F12 Produkte
(Coagulation Factor XII (F12))
Kategorien
This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged. [provided by RefSeq, Jul 2008].
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Ausgewählte F12 Kategorien
F12 Antikörper
High quality antibodies with extensive validation data.
F12 ELISA Kits
Reliable ELISA kits for a wide range of species.
F12 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene F12 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, IP, ICC
Validierungen
- (3)
Kat. Nr.
ABIN7432373
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Mouse
Applikation
WB, IHC, IP, ICC
Validierungen
- (3)
Kat. Nr.
ABIN7432376
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
ELISA, IHC, IP, IHC (p), IEP
Validierungen
- (3)
Kat. Nr.
ABIN364435
Menge
50 μg
Datenblatt
Datenblatt
Empfohlene F12 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
- (1)
Kat. Nr.
ABIN6954882
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6965907
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Rat
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6965909
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene F12 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1353299
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1353303
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Insect Cells
Validierungen
- (1)
Kat. Nr.
ABIN3079847
Menge
1 mg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren F12 Produkten
: "Neutralizing blood-borne polyphosphate in vivo provides safe thromboprotection." in: Nature communications, Vol. 7, pp. 12616, (2018) (PubMed).: "Ex vivo simulation of cardiopulmonary bypass with human blood for hemocompatibility testing." in: Perfusion, Vol. 31, Issue 5, pp. 376-83, (2016) (PubMed).
: "β-Eliminative depolymerization of the fucosylated chondroitin sulfate and anticoagulant activities of resulting fragments." in: Carbohydrate polymers, Vol. 127, pp. 427-37, (2015) (PubMed).
: "A Synthetic Factor XIIa Inhibitor Blocks Selectively Intrinsic Coagulation Initiation." in: ACS chemical biology, Vol. 10, Issue 8, pp. 1861-70, (2015) (PubMed).
: "Proteomic profiles in acute respiratory distress syndrome differentiates survivors from non-survivors." in: PLoS ONE, Vol. 9, Issue 10, pp. e109713, (2014) (PubMed).
: "Identification of target-binding peptide motifs by high-throughput sequencing of phage-selected peptides." in: Nucleic acids research, Vol. 42, Issue 22, pp. e169, (2014) (PubMed).
: "Variance decomposition of protein profiles from antibody arrays using a longitudinal twin model." in: Proteome science, Vol. 9, pp. 73, (2011) (PubMed).
: "Molecular mechanisms of thrombus formation in ischemic stroke: novel insights and targets for treatment." in: Blood, Vol. 112, Issue 9, pp. 3555-62, (2008) (PubMed).
: "Misfolded proteins activate factor XII in humans, leading to kallikrein formation without initiating coagulation." in: The Journal of clinical investigation, Vol. 118, Issue 9, pp. 3208-18, (2008) (PubMed).
: "The elusive physiologic role of Factor XII." in: The Journal of clinical investigation, Vol. 118, Issue 9, pp. 3006-9, (2008) (PubMed).
Synonyme und alternative Namen zu F12
coagulation factor XII (F12), coagulation factor XII (Hageman factor) (F12), FXII, HAE3, HAEX, HAFBezeichner auf Proteinebene für F12
- Hageman factor
- beta-factor XIIa part 1
- beta-factor XIIa part 2
- coagulation factor XII
- coagulation factor XIIa heavy chain
- coagulation factor XIIa light chain
- factor XII
- hageman factor
- HAF
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