CDK5R1 Produkte
(Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35) (CDK5R1))
Kategorien
The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5)\; the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. [provided by RefSeq, Jul 2008].
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Ausgewählte CDK5R1 Kategorien
CDK5R1 Antikörper
High quality antibodies with extensive validation data.
CDK5R1 ELISA Kits
Reliable ELISA kits for a wide range of species.
CDK5R1 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene CDK5R1 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IHC, IF, IP, ICC, AA
Validierungen
- (4)
Kat. Nr.
ABIN2486463
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IHC, IF, IP, ICC, AA
Validierungen
- (4)
Kat. Nr.
ABIN2486459
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IHC, IF, IP, ICC, AA
Validierungen
- (4)
Kat. Nr.
ABIN2486461
Menge
100 μg
Datenblatt
Datenblatt
Empfohlene CDK5R1 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Rat
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6966171
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6966170
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validierungen
Kat. Nr.
ABIN5648251
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene CDK5R1 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7122534
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1348963
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN1686721
Menge
100 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren CDK5R1 Produkten
: "Ganetespib (STA-9090), a nongeldanamycin HSP90 inhibitor, has potent antitumor activity in in vitro and in vivo models of non-small cell lung cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 18, Issue 18, pp. 4973-85, (2012) (PubMed).: "Phosphoregulation of the RNA-binding protein Hu antigen R (HuR) by Cdk5 affects centrosome function." in: The Journal of biological chemistry, Vol. 287, Issue 38, pp. 32277-87, (2012) (PubMed).
: "CDK5 activator p35 downregulates E-cadherin precursor independently of CDK5." in: FEBS letters, Vol. 582, Issue 8, pp. 1197-202, (2008) (PubMed).
: "Expression of cyclin-dependent kinase 5 mRNA and protein in the human brain following acute ischemic stroke." in: Brain pathology (Zurich, Switzerland), Vol. 17, Issue 1, pp. 11-23, (2007) (PubMed).
: "Increased immunoreactivity of cdk5 activators in hippocampal sclerosis." in: Neuroreport, Vol. 18, Issue 5, pp. 511-6, (2007) (PubMed).
: "Stable association of hsp90 and p23, but Not hsp70, with active human telomerase." in: The Journal of biological chemistry, Vol. 276, Issue 19, pp. 15571-4, (2001) (PubMed).
: "The p23 molecular chaperones act at a late step in intracellular receptor action to differentially affect ligand efficacies." in: Genes & development, Vol. 14, Issue 4, pp. 422-34, (2000) (PubMed).
: "Molecular chaperone machines: chaperone activities of the cyclophilin Cyp-40 and the steroid aporeceptor-associated protein p23." in: Science (New York, N.Y.), Vol. 274, Issue 5293, pp. 1718-20, (1997) (PubMed).
: "Characterization of a novel 23-kilodalton protein of unactive progesterone receptor complexes." in: Molecular and cellular biology, Vol. 14, Issue 3, pp. 1956-63, (1994) (PubMed).
Synonyme und alternative Namen zu CDK5R1
cyclin dependent kinase 5 regulatory subunit 1 (CDK5R1), cyclin-dependent kinase 5, regulatory subunit 1b (p35) (cdk5r1b), cyclin-dependent kinase 5 regulatory subunit 1 (Cdk5r1), S100 calcium binding protein A9 (S100A9), cyclin-dependent kinase 5, regulatory subunit 1 (p35) (Cdk5r1), cyclin-dependent kinase 5, regulatory subunit 1 (p35) L homeolog (cdk5r1.L), cyclin dependent kinase 5 regulatory subunit 1 (Cdk5r1), CDK5P35, CDK5R, Cdk5r, cdk5r1, CDK5R1, D11Bwg0379e, NCK5A, p23, p25, P25/P35, p35, p35nck5a, Xp35.1, zgc:92814Bezeichner auf Proteinebene für CDK5R1
- CDK5 activator 1
- TPKII regulatory subunit
- cyclin-dependent kinase 5 activator 1
- cyclin-dependent kinase 5 regulatory subunit 1
- neuronal CDK5 activator
- regulatory partner for CDK5 kinase
- tau protein kinase II 23kDa subunit
- cyclin-dependent kinase 5 regulatory subunit
- cyclin-dependent kinase 5, regulatory subunit 1 (p35)
- p23
- tau protein kinase II 23 kDa subunit
- BEE22
- S100 calcium-binding protein A9
- calgranulin-B
- neutrophil cytosolic 23 kDa protein
- protein S100-A9
- cyclin-dependent kinase 5, regulatory subunit (p35) 1
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