Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)
Aufreinigung
This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This TNFSF15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 148-175 amino acids from the Central region of human TNFSF15.
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. An additional isoform encoded by an alternatively spliced transcript variant has been reported but the sequence of this transcript has not been determined. [provided by RefSeq].