The antibody detects endogenous level of total IGF-1R protein.
Aufreinigung
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Immunogen
Peptide sequence around AA 1163-1167, 1164-1168 (T-D-Y-Y-R-K) derived from Human IGF-1R . Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
IGF1R
Reaktivität: Human
WB
Wirt: Kaninchen
Polyclonal
unconjugated
Applikationshinweise
Western blotting: 1:500-1:1000
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Konzentration
1 mg/mL
Buffer
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C/-20 °C
Informationen zur Lagerung
Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Haghir, Rezaee, Nomani, Sankian, Kheradmand, Hami: "Sexual dimorphism in expression of insulin and insulin-like growth factor-I receptors in developing rat cerebellum." in: Cellular and molecular neurobiology, Vol. 33, Issue 3, pp. 369-77, (2013) (PubMed).
Han, Quirion, Zheng: "WITHDRAWN: Glutamate Attenuates IGF-1 Receptor Signaling via NR2B containing NMDA Receptors 3 and neuronal Nitric Oxide Synthase." in: Biochemical and biophysical research communications, (2011) (PubMed).
This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1.