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We conclude that while activation of muscle PGC-1beta is sufficient to drive the complete endurance phenotype in sedentary mice, it only partially prevents the detraining response following exercise training, suggesting that the process of endurance detraining involves mechanisms beyond the reversal of muscle autonomous mechanisms involved in endurance fitness.
Data suggest that PGC-1alpha (zeige PPARGC1A ELISA Kits) and -1beta expression are not required for training-induced exercise performance, highlighting the contribution of PGC-1 (zeige PPARGC1A ELISA Kits)-independent mechanisms.
We confirmed that PGC (zeige PGC ELISA Kits)-1b inhibited downstream inflammatory signals via binding with TAB1 (zeige TAB1 ELISA Kits) and thus preventing TAB1 (zeige TAB1 ELISA Kits)/TAK1 (zeige NR2C2 ELISA Kits) binding and TAK1 (zeige NR2C2 ELISA Kits) activation.
the anti-inflammatory environment in muscle promoted by the PGC (zeige PGC ELISA Kits)-1s might contribute to the beneficial effects of these coactivators on muscle function and provides a molecular link underlying the tight mutual regulation of metabolism and inflammation
PGC1beta represses proangiogenic genes and stimulates antiangiogenic genes in muscle ischemia. PGC1beta inhibits neoangiogenesis and blocks ischemic revascularization.
The data indicate a novel detrimental age-dependent role of PPAR beta (zeige PPARD ELISA Kits)/delta in Alzheimer disease by increasing pro-BDNF (zeige BDNF ELISA Kits) and decreasing BDNF (zeige BDNF ELISA Kits)/TrkB (zeige NTRK2 ELISA Kits) survival pathways.
The results highlight a novel function for SYVN1 (zeige SYVN1 ELISA Kits) in the control of body weight and mitochondrial biogenesis through negative regulation of PGC (zeige PGC ELISA Kits)-1b.
PGC-1beta in the gut (zeige GUSB ELISA Kits) acts as an adaptive self-point regulator, capable of providing a balance between enhanced mitochondrial activity and protection from increased ROS (zeige ROS1 ELISA Kits) production
Fisetin regulates the expression of hepatic lipid metabolism genes by downregulating miR (zeige MLXIP ELISA Kits)-378 and the host gene PGC-1beta.
Our aim was to assess the role of PGC-1 (zeige PPARGC1A ELISA Kits) coactivators during postnatal cardiac development and in adult hearts in mice.
The presence of the PPARGC1B (Ala203Pro) SNP did not modify the association between inorganic arsenic methylation capacity and breast cancer.
Genetic variants of PPARGC1B are significantly associated with gout, and a missense single nucleotide polymorphism, rs45520937, augments NLRP3 (zeige NLRP3 ELISA Kits) and IL-1beta (zeige IL1B ELISA Kits) expression
the forkhead box O3 (FOXO3 (zeige FOXO3 ELISA Kits))/liver kinase B1 (LKB1 (zeige STK11 ELISA Kits))/AMP-activated protein kinase (zeige PRKAA2 ELISA Kits)/peroxisome proliferator-activated receptor-gamma (zeige PPARG ELISA Kits) co-activator-1beta (PGC-1beta)/pyruvate dehydrogenase (zeige PDP ELISA Kits)-A1 pathway is essential for CD44 (zeige CD44 ELISA Kits) expression and cancer stem cells properties.
We also suggest a novel hepatic protective role of PGC1B as a modulator of E2 effects on mitochondrial biogenesis
we show an association of HER2 (zeige ERBB2 ELISA Kits)-overexpression and PGC-1beta. PGC-1beta knockdown impairs HER2 (zeige ERBB2 ELISA Kits)-overexpressing cells proliferation acting on ERRalpha (zeige ESRRA ELISA Kits) signaling, metabolism, and redox balance.
Further replication study confirmed the association signals of rs4705372 (P = 0.0026) and rs11743128 (P = 0.0387) in the independent validation sample. Our study results suggest that PPARGC1B is a novel susceptibility gene of Kashin-Beck disease .
Human influenza hemagglutinin (zeige HA ELISA Kits)-tagged PPARGC1B coprecipitated more intensely with ERalpha (zeige ESR1 ELISA Kits) in the +102525A than the +102525G construct after 17beta estradiol treatment
Data suggest that PGC-1alpha (zeige PPARGC1A ELISA Kits) and PGC-1beta could play a role in regulating retina cell survival, and may be therapeutic targets to prevent retinal degeneration.
PGC-1(beta) and estrogen-related receptor alpha (zeige ESRRA ELISA Kits) are aberrantly expressed in human colon cell lines and tumors.
RUNX3 (zeige RUNX3 ELISA Kits) is related to both the severity of AS and the function of daily life. PPARGC1B is related to the function of daily life.
The protein encoded by this gene stimulates the activity of several transcription factors and nuclear receptors, including estrogen receptor alpha, nuclear respiratory factor 1, and glucocorticoid receptor. The encoded protein may be involved in fat oxidation, non-oxidative glucose metabolism, and the regulation of energy expenditure. This protein is downregulated in prediabetic and type 2 diabetes mellitus patients. Certain allelic variations in this gene increase the risk of the development of obesity. Three transcript variants encoding different isoforms have been found for this gene.
peroxisome proliferator-activated receptor gamma, coactivator 1 beta
, peroxisome proliferator-activated receptor gamma coactivator 1-beta-like
, ERR ligand 1
, PPAR gamma coactivator-1beta protein
, PPAR-gamma coactivator 1-beta
, peroxisome proliferator-activated receptor gamma coactivator 1 beta
, peroxisome proliferator-activated receptor gamma coactivator 1-beta
, peroxisome proliferative activated receptor, gamma, coactivator 1 beta
, peroxisome proliferator-activated receptor gamma coactivator 1beta-2a
, PGC-1-related estrogen receptor alpha coactivator