CDK5R1 Antikörper (C-Term)

Produktnummer ABIN1537017

Produktdetails anti-CDK5R1 Antikörper

Target: CDK5R1 (Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35) (CDK5R1))

Bindungsspezifität: AA 272-301, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CDK5R1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie: B, M, Rat

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CDK5R1(p35) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 272-301 amino acids from the C-terminal region of human CDK5R1(p35).

Klon: RB36667

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Details zu CDK5R1

Target: CDK5R1 (Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35) (CDK5R1))

Andere Bezeichnung: CDK5R1(p35) (CDK5R1 Produkte)

Synonyme: CDK5P35 antikoerper, CDK5R antikoerper, NCK5A antikoerper, p23 antikoerper, p25 antikoerper, p35 antikoerper, p35nck5a antikoerper, cdk5r1 antikoerper, zgc:92814 antikoerper, CDK5R1 antikoerper, Cdk5r antikoerper, P25/P35 antikoerper, D11Bwg0379e antikoerper, Xp35.1 antikoerper, cyclin dependent kinase 5 regulatory subunit 1 antikoerper, cyclin-dependent kinase 5, regulatory subunit 1b (p35) antikoerper, cyclin-dependent kinase 5 regulatory subunit 1 antikoerper, S100 calcium binding protein A9 antikoerper, cyclin-dependent kinase 5, regulatory subunit 1 (p35) antikoerper, cyclin-dependent kinase 5, regulatory subunit 1 (p35) L homeolog antikoerper, CDK5R1 antikoerper, cdk5r1b antikoerper, Cdk5r1 antikoerper, S100A9 antikoerper, cdk5r1.L antikoerper

Substanzklasse: Viral Protein

Hintergrund: P35 is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5), the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.

Molekulargewicht: 34060

Gen-ID: 8851

NCBI Accession: NP_003876

UniProt: Q15078

Pathways: Stem Cell Maintenance, Regulation of Cell Size, Positive Regulation of Endopeptidase Activity