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CDK5R1 Antikörper (Atto 390)

CDK5R1 Reaktivität: Human WB, ELISA, IHC, IF, IP, ICC, AA Wirt: Maus Monoclonal JJ6 Atto 390
Produktnummer ABIN2486451
  • Target Alle CDK5R1 Antikörper anzeigen
    CDK5R1 (Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35) (CDK5R1))
    Reaktivität
    • 60
    • 48
    • 21
    • 12
    • 11
    • 10
    • 10
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Wirt
    • 52
    • 22
    • 1
    Maus
    Klonalität
    • 46
    • 29
    Monoklonal
    Konjugat
    • 26
    • 6
    • 5
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CDK5R1 Antikörper ist konjugiert mit Atto 390
    Applikation
    • 60
    • 43
    • 39
    • 21
    • 20
    • 13
    • 13
    • 12
    • 10
    • 10
    • 5
    • 3
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC), Antibody Array (AA)
    Spezifität
    Detects ~23 kDa.
    Kreuzreaktivität
    Huhn, Meerschweinchen, Human, Maus, Kaninchen, Saccharomyces cerevisiae
    Aufreinigung
    Protein G Purified
    Immunogen
    Recombinant human full length p23 protein
    Klon
    JJ6
    Isotyp
    IgG1
    Top Product
    Discover our top product CDK5R1 Primärantikörper
  • Applikationshinweise
    • WB (1:2000) IHC (1:100)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.
    Kommentare

    0.5 μg/ml of ABIN2486451 was sufficient for detection of p23 in 20 μg of heat shocked cell lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Conjugated antibodies should be stored at 4°C
  • Target
    CDK5R1 (Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35) (CDK5R1))
    Andere Bezeichnung
    p23 (CDK5R1 Produkte)
    Synonyme
    CDK5P35 antikoerper, CDK5R antikoerper, NCK5A antikoerper, p23 antikoerper, p25 antikoerper, p35 antikoerper, p35nck5a antikoerper, cdk5r1 antikoerper, zgc:92814 antikoerper, CDK5R1 antikoerper, Cdk5r antikoerper, P25/P35 antikoerper, D11Bwg0379e antikoerper, Xp35.1 antikoerper, cyclin dependent kinase 5 regulatory subunit 1 antikoerper, cyclin-dependent kinase 5, regulatory subunit 1b (p35) antikoerper, cyclin-dependent kinase 5 regulatory subunit 1 antikoerper, S100 calcium binding protein A9 antikoerper, cyclin-dependent kinase 5, regulatory subunit 1 (p35) antikoerper, cyclin-dependent kinase 5, regulatory subunit 1 (p35) L homeolog antikoerper, CDK5R1 antikoerper, cdk5r1b antikoerper, Cdk5r1 antikoerper, S100A9 antikoerper, cdk5r1.L antikoerper
    Hintergrund
    P23 is a highly conserved ubiquitous protein, known to have an important function as a cochaperone for the HSP90 chaperoning system (1). Studies have revealed that p23 is a small protein (18 to 25 kDa) with a simple structure (2, 3). p23 does not have any structural homology with any other known proteins (1). p23 was first discovered as a part of the HSP90-progesterone receptor complex along with HSP70, p54 and p50 (1). p23 is a phosphor-protein, which is highly acidic and has an aspartic acid-rich c-terminal domain (1). Numerous studies have found p23 to be associated with other client proteins like Fes tyrosine kinase (4), the heme regulated kinase HRI (5), hsf1 transcription factor (4), aryl hydrocarbon receptor (4), telomerase (6), and Hepadnavirus reverse transcriptase (7). In spite of several years of study, the exact functional significance of p23 is still not clear (8). p23 is thought to be involved in the adenosine triphosphate-mediated HSP90 binding of client proteins (8). Since many HSP90 client proteins are involved in oncogenic survival signaling, a recent study has concluded p23 to be a promising target in leukemic apoptosis (9). HSP90 and its co-chaperone p23 are certainly among the emerging anti-tumor targets in oncology.
    Gen-ID
    10728
    NCBI Accession
    NP_006592
    UniProt
    Q15185
    Pathways
    Stem Cell Maintenance, Regulation of Cell Size, Positive Regulation of Endopeptidase Activity
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