F4/80 Antikörper (AA 732-747)

Produktnummer ABIN1387314

Produktdetails anti-F4/80 Antikörper

Target: F4/80 (EMR1) (Egf-Like Module Containing, Mucin-Like, Hormone Receptor-Like 1 (EMR1))

Bindungsspezifität: AA 732-747

Reaktivität: Maus, Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser F4/80 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human EMR1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:100-1000
FCM 1:20-100
IHC-P 1:100-500
IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Referenzen für anti-F4/80 Antikörper (ABIN1387314)

Xue, Han, Ma, Wu, Qin, Liu, Hu, Hong, Hou: "Effect of Microenvironment on Differentiation of Human Umbilical Cord Mesenchymal Stem Cells into Hepatocytes In Vitro and In Vivo." in: BioMed research international, Vol. 2016, pp. 8916534, (2016) (PubMed).

Tsang, Huang, Yang, Chi, Chiang, Wang, Andocs, Szasz, Li, Chi: "Improving immunological tumor microenvironment using electro-hyperthermia followed by dendritic cell immunotherapy." in: BMC cancer, Vol. 15, pp. 708, (2015) (PubMed).

Kwan, Yeung, Liu, Wong, Shum, Lam, Cheng, Cheung, To: "Silver nanoparticles alter proteoglycan expression in the promotion of tendon repair." in: Nanomedicine : nanotechnology, biology, and medicine, Vol. 10, Issue 7, pp. 1375-83, (2014) (PubMed).

Details zu F4/80

Target: F4/80 (EMR1) (Egf-Like Module Containing, Mucin-Like, Hormone Receptor-Like 1 (EMR1))

Andere Bezeichnung: Emr1 (EMR1 Produkte)

Synonyme: EMR1 antikoerper, TM7LN3 antikoerper, DD7A5-7 antikoerper, EGF-TM7 antikoerper, F4/80 antikoerper, Gpf480 antikoerper, Ly71 antikoerper, adhesion G protein-coupled receptor E1 antikoerper, ADGRE1 antikoerper, LOC100424335 antikoerper, Adgre1 antikoerper

Hintergrund:

Synonyms: TM7LN3, EGF-like module-containing mucin-like hormone receptor-like 1, EGF-like module receptor 1, EMR1 hormone receptor, EMR1, Adhesion G Protein-Coupled Receptor E1, ADGRE1, Cell surface glycoprotein F4/80

Background: The epidermal growth factor (EGF)-TM7 family constitutes a group of class B G-protein coupled receptors, which includes CD97, EMR1 (EGF-like molecule containing mucin-like hormone receptor 1, designated F4/80 in mouse), EMR2, EMR3, FIRE, and ETL (13). These family members are characterized by an extended extracellular region with several N-terminal EGF domains, and are predominantly expressed on cells of the immune system (13). The EGF-TM7 protein family are encoded by a gene cluster on human chromosome 19p13 (1,3,4). The F4/80 Molecule is solely expressed on the surface of macrophages and serves as a marker for mature macrophage tissues, including Kupffer cells in liver, splenic red pulp macrophages, brain microglia, gut lamina propria, and Langerhans cells in the skin (1). F4/80/EMR1 undergoes extensive N-linked glycosylation as well as some O-linked glycosylation (5,6). The function of F4/80/EMR1 is unclear, but it is speculated to be involved in macrophage adhesion events, cell migration, or as a G-protein coupled signaling component of macrophages.

Gen-ID: 2015

UniProt: Q14246