UVRAG Antikörper (C-Term)

Produktnummer ABIN1882151

Produktdetails anti-UVRAG Antikörper

Target: UVRAG (UV Radiation Resistance Associated Gene (UVRAG))

Bindungsspezifität: AA 540-569, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UVRAG Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This UVRAG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 540-569 amino acids from the C-terminal region of human UVRAG.

Klon: RB13045

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-UVRAG Antikörper (ABIN1882151)

Wei: "Autophagic induction of amyotrophic lateral sclerosis-linked Cu/Zn superoxide dismutase 1 G93A mutant in NSC34 cells." in: Neural regeneration research, Vol. 9, Issue 1, pp. 16-24, (2014) (PubMed).

Bodemann, Orvedahl, Cheng, Ram, Ou, Formstecher, Maiti, Hazelett, Wauson, Balakireva, Camonis, Yeaman, Levine, White: "RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly." in: Cell, Vol. 144, Issue 2, pp. 253-67, (2011) (PubMed).

Liang, Feng, Ku, Dotan, Canaani, Oh, Jung: "Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG." in: Nature cell biology, Vol. 8, Issue 7, pp. 688-99, (2006) (PubMed).

Vogt, Affara, Davey, Hammer, Jobling, Lau, Mitchell, Schempp, Tyler-Smith, Williams, Yen, Rappold: "Report of the Third International Workshop on Y Chromosome Mapping 1997. Heidelberg, Germany, April 13-16, 1997." in: Cytogenetics and cell genetics, Vol. 79, Issue 1-2, pp. 1-20, (1998) (PubMed).

Details zu UVRAG

Target: UVRAG (UV Radiation Resistance Associated Gene (UVRAG))

Andere Bezeichnung: UVRAG (UVRAG Produkte)

Synonyme: DHTX antikoerper, VPS38 antikoerper, p63 antikoerper, 9530039D02Rik antikoerper, AI648770 antikoerper, BB124205 antikoerper, Uvrag1 antikoerper, Uvragl antikoerper, zgc:56164 antikoerper, uvrag antikoerper, MGC81810 antikoerper, UVRAG antikoerper, MGC131135 antikoerper, CG6116 antikoerper, Dmel\\CG6116 antikoerper, UV radiation resistance associated antikoerper, UV radiation resistance associated gene antikoerper, UV radiation resistance associated S homeolog antikoerper, UV radiation resistance associated L homeolog antikoerper, UV-resistance associated gene antikoerper, UVRAG antikoerper, Uvrag antikoerper, uvrag antikoerper, uvrag.S antikoerper, uvrag.L antikoerper

Hintergrund: UVRAG complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving the UVAG gene are associated with left-right axis malformation and mutations in the gene have been associated with colon cancer.

Molekulargewicht: 78151

NCBI Accession: NP_003360

UniProt: Q9P2Y5