TNFSF10 Antikörper (Tumor Necrosis Factor (Ligand) Superfamily, Member 10) (AA 95-281) (PE)

Details for Product anti-TNFSF10 Antibody No. ABIN1690743, Anbieter: Anmelden zum Anzeigen
Antigen
  • TRAIL
  • tl2
  • apo2l
  • cd253
  • trail
  • apo-2l
  • trail1
  • xtrail1
  • APO2L
  • Apo-2L
  • CD253
  • TL2
  • A330042I21Rik
  • AI448571
  • APO-2L
  • Ly81
  • Trail
  • tumor necrosis factor (ligand) superfamily, member 10
  • TNF-related apoptosis inducing ligand-like
  • TNFSF10
  • TRAIL-LIKE
  • tnfsf10
  • Tnfsf10
Epitop
AA 95-281
40
26
15
7
6
6
5
4
4
3
3
3
3
2
2
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human
321
74
34
3
3
2
1
1
1
Wirt
Maus
191
152
24
2
1
Klonalität (Klon)
Monoklonal ()
Konjugat
Dieser TNFSF10 Antikörper ist konjugiert mit PE
38
20
14
10
5
5
4
4
3
3
3
3
3
3
3
3
3
2
2
1
1
1
1
1
1
1
1
1
1
Applikation
Functional Studies (Func), Flow Cytometry (FACS)
239
117
113
53
49
27
17
14
13
13
10
8
4
2
2
2
2
2
1
1
1
1
1
Optionen
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
Anmelden zum Anzeigen
Immunogen Recombinant soluble fragment (aa 95-281) of human TRAIL.
Klon 2E5
Isotyp IgG1
Spezifität The antibody 2E5 reacts with TRAIL (APO-2L), a 21 kDa cytotoxic protein, activator of rapid apoptosis in tumor cells. TRAIL is mainly expressed in spleen, lung, prostate and also in many other tissues.
Keine Kreuzreaktivität Maus
Produktmerkmale The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
Andere Bezeichnung TNFSF10 (TNFSF10 Antibody Abstract)
Hintergrund Human CD253 / TRAIL (TNF-Related Apoptosis Inducing Ligand), also called Apo2, is a type II membrane protein from the TNF family. TRAIL is a cytotoxic protein which activates rapid apoptosis in tumor cells, but not in normal cells. TRAIL-induced apotosis, is achieved through binding to two dealth-signaling receptors, DR4 (CD261 / TRAIL-R1) and DR5 (CD262 / TRAIL-R2).
Forschungsgebiet Cancer, Apoptosis/Necrosis
Pathways Apoptose, Positive Regulation of Endopeptidase Activity
Applikationshinweise The reagent is designed for Flow Cytometry analysis.
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 0.1 mg/mL
Buffer The reagent is provided in phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2 % (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent.
Handhabung Do not freeze.
Avoid prolonged exposure to light.
Lagerung 4 °C
Informationen zur Lagerung Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.
Bilder des Herstellers
Apoptosis Detection (AD) image for anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) (AA 95-281) antibody (PE) (ABIN1690743) Induction of apoptosis Apoptosis induced in JURKAT human T cell leukemia cell line by...
Produkt verwendet in: Hyer, Croxton, Krajewska, Krajewski, Kress, Lu, Suh, Sporn, Cryns, Zapata, Reed: "Synthetic triterpenoids cooperate with tumor necrosis factor-related apoptosis-inducing ligand to induce apoptosis of breast cancer cells." in: Cancer research, Vol. 65, Issue 11, pp. 4799-808, 2005 (PubMed).

Plasilova, Zivny, Jelinek, Neuwirtova, Cermak, Necas, Andera, Stopka: "TRAIL (Apo2L) suppresses growth of primary human leukemia and myelodysplasia progenitors." in: Leukemia, Vol. 16, Issue 1, pp. 67-73, 2002 (PubMed).

Haben Sie etwas anderes gesucht?