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CREB1 Antikörper (pSer133)

CREB1 Reaktivität: Human, Maus, Ratte, Zebrafisch (Danio rerio), Rind (Kuh), Huhn, Schaf, Hund, Xenopus laevis, Non-Human Primate WB, IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN372604
  • Target Alle CREB1 Antikörper anzeigen
    CREB1 (cAMP Responsive Element Binding Protein 1 (CREB1))
    Bindungsspezifität
    • 66
    • 29
    • 20
    • 17
    • 16
    • 16
    • 10
    • 8
    • 8
    • 8
    • 8
    • 7
    • 7
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer133
    Reaktivität
    • 291
    • 213
    • 179
    • 33
    • 23
    • 17
    • 16
    • 13
    • 11
    • 10
    • 9
    • 8
    • 7
    • 5
    • 3
    • 3
    • 1
    • 1
    • 1
    Human, Maus, Ratte, Zebrafisch (Danio rerio), Rind (Kuh), Huhn, Schaf, Hund, Xenopus laevis, Non-Human Primate
    Wirt
    • 264
    • 29
    • 1
    • 1
    Kaninchen
    Klonalität
    • 239
    • 56
    Polyklonal
    Konjugat
    • 148
    • 16
    • 14
    • 12
    • 12
    • 11
    • 11
    • 11
    • 11
    • 10
    • 10
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    Dieser CREB1 Antikörper ist unkonjugiert
    Applikation
    • 224
    • 100
    • 98
    • 74
    • 56
    • 56
    • 48
    • 47
    • 20
    • 17
    • 16
    • 6
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Spezifität
    Specific for the ~45k CREB protein phosphorylated at Ser133. Immunolabeling is blocked by lambda-phosphatase treatment.
    Kreuzreaktivität (Details)
    Species reactivity (expected):Bovine, Canine, Chicken, Human, Mouse, Sheep, Xenopus, Zebrafish and non-Human Primates.
    Species reactivity (tested):Rat.
    Aufreinigung
    Sequential Chromatography on phospho- and dephosphopeptide affinity columns.
    Immunogen
    Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser133 of rat CREB.
    Isotyp
    IgG
    Top Product
    Discover our top product CREB1 Primärantikörper
  • Applikationshinweise
    Western Blot: 1/1000.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store the antibody undiluted (in aliquots) at-20 °C.
  • Target
    CREB1 (cAMP Responsive Element Binding Protein 1 (CREB1))
    Andere Bezeichnung
    CREB1 (CREB1 Produkte)
    Synonyme
    creb antikoerper, CREB1 antikoerper, Creb1 antikoerper, CREB antikoerper, 2310001E10Rik antikoerper, 3526402H21Rik antikoerper, AV083133 antikoerper, Creb antikoerper, Creb-1 antikoerper, creb1 antikoerper, zgc:55598 antikoerper, cAMP responsive element binding protein 1 antikoerper, cAMP responsive element binding protein antikoerper, cAMP responsive element binding protein 1 S homeolog antikoerper, cAMP responsive element binding protein 1a antikoerper, CREB1 antikoerper, creb1 antikoerper, CREB antikoerper, Creb1 antikoerper, creb1.S antikoerper, creb1a antikoerper
    Hintergrund
    It is well known that the control of gene expression involves activation of protein kinase cascades that regulate transcription factors within the nucleus (Karin and Hunter, 1995). The cyclic AMP response element binding protein (CREB) is one of the best characterized stimulus-induced transcription factors (Montminy, 1997). This transcription factor is a component of intracellular signaling events that regulate a wide range of biological functions, from spermatogenesis to circadian rhythms and memory (Shaywitz and Greenberg, 1999, Silva et al., 1998). A variety of protein kinases including protein kinase A (PKA), mitogen-activated protein kinases (MAPKs), and Ca2+/calmodulin-dependent protein kinases (CaMKs) phosphorylate CREB at serine 133 (Ser133), and phosphorylation of Ser133 are required for CREB-mediated transcription (Johannessen et al., 2004, Kornhauser et al., 2002).Synonyms: CREB-1, Cyclic AMP-responsive element-binding protein 1, cAMP-responsive element-binding protein 1
    Gen-ID
    81646
    NCBI Accession
    NP_112279
    UniProt
    P15337
    Pathways
    TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Thyroid Hormone Synthesis, Activation of Innate immune Response, Myometrial Relaxation and Contraction, Regulation of Cell Size, Toll-Like Receptors Cascades, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Positive Regulation of fat Cell Differentiation
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