RAD17 Antikörper (Middle Region)
-
- Target Alle RAD17 Antikörper anzeigen
- RAD17
-
Bindungsspezifität
- AA 225-254, Middle Region
-
Reaktivität
- Human
-
Wirt
- Kaninchen
-
Klonalität
- Polyklonal
-
Konjugat
- Dieser RAD17 Antikörper ist unkonjugiert
-
Applikation
- Western Blotting (WB), Flow Cytometry (FACS), Enzyme Immunoassay (EIA)
- Spezifität
- This antibody recognizes Human RAD17 (Center).
- Aufreinigung
- Affinity Chromatography on Protein A
- Immunogen
- KLH conjugated synthetic peptide between 225-254 amino acids from the Central region of Human RAD17
- Isotyp
- Ig Fraction
- Top Product
- Discover our top product RAD17 Primärantikörper
-
-
- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Liquid
- Konzentration
- 0.25 mg/mL
- Buffer
- PBS, 0.09 % Sodium Azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freezing and thawing.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
-
- Target
- RAD17
- Andere Bezeichnung
- RAD17 (RAD17 Produkte)
- Synonyme
- zgc:91969 antikoerper, RAD17 antikoerper, K2A18.21 antikoerper, K2A18_21 antikoerper, RADIATION SENSITIVE 17 antikoerper, CCYC antikoerper, HRAD17 antikoerper, R24L antikoerper, RAD17SP antikoerper, RAD24 antikoerper, 9430035O09Rik antikoerper, MmRad24 antikoerper, RAD17 checkpoint clamp loader component antikoerper, Rad17p antikoerper, RADIATION SENSITIVE 17 antikoerper, RAD17 antikoerper, rad17 antikoerper, ATRAD17 antikoerper, Rad17 antikoerper
- Hintergrund
- The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Eight alternatively spliced transcript variants of this gene, which encode four distinct proteins, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified.Synonyms: Cell cycle checkpoint protein RAD17, R24L, RF-C/activator 1 homolog
- Molekulargewicht
- 77055 Da
- Gen-ID
- 5884
- NCBI Accession
- NP_002864
-