HYAL1 Antikörper (Hyaluronidase-1) (AA 279-309)

Details for Product anti-HYAL1 Antibody No. ABIN952807, Anbieter: Anmelden zum Anzeigen
Antigen
  • HYAL-1
  • LUCA1
  • NAT6
  • Hya1
  • Hyal-1
  • hyaluronoglucosaminidase 1
  • HYAL1
  • Hyal1
Epitop
AA 279-309, C-Term
20
15
14
8
7
6
5
5
4
4
3
2
2
2
2
2
1
1
1
1
1
Reaktivität
Human
75
38
26
6
4
4
3
3
2
2
1
1
1
Wirt
Kaninchen
82
21
8
Klonalität
Polyklonal
Konjugat
Dieser HYAL1 Antikörper ist unkonjugiert
8
8
5
4
4
4
1
1
1
1
1
1
1
1
1
1
1
Applikation
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
70
51
38
16
13
7
6
3
3
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen KLH conjugated synthetic peptide between 279-309 amino acids from the C-terminal region of Human HYAL1 / Hyaluronidase-1
Isotyp Ig
Spezifität This antibody recognizes Human HYAL1 / Hyaluronidase-1 (C-term).
Reinigung Protein A column, followed by peptide affinity purification
Andere Bezeichnung HYAL1 / Hyaluronidase-1 (HYAL1 Antibody Abstract)
Hintergrund This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene.Synonyms: Hyal-1, Hyaluronoglucosaminidase-1, LUCA1, Lung carcinoma protein 1
Molekulargewicht 48368 Da
Gen-ID 3373
NCBI Accession NP_695013
Pathways Glycosaminoglycan Metabolic Process
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Bilder des Herstellers
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Hyaluronidase-1 (HYAL1) (AA 279-309), (C-Term) antibody (ABIN952807) Immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tis...
Western Blotting (WB) image for anti-Hyaluronidase-1 (HYAL1) (AA 279-309), (C-Term) antibody (ABIN952807) Western blot analysis of HYAL1 / Hyaluronidase-1 Antibody (C-term) in HepG2 cell line...
Allgemeine Veröffentlichungen Lanktree, Johansen, Anand, Davis, Miller, Yusuf, Hegele, ,: "Genetic variation in hyaluronan metabolism loci is associated with plasma plasminogen activator inhibitor-1 concentration." in: Blood, Vol. 116, Issue 12, pp. 2160-3, 2010 (PubMed).

Gasingirwa, Thirion, Mertens-Strijthagen, Wattiaux-De Coninck, Flamion, Wattiaux, Jadot: "Endocytosis of hyaluronidase-1 by the liver." in: The Biochemical journal, Vol. 430, Issue 2, pp. 305-13, 2010 (PubMed).

Tzuman, Sapoznik, Granot, Nevo, Neeman: "Peritoneal adhesion and angiogenesis in ovarian carcinoma are inversely regulated by hyaluronan: the role of gonadotropins." in: Neoplasia (New York, N.Y.), Vol. 12, Issue 1, pp. 51-60, 2010 (PubMed).

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