TMEM173 Antikörper (Transmembrane Protein 173) (Middle Region)

Details for Product anti-TMEM173 Antibody No. ABIN2783202, Anbieter: Anmelden zum Anzeigen
Antigen
  • ERIS
  • MITA
  • MPYS
  • NET23
  • STING
  • 2610307O08Rik
  • Mita
  • RGD1562552
  • transmembrane protein 173
  • TMEM173
  • Tmem173
Alternativen
anti-Human TMEM173 Antikörper für Immunofluorescence (fixed cells)
Epitop
Middle Region
18
14
10
5
5
5
5
2
2
2
2
1
1
1
1
Reaktivität
Human, Schwein
135
40
29
2
1
1
1
1
1
1
1
Wirt
Kaninchen
96
46
Klonalität
Polyklonal
Konjugat
Dieser TMEM173 Antikörper ist unkonjugiert
6
6
3
3
3
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
Applikation
Western Blotting (WB)
97
51
48
41
20
15
13
13
10
7
4
4
1
Optionen
Hersteller
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Immunogen The immunogen is a synthetic peptide directed towards the middle region of human TMEM173
Blocking Peptide Zu diesem Produkt passt das Blocking Peptide ABIN985225.
Sequenz DPNIRFLDKL PQQTGDHAGI KDRVYSNSIY ELLENGQRAG TCVLEYATPL
Homologie Human: 100%, Pig: 83%
Produktmerkmale This is a rabbit polyclonal antibody against TMEM173. It was validated on Western Blot using a cell lysate as a positive control.
Reinigung Affinity Purified
Andere Bezeichnung TMEM173 (TMEM173 Antibody Abstract)
Hintergrund TMEM173 acts as a facilitator of innate immune signaling. It is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon (IFN-alpha and IFN-beta) and exert a potent anti-viral state following expression. TMEM173 may be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons.It also may be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). TMEM173 mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.
Alias Symbols: FLJ38577, ERIS, MITA, MPYS, NET23, STING
Protein Interaction Partner: MAVS, TBK1, UBC, TRAF3, IRF3, TOMM70A, TSPAN6, TRIM32, STT3B, TMEM259, YIPF5, HM13, CLPTM1L, MBOAT7, CCDC47, SEC61A1, CNNM3, LTN1, SLC39A14, GLMN, SGPL1, SURF4, RNF5, ABCC1, STT3A, IRAK1, ACSL3, DDOST, NPC1, TMEM173, TRIM56,
Protein Size: 379
Molekulargewicht 42 kDa
Gen-ID 340061
NCBI Accession NM_198282, NP_938023
UniProt Q86WV6
Forschungsgebiet Immunology, Innate Immunity, Cytokines
Pathways Activation of Innate immune Response
Applikationshinweise Optimal working dilutions should be determined experimentally by the investigator.
Kommentare

Antigen size: 379 AA

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Bilder des Herstellers
Western Blotting (WB) image for anti-TMEM173 Antikörper (Transmembrane Protein 173) (Middle Region) (ABIN2783202) WB Suggested Anti-TMEM173 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: <...
Produkt verwendet in: Panchanathan, Liu, Xin, Choubey: "Identification of a negative feedback loop between cyclic di-GMP-induced levels of IFI16 and p202 cytosolic DNA sensors and STING." in: Innate immunity, Vol. 20, Issue 7, pp. 751-9, 2014 (PubMed).

Duan, Ponomareva, Veeranki, Panchanathan, Dickerson, Choubey: "Differential roles for the interferon-inducible IFI16 and AIM2 innate immune sensors for cytosolic DNA in cellular senescence of human fibroblasts." in: Molecular cancer research : MCR, Vol. 9, Issue 5, pp. 589-602, 2011 (PubMed).

Gerhard, Wagner, Feingold, Shenmen, Grouse, Schuler, Klein, Old, Rasooly, Good, Guyer, Peck, Derge, Lipman, Collins, Jang, Sherry, Feolo, Misquitta, Lee, Rotmistrovsky, Greenhut, Schaefer, Buetow et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ..." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).

Allgemeine Veröffentlichungen Gunnarsdóttir, Li, Bauchet, Finstermeier, Stoneking: "High-throughput sequencing of complete human mtDNA genomes from the Philippines." in: Genome research, Vol. 21, Issue 1, pp. 1-11, 2011 (PubMed).