F12 Antikörper (Light Chain)

Produktnummer ABIN111207

Produktdetails anti-F12 Antikörper

Target: F12 (Coagulation Factor XII (F12))

Bindungsspezifität: Light Chain

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser F12 Antikörper ist unkonjugiert

Applikation: Enzyme Immunoassay (EIA), Functional Studies (Func)

Spezifität: Reacts with the light chain of human Factor XII and at 100nM inhibits 50 % of Factor XII activity.

Aufreinigung: Protein G affinity chromatography

Immunogen: Purified human Factor XII

Klon: 802

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA, to detect/quantitate Factor XII and in coagulation assays.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.95 mg/mL

Buffer: PBS, pH 7.4, without preservative

Konservierungsmittel: Without preservative

Handhabung: Aliquot to Avoid multiple freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: Upon receipt, store at -20 °C to -70 °C.

Details zu F12

Target: F12 (Coagulation Factor XII (F12))

Abstract: F12 Produkte

Synonyme: HAE3 antikoerper, HAEX antikoerper, HAF antikoerper, FXII antikoerper, coagulation factor XII antikoerper, coagulation factor XII (Hageman factor) antikoerper, F12 antikoerper

Hintergrund: Coagulation factor XII circulates in blood as a zymogen. This single chain zymogen is converted to a two chain serine protease with an heavy chain (alpha factor XIIa) and a light chain. The heavy chain contains two fibronectin type domains, two epidermal growth factor (EGF) like domains, a kringle domain and a proline rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta factor XIIa light chain and the alpha factor XIIa light chain becomes beta factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha factor XIIa and then to beta factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in Factor XII gene do not cause any clinical symptoms and the sole effect is that whole blood clotting time is prolonged.Synonyms: HAF, Hageman factor

Gen-ID: 2161

NCBI Accession: NP_000496

UniProt: P00748

Pathways: Komplementsystem