IDH1 Antikörper (Isocitrate Dehydrogenase 1 (NADP+), Soluble) (AA 63-90)

Details for Product anti-IDH1 Antibody No. ABIN391659, Anbieter: Anmelden zum Anzeigen
Antigen
  • IDCD
  • IDH
  • IDP
  • IDPC
  • PICD
  • AI314845
  • AI788952
  • E030024J03Rik
  • Id-1
  • Idh-1
  • Idpc
  • cb876
  • fm90e09
  • im:7143416
  • wu:fm90e09
  • NADP-CICDH
  • isocitrate dehydrogenase (NADP(+)) 1, cytosolic
  • isocitrate dehydrogenase 1 (NADP+), soluble
  • isocitrate dehydrogenase 1 (NADP+) L homeolog
  • parathyroid hormone 2 receptor
  • isocitrate dehydrogenase (NADP(+)) 2, mitochondrial
  • IDH1
  • Idh1
  • idh1.L
  • idh1
  • PTH2R
  • IDH2
Epitop
AA 63-90, N-Term
27
18
12
6
6
6
5
4
4
4
4
3
3
3
2
2
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus
179
96
63
14
10
8
6
6
5
5
5
5
3
2
1
1
1
Wirt
Kaninchen
111
61
35
2
Klonalität (Klon)
Polyklonal ()
Konjugat
Dieser IDH1 Antikörper ist unkonjugiert
11
10
7
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
171
84
55
51
37
29
17
13
11
5
4
2
2
2
1
1
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen This IDH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-90 AA from the N-terminal region of human IDH1.
Klon RB18237
Isotyp Ig
Spezifität This IDH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 69~99 amino acids from the N-terminal region of human IDH1.
Homologie Cow (Bovine),Rat (Rattus)
Reinigung This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Andere Bezeichnung IDH1 (IDH1 Antibody Abstract)
Hintergrund IDH1 belongs to two distinct subclasses. The protein is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. This protein contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production.
Synonyms: Isocitrate dehydrogenase [NADP] cytoplasmic, IDH, Cytosolic NADP-isocitrate dehydrogenase, Oxalosuccinate decarboxylase, NADP(+)-specific ICDH, IDP , PICD, name: IDH1
Molekulargewicht 46659 DA
Gen-ID 3417
UniProt O75874
Forschungsgebiet Metabolism, Cell Structure
Applikationshinweise IF = 1:10-50, WB = 1:1000, IHC (p) = 1:50-100, FACS = 1:10-50
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Haltbarkeit 6 months
Bilder des Herstellers
Western Blotting (WB) image for anti-Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) (AA 63-90), (N-Term) antibody (ABIN391659) Western blot analysis of IDH1 Antibody (N-term) (ABIN391659) in mouse liver tissue an...
Immunohistochemistry (IHC) image for anti-Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) (AA 63-90), (N-Term) antibody (ABIN391659) Formalin-fixed and paraffin-embedded human brain reacted with IDH1 Antibody (N-term),...
Flow Cytometry (FACS) image for anti-Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) (AA 63-90), (N-Term) antibody (ABIN391659) Flow cytometric analysis of 293 cells using IDH1 Antibody (N-term)(bottom histogram) ...
Allgemeine Veröffentlichungen Xu, Zhao, Xu, Peng, Huang, Arnold, Ding: "Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity." in: The Journal of biological chemistry, Vol. 279, Issue 32, pp. 33946-57, 2004 (PubMed).

Geisbrecht, Gould: "The human PICD gene encodes a cytoplasmic and peroxisomal NADP(+)-dependent isocitrate dehydrogenase." in: The Journal of biological chemistry, Vol. 274, Issue 43, pp. 30527-33, 1999 (PubMed).

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