ROCK2 Antikörper (N-Term)

Produktnummer ABIN1108892

Produktdetails anti-ROCK2 Antikörper

Target: ROCK2 (rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ROCK2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody detects ROCK2 (N-term).

Kreuzreaktivität (Details): Species reactivity (expected):MouseSpecies reactivity (tested):Human, rat

Aufreinigung: Immunogen affinity purified

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminal of human ROCK2 .Remarks: Sequence is identical to the related rat and mouse sequence.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Buffer: 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3.

Konservierungsmittel: Sodium azide, Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Sodium azide and Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the lyophilized product at -20 °C. Following reconstitution, the antibody can be stores at 2-8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu ROCK2

Target: ROCK2 (rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2))

Andere Bezeichnung: ROCK2 (ROCK2 Produkte)

Synonyme: rocka-a antikoerper, xROK antikoerper, rock2 antikoerper, rok2 antikoerper, ROCK2 antikoerper, B230113H15Rik antikoerper, ROKalpha antikoerper, Rho-kinase antikoerper, Rock-II antikoerper, Rock2m antikoerper, mKIAA0619 antikoerper, ROCK-II antikoerper, ROK antikoerper, Rho-associated, coiled-coil containing protein kinase 2 L homeolog antikoerper, rho-associated, coiled-coil containing protein kinase 2a antikoerper, Rho associated coiled-coil containing protein kinase 2 antikoerper, Rho-associated, coiled-coil containing protein kinase 2 antikoerper, Rho-associated coiled-coil containing protein kinase 2 antikoerper, rock2.L antikoerper, rock2a antikoerper, ROCK2 antikoerper, Rock2 antikoerper

Hintergrund: Rho-associated kinase (ROCK), including the ROCK-I and ROCK-II isoforms, is a protein kinase involved in signaling from Rho to actin cytoskeleton. Serine/threonine kinase ROCK II/Rho kinase, which is an isozyme of ROCK I, is one of the targets for the small GTPase Rho. ROCK II regulates the formation of actin stress fibers and focal adhesions, cytokinesis, smooth muscle contraction, and the activation of c-fos serum response element. Sequencing analysis has shown that human ROCK II contains 1388 amino acid residues with a calculated molecular mass of approximately 161 kDa. Fluorescence in situ hybridization analysis showed that the human ROCK II gene is located on chromosome 2p24.1 Thumkeo et al. (2003) concluded that ROCK-II is essential in inhibiting blood coagulation and maintaining blood flow in the endothelium-free labyrinth layer and that loss of ROCK-II leads to thrombus formation, placental dysfunction, intrauterine growth retardation, and fetal death.2Synonyms: KIAA0619, ROCK-2, Rho kinase 2, Rho-associated, Rho-associated protein kinase 2, coiled-coil-containing protein kinase 2, p164ROCK-2

Gen-ID: 9475

NCBI Accession: NP_004841

UniProt: O75116

Pathways: Microtubule Dynamics, WNT Signalweg, Tube Formation