CDK4 Produkte
(Cyclin-Dependent Kinase 4 (CDK4))
Kategorien
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008].
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Ausgewählte CDK4 Kategorien
CDK4 Antikörper
High quality antibodies with extensive validation data.
CDK4 ELISA Kits
Reliable ELISA kits for a wide range of species.
CDK4 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene CDK4 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, IF, FACS, IHC (p)
Validierungen
- (3)
- (6)
Kat. Nr.
ABIN391751
Menge
400 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IF, ICC, IHC (p)
Validierungen
- (2)
- (8)
Kat. Nr.
ABIN2855529
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
WB, IHC
Validierungen
- (6)
Kat. Nr.
ABIN6999859
Menge
20 μL
Datenblatt
Datenblatt
Empfohlene CDK4 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Rat
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6966166
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6966165
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6955156
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene CDK4 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
- (1)
Kat. Nr.
ABIN1348950
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Insect cells (Sf21)
Validierungen
- (2)
Kat. Nr.
ABIN5570456
Menge
5 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Insect cells (Sf9)
Validierungen
- (2)
Kat. Nr.
ABIN5570012
Menge
100 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren CDK4 Produkten
: "ASIC1a Inhibitor mambalgin-2 Suppresses the Growth of Leukemia Cells by Cell Cycle Arrest." in: Acta naturae, Vol. 12, Issue 2, pp. 101-116, (2020) (PubMed).: "Piperlongumine induces autophagy in biliary cancer cells via reactive oxygen species-activated Erk signaling pathway." in: International journal of molecular medicine, Vol. 44, Issue 5, pp. 1687-1696, (2020) (PubMed).
: "Regulation of miR-34b/c-targeted gene expression program by SUMOylation." in: Nucleic acids research, Vol. 46, Issue 14, pp. 7108-7123, (2019) (PubMed).
: "The receptor for activated protein kinase C promotes cell growth, invasion and migration in cervical cancer." in: International journal of oncology, Vol. 51, Issue 5, pp. 1497-1507, (2018) (PubMed).
: "SUMO2 modification of Aurora B and its impact on follicular development and atresia in the mouse ovary." in: International journal of molecular medicine, Vol. 41, Issue 6, pp. 3115-3126, (2018) (PubMed).
: "Proteins of the retinoblastoma pathway, FEN1 and MGMT are novel potential prognostic biomarkers in pancreatic adenocarcinoma." in: Pathology, research and practice, Vol. 214, Issue 6, pp. 840-847, (2018) (PubMed).
: "Immune regulation mechanism of Astragaloside IV on RAW264.7 cells through activating the NF-κB/MAPK signaling pathway." in: International immunopharmacology, Vol. 49, pp. 38-49, (2018) (PubMed).
: "miR-3619-5p inhibits prostate cancer cell growth by activating CDKN1A expression." in: Oncology reports, Vol. 37, Issue 1, pp. 241-248, (2017) (PubMed).
: "Combination of metformin and sorafenib suppresses proliferation and induces autophagy of hepatocellular carcinoma via targeting the mTOR pathway." in: International journal of oncology, Vol. 50, Issue 1, pp. 297-309, (2017) (PubMed).
: "Tsc1 deficiency impairs mammary development in mice by suppression of AKT, nuclear ERα, and cell-cycle-driving proteins." in: Scientific reports, Vol. 6, pp. 19587, (2017) (PubMed).
Synonyme und alternative Namen zu CDK4
cyclin-dependent kinase 4 (cdk4), cyclin dependent kinase 4 (CDK4), cyclin-dependent kinase 4 (Cdk4), cyclin dependent kinase 4 (Cdk4), Cyclin-dependent kinase 4 (Cdk4), cyclin-dependent kinase 4 L homeolog (cdk4.L), 8-6, cdk, CDK4, cdk4, CDK4/6, Cdk4/6, cdk4/6, CG5072, CMM3, Crk3, dCdk4, DmCdk4, Dmel\\CG5072, l(2)05428, l(2)0671, l(2)k06503, l(2)s4639, l(2)sh0671, Pk53C, Pk?7, PSK-J3, xcdk4, zgc:153726Bezeichner auf Proteinebene für CDK4
- cell division protein kinase 4
- PSK-J3
- cyclin dependent kinase 4
- p34
/cdk4 - serine/threonine kinase
- Cell division protein kinase 4
- CG5072-PA
- CG5072-PB
- CG5072-PC
- Cdk4-PA
- Cdk4-PB
- Cdk4-PC
- Cyclin-dependent kinase 4/6
- cyclin-dependent kinase 4
- protein kinase-like 53C
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