NPC1 Antikörper (C-Term)

Produktnummer ABIN500383

Produktdetails anti-NPC1 Antikörper

Target: NPC1 (Niemann-Pick Disease, Type C1 (NPC1))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NPC1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Spezifität: This antibody detects NPC1. It will not cross-react to NPC2, another gene whose defects also result in Niemann-Pick type C disease.

Kreuzreaktivität (Details): Species reactivity (tested):Human

Aufreinigung: Peptide affinity chromatography

Immunogen: NPC1 antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human NPC1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot: 1 - 2 μg/mL. Imunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu NPC1

Target: NPC1 (Niemann-Pick Disease, Type C1 (NPC1))

Andere Bezeichnung: NPC1 (NPC1 Produkte)

Synonyme: NPC antikoerper, 9130221N23Rik antikoerper, Gm243 antikoerper, Cdig2 antikoerper, im:7149020 antikoerper, wu:fb53a12 antikoerper, wu:fc29a12 antikoerper, A430089E03Rik antikoerper, C85354 antikoerper, D18Ertd139e antikoerper, D18Ertd723e antikoerper, lcsd antikoerper, nmf164 antikoerper, spm antikoerper, NPC intracellular cholesterol transporter 1 antikoerper, NPC1 like intracellular cholesterol transporter 1 antikoerper, Niemann-Pick disease, type C1 antikoerper, Niemann-Pick C1 protein antikoerper, NPC1 antikoerper, Npc1l1 antikoerper, Npc1 antikoerper, npc1 antikoerper, LOC579887 antikoerper

Hintergrund: Mutations in the Niemann-Pick disease type C1 (NPC1) gene result in a fatal progressive neurodegenerative disorder characterized by an abnormal sequestration of lipids including cholesterol and glycosphingolipids. The NPC1 protein is a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. NPC1 transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. NPC1, in addition to FTO, MC4R, and PTER has recently been shown to be a new risk loci for early-onset and morbid adult obesity in European populations.Synonyms: Niemann-Pick C1 protein

Gen-ID: 4864

NCBI Accession: NP_000262

UniProt: O15118