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anti-Human BRD4 Antikörper:
anti-Mouse (Murine) BRD4 Antikörper:
anti-Rat (Rattus) BRD4 Antikörper:
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Human Polyclonal BRD4 Primary Antibody für ICC, IF - ABIN438710
Rahman, Sowa, Ottinger, Smith, Shi, Harper, Howley: The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3. in Molecular and cellular biology 2011
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Human Polyclonal BRD4 Primary Antibody für ICC, IF - ABIN4285227
Zuber, Shi, Wang, Rappaport, Herrmann, Sison, Magoon, Qi, Blatt, Wunderlich, Taylor, Johns, Chicas, Mulloy, Kogan, Brown, Valent, Bradner, Lowe, Vakoc: RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. in Nature 2011
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Human Polyclonal BRD4 Primary Antibody für ChIP, WB - ABIN2668492
Flajollet, Rachez, Ploton, Schulz, Gallais, Métivier, Pawlak, Leray, Issulahi, Héliot, Staels, Salbert, Lefebvre: The elongation complex components BRD4 and MLLT3/AF9 are transcriptional coactivators of nuclear retinoid receptors. in PLoS ONE 2013
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Brd4 associates with mitotic chromosomes throughout early zebrafish embryogenesis
Together, dual inhibition of BRD4 and PI3K (zeige PIK3CA Antikörper) by SF2523 suppresses human prostate cancer cell growth in vitro and in vivo.
peroxisome proliferator activated receptor alpha peroxisome proliferator-activated receptor alpha (zeige PPARA Antikörper) PPAR-alpha (zeige PPARA Antikörper) nuclear receptor subfamily 1 group C member 1 (zeige PPARA Antikörper) peroxisome proliferative activated receptor alpha (zeige PPARA Antikörper) peroxisome proliferator-activated nuclear receptor alpha variant 3 (zeige PPARA Antikörper)
Brd4 is involved in different steps of the papillomavirus life cycle. (Review)
BRD4 and MYC (zeige MYC Antikörper) are essential for the expression of a subgroup of genes induced by class-I HDAC (zeige HDAC3 Antikörper) inhibitors.
Data show that BRD4 controls RUNX2 (zeige RUNX2 Antikörper) by binding to the enhancers (ENHs) and each RUNX2 (zeige RUNX2 Antikörper) ENH (zeige PDLIM5 Antikörper) is potentially controlled by a distinct set of TFs and c-JUN (zeige JUN Antikörper) as the principal pivot of this regulatory platform.
any of the molecules or processes in the network could be targeted to curb the oncogenic effects of c-Myc (zeige MYC Antikörper), just as BRD4 can be targeted. And since the targeting of metabolic enzymes has proved effective in mouse tumor models, it might be possible to develop new therapies based on the fact that c-Myc (zeige MYC Antikörper) has a role in controlling cellular metabolism
Brd4 inhibition attenuates unilateral ureteral obstruction-induced fibrosis by blocking TGF-beta (zeige TGFB1 Antikörper)-mediated Nox4 (zeige NOX4 Antikörper) expression.
The response of the kinome to targeted BETi treatment in a panel of BRD4-dependent ovarian carcinoma (OC) cell lines.
A miR (zeige MLXIP Antikörper)-9 mimic represses stimulus-dependent targeting of BRD4.
BRD4 and CDK9 (zeige CDK9 Antikörper) have independent, coordinated roles in promoting the myofibroblast transition
Using compound selectivity engineering and CRISPR/Cas9 genome editing, distinct functions for Erk5 (zeige MAPK7 Antikörper) and Brd4 in pluripotency regulation of mouse embryonic stem cells have been revealed.
Long-term treatment with bromodomain-containing protein 4 (BRD4) inhibitors caused telomere shortening in both mouse and human cells, suggesting BRD4 plays a role in telomere maintenance in vivo.
Fmr1 (zeige FMR1 Antikörper) knockout (KO) mice show widespread changes in histone marks as well as transcriptional misregulation resulting in increased expression of many critical synaptic genes. Data suggest that one chromatin target of FMRP (zeige FMR1 Antikörper), the reader protein Brd4, appears to be significantly involved in this transcriptional disruption.
The functional domains of mouse BRD4 and its role in transcription are described. Review.
Brd2 (zeige BRD2 Antikörper) and Brd4 genetic transcription required for Th17 cell development and adaptive immunity.
These data provide a detailed mechanism for how activated NF-kappaB (zeige NFKB1 Antikörper) and BRD4 control epithelial-mesenchymal transition initiation and transcriptional elongation in model airway epithelial cells in vitro and in a murine pulmonary fibrosis model in vivo.
DOT1L (zeige DOT1L Antikörper), via dimethylated histone H3 (zeige HIST3H3 Antikörper) K79, facilitates histone H4 (zeige HIST1H4H Antikörper) acetylation, which in turn regulates the binding of BRD4 to chromatin in acute lymphoblastic leukemia.
Acute induction of genes related to lipid accumulation in the livers of mice force-fed with fructose is associated with the induction of histone acetylation and BRD4 binding around these genes
Both mouse and human BRD4 have intrinsic histone acetyltransferase (zeige HAT Antikörper) activity.
the interaction between BRD4 and Mediator has functional importance for gene-specific transcriptional activation and for acute myeloid leukemia (zeige BCL11A Antikörper) maintenance.
The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15\;19)(q13\;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described.
Bromodomain-containing protein 4B
, bromodomain-containing protein 4B
, bromodomain containing 4
, bromodomain-containing protein 4
, bromodomain 4
, bromodomain-containing protein 4-like
, bromodomain containing protein 4
, bromodomain-containing 4
, chromosome-associated protein
, bromodomain-containing 5
, fsh-like protein
, mitotic chromosome-associated protein