IRF5
Reaktivität: Human
WB, IHC
Wirt: Kaninchen
Polyclonal
unconjugated
Applikationshinweise
ELISA. Western blot (1/500 - 1/1,000). Immunoprecipitation. Immunohistochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Konzentration
1.0 mg/mL
Buffer
PBS, pH 7.4, 0.09 % Sodium Azide
Konservierungsmittel
Thimerosal (Merthiolate)
Vorsichtsmaßnahmen
This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C/-20 °C
Informationen zur Lagerung
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Haltbarkeit
12 months
Idborg, Zandian, Ossipova, Wigren, Preger, Mobarrez, Checa, Sohrabian, Pucholt, Sandling, Fernandes-Cerqueira, Rönnelid, Oke, Grosso, Kvarnström, Larsson, Wheelock, Syvänen, Rönnblom, Kultima et al.: "Circulating Levels of Interferon Regulatory Factor-5 Associates With Subgroups of Systemic Lupus Erythematosus Patients. ..." in: Frontiers in immunology, Vol. 10, pp. 1029, (2019) (PubMed).
IRF-5 is a member of IRF family, which plays a critical role in the regulation of genes induced by viral infection, immunostimulation and cell growth regulation. The expression of IRF-5 is limited to lymphoid organs, dendritic cells, and peripheral blood lymphocytes, but is not expressed in numerous leukemia and lymphoma cell lines. Three IRFs(IRF-3, IRF-5, IRF-7) function as direct transducers of virus-mediated signaling and play a critical role in the expression of type I interferon genes and some chemokines.Synonyms: IRF-5, Interferon regulatory factor 5