIF1A ELISA Kits) signaling pathways, as well as via down-regulation of miR (zeige MLXIP ELISA Kits)-381 expression.
Akt (zeige AKT1 ELISA Kits) signaling pathway mediates WISP1-induced migration and proliferation of human VSMCs
WISP1 is increased in IBD and contributes to the proinflammatory cascades in the gut (zeige GUSB ELISA Kits).
Data show that WNT1-inducible signaling pathway protein-1 (WISP)-1/CCN4 expression was correlated with vascular endothelial growth factor-C (VEGF-C (zeige VEGFC ELISA Kits)) expression in Oral squamous cell carcinoma (OSCC) specimens.
WISP1-induced IL-6 (zeige IL6 ELISA Kits) expression contributes to the pro-proliferative effect on fibroblasts.
WISP1 plays an important role in regulating proliferation and apoptosis of Jurkat cells.
Upregulation of Wnt2 (zeige WNT2 ELISA Kits) expression enhanced WISP-1 and promoted vascular smooth muscle cell migration and intimal thickening.
One of the most striking new findings was up-regulation of mRNA for the matricellular protein WNT1-inducible signaling pathway protein 1 (CCN4) in metastatic cells; increased protein expression was verified by immunoblotting and immunocytochemistr
WISP1 might contribute to hepatic ischemia reperfusion injury in mice and possibly depends on TLR4 (zeige TLR4 ELISA Kits)/TRIF (zeige RNF138 ELISA Kits) signaling.
CCN4 has a positive influence on chondrogenic differentiation by modulating the effects of TGF-beta3 (zeige TGFB3 ELISA Kits).
the Bmp3 (zeige BMP3 ELISA Kits)/Wisp1 signaling pathway play a key role in mesenchymal stem cell proliferation, and consequently adipogenesis.
the Wisp1-integrin beta6 pathway is inhibited by RGD peptides in septic mice, which protects against acute lung injury
WISP1 is a novel regulator of bone turnover and Wnt (zeige WNT2 ELISA Kits) signaling
The data suggest that WISP1 may play a role in linking obesity to inflammation and insulin (zeige INS ELISA Kits) resistance and could be a novel therapeutic target for obesity.
Wnt5a (zeige WNT5A ELISA Kits)-induced Wnt1 (zeige WNT1 ELISA Kits)-inducible secreted protein-1 suppresses vascular smooth muscle cell apoptosis induced by oxidative stress.
Notch1 (zeige NOTCH1 ELISA Kits)-induced WISP-1 expression appeared to be Wnt11 (zeige WNT11 ELISA Kits)-dependent, but Wnt1 (zeige WNT1 ELISA Kits)-independent
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified.
WNT1 inducible signaling pathway protein 1
, CCN family member 4
, WNT1 induced secreted protein 1
, WNT1-inducible-signaling pathway protein 1
, Wnt-1 inducible signaling pathway protein 1
, Wnt-1-induced secreted protein