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TRPV1 Antikörper (4th Cytoplasmic Loop)

TRPV1 Reaktivität: Human, Meerschweinchen WB, IHC Wirt: Schaf Polyclonal unconjugated
Produktnummer ABIN351248
  • Target Alle TRPV1 Antikörper anzeigen
    TRPV1 (Transient Receptor Potential Cation Channel, Subfamily V, Member 1 (TRPV1))
    Bindungsspezifität
    • 8
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    4th Cytoplasmic Loop
    Reaktivität
    • 37
    • 28
    • 24
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Meerschweinchen
    Wirt
    • 53
    • 6
    • 2
    • 1
    Schaf
    Klonalität
    • 57
    • 5
    Polyklonal
    Konjugat
    • 39
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Dieser TRPV1 Antikörper ist unkonjugiert
    Applikation
    • 31
    • 23
    • 13
    • 7
    • 7
    • 6
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Spezifität
    Specific for TRPV1.
    Immunogen
    A synthetic peptide the 4th cytoplasmic loop of human TRPV1 (VR1, capsaicin receptor, vanilloid receptor 1) conjugated to immunogenic carrier protein was used as the antigen. The antigen is homologous in guinea pig.
    Isotyp
    IgG
    Top Product
    Discover our top product TRPV1 Primärantikörper
  • Applikationshinweise
    A concentration of 10-50 µg/ml is recommended.
    The optimal concentration should be determined by the end user.
    Not yet tested in other applications.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
    Handhabung
    Avoid freeze and thaw cycles.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
    Haltbarkeit
    12 months
  • Target
    TRPV1 (Transient Receptor Potential Cation Channel, Subfamily V, Member 1 (TRPV1))
    Andere Bezeichnung
    TRPV1 (TRPV1 Produkte)
    Synonyme
    si:dkey-9e15.2 antikoerper, VR.5'sv antikoerper, Vr1 antikoerper, Vr1l1 antikoerper, VR1 antikoerper, OTRPC1 antikoerper, TRPV1alpha antikoerper, TRPV1beta antikoerper, VR-1 antikoerper, transient receptor potential cation channel, subfamily V, member 1 antikoerper, transient receptor potential cation channel subfamily V member 1 antikoerper, trpv1 antikoerper, Trpv1 antikoerper, TRPV1 antikoerper
    Hintergrund
    Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo.
    Function: Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Responses evoked by low pH and heat, and capsaicin can be antagonized by capsazepine. Also known as: TrpV1, osm-9-like TRP channel 1, OTRPC1, vanilloid receptor 1, capsaicin receptor, VR1, DKFZp434K0220, transient receptor potential cation channel subfamily V member 1.
    Pathways
    Dicarboxylic Acid Transport
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