NPC1 Antikörper (AA 34-174)

Produktnummer ABIN1724876

Produktdetails anti-NPC1 Antikörper

Target: NPC1 (Niemann-Pick Disease, Type C1 (NPC1))

Bindungsspezifität: AA 34-174

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser NPC1 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Aufreinigung: purified

Immunogen: Purified recombinant fragment of human NPC1 (AA: 34-174) expressed in E. coli.

Klon: 8D10B6

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: 4°C, -20°C for long term storage

Referenzen für anti-NPC1 Antikörper (ABIN1724876)

Morales, Amigo, Balboa, Acuña, Castro, Molina, Miquel, Nervi, Rigotti, Zanlungo: "Deficiency of Niemann-Pick C1 protein protects against diet-induced gallstone formation in mice." in: Liver international : official journal of the International Association for the Study of the Liver, Vol. 30, Issue 6, pp. 887-97, (2010) (PubMed).

Xu, Zhou, Xia, Xia, Chen, Duan, Luo: "Defects of synaptic vesicle turnover at excitatory and inhibitory synapses in Niemann-Pick C1-deficient neurons." in: Neuroscience, Vol. 167, Issue 3, pp. 608-20, (2010) (PubMed).

Details zu NPC1

Target: NPC1 (Niemann-Pick Disease, Type C1 (NPC1))

Andere Bezeichnung: NPC1 (NPC1 Produkte)

Synonyme: NPC antikoerper, 9130221N23Rik antikoerper, Gm243 antikoerper, Cdig2 antikoerper, im:7149020 antikoerper, wu:fb53a12 antikoerper, wu:fc29a12 antikoerper, A430089E03Rik antikoerper, C85354 antikoerper, D18Ertd139e antikoerper, D18Ertd723e antikoerper, lcsd antikoerper, nmf164 antikoerper, spm antikoerper, NPC intracellular cholesterol transporter 1 antikoerper, NPC1 like intracellular cholesterol transporter 1 antikoerper, Niemann-Pick disease, type C1 antikoerper, Niemann-Pick C1 protein antikoerper, NPC1 antikoerper, Npc1l1 antikoerper, Npc1 antikoerper, npc1 antikoerper, LOC579887 antikoerper

Hintergrund:

Description: This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments. ,

Aliases: NPC

Molekulargewicht: 142.2 kDa

Gen-ID: 4864

HGNC: 4864