MGC83751 antikoerper, piasx antikoerper, wu:fi05f09 antikoerper, PIAS2 antikoerper, 6330408K17Rik antikoerper, AI462206 antikoerper, ARIP3 antikoerper, AU018068 antikoerper, Dib antikoerper, Miz1 antikoerper, PIASxalpha antikoerper, PIASxb antikoerper, PIASxbeta antikoerper, SIZ2 antikoerper, DIP antikoerper, MIZ antikoerper, MIZ1 antikoerper, PIASX antikoerper, PIASX-ALPHA antikoerper, PIASX-BETA antikoerper, ZMIZ4 antikoerper, protein inhibitor of activated STAT 2 L homeolog antikoerper, protein inhibitor of activated STAT 2 antikoerper, protein inhibitor of activated STAT, 2 antikoerper, pias2.L antikoerper, PIAS2 antikoerper, pias2 antikoerper, Pias2 antikoerper
Hintergrund
The PIAS (protein inhibitor of activated STAT) proteins play a crucial role as transcriptional coregulators in various cellular pathways, including the STAT, p53 and the steroid hormone signaling pathway. The PIAS protein family includes at least five evolutionarily conserved genes, including PIAS2. The major function of the PIAS proteins is the control of gene transcription and can also act as small ubiquitin-like-modifier (SUMO) E3 ligases. PIAS2 binds specifically to STAT4 following IL-12 stimulation and inhibits STAT4-mediated gene activation in human T cells. PIAS2 is a potent transcriptional activator of Bcl-2, but together with Bcl-6 can suppress the expression of Bcl-2.Synonyms: ARIP3, Androgen receptor-interacting protein 3, DAB2-interacting protein, DIP, E3 SUMO-protein ligase PIAS2, Miz1, Msx-interacting zinc finger protein, PIAS-NY protein, PIASX, Protein inhibitor of activated STAT x, Protein inhibitor of activated STAT2