NTRK3 Antikörper (Cytoplasmic Domain)
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- Target Alle NTRK3 Antikörper anzeigen
- NTRK3 (Neurotrophic tyrosine Kinase, Receptor, Type 3 (NTRK3))
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Bindungsspezifität
- AA 780-830, Cytoplasmic Domain
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser NTRK3 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC)
- Spezifität
- Specific for TrkC.
- Kreuzreaktivität
- Human, Maus, Ratte
- Kreuzreaktivität (Details)
- Other species not yet tested.
- Aufreinigung
- IgG
- Immunogen
- A synthetic peptide from AA 780-830 of the cytoplasmic domain of human TrkC conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and mouse.
- Isotyp
- IgG
- Top Product
- Discover our top product NTRK3 Primärantikörper
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- Applikationshinweise
- IHC, WB. A concentration of 10-50 μg,ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Reconstitute in 500 μL of sterile water. Centrifuge to remove any insoluble material.
- Handhabung
- Avoid freeze and thaw cycles.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- NTRK3 (Neurotrophic tyrosine Kinase, Receptor, Type 3 (NTRK3))
- Andere Bezeichnung
- TrkC (NTRK3 Produkte)
- Synonyme
- TRKC antikoerper, gp145(trkC) antikoerper, trkC antikoerper, AW125844 antikoerper, Ntrk3_tv3 antikoerper, TrkC antikoerper, neurotrophic receptor tyrosine kinase 3 antikoerper, neurotrophic tyrosine kinase, receptor, type 3 antikoerper, NTRK3 antikoerper, Ntrk3 antikoerper
- Hintergrund
- FUNCTION: Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties. CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 and ARMS. SUBCELLULAR LOCATION: Membrane, Single-pass type I membrane protein. TISSUE SPECIFICITY: Widely expressed, mainly in the nervous tissue. The isoform B is expressed in a relatively large amount in the adult brain comparatively to fetal brain.,Neurotrophic Receptors,Neurotrophic tyrosine kinase receptor type 3, TrkC tyrosine kinase, GP145-TrkC, Trk-C, NT-3 growth factor receptor, NTRK3
- UniProt
- Q16288
- Pathways
- RTK Signalweg, Neurotrophin Signalübertragung, Regulation of Cell Size
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