anti-Werner Helicase Interacting Protein 1 (WRNIP1) Antikörper

Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). Zusätzlich bieten wir Ihnen WRNIP1 Kits (3) und WRNIP1 Proteine (3) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
WRNIP1 56897 Q96S55
WRNIP1 78903 Q91XU0
WRNIP1 282835 Q8CG07
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Top anti-WRNIP1 Antikörper auf antikoerper-online.de

Showing 10 out of 77 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-WRNIP1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: HepG2 cell lysate 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
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Human Ziege Unkonjugiert IHC, ELISA, WB   100 μg Anmelden zum Anzeigen 3 bis 4 Tage
349,82 €
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Human Kaninchen Unkonjugiert WB WB Image Sample (30 ug of whole cell lysate) A: A431 7.5% SDS PAGE antibody diluted at 1:1000 100 μL Anmelden zum Anzeigen 5 bis 7 Tage
357,24 €
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Rind (Kuh) Ziege Unkonjugiert EIA, WB   0.1 mg Anmelden zum Anzeigen 8 bis 11 Tage
357,50 €
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Human Kaninchen Unkonjugiert WB WRNIP1 Antibody (N-term)  western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the WRNIP1 antibody detected the WRNIP1 protein (arrow). 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
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Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), IP, WB Immunohistochemistry-Paraffin: WHIP Antibody [ABIN2588906] - FFPE section of human breast carcinoma. Affinity purified rabbit anti-WRNIP1 used at a dilution of 1:250. Western Blot: WHIP Antibody [ABIN2588906] - Whole cell lysate (5, 15 and 50 ug for WB; 1 mg for IP, 20% of IP loaded) from HeLa cells. Affinity purified rabbit anti-WRNIP1 antibody used for WB at 0.4 ug/ml (A) and 1 ug/ml (B) and used for IP at 3 ug/mg lysate. 100 μL Anmelden zum Anzeigen 2 bis 4 Tage
371,00 €
Details
Human Kaninchen Unkonjugiert ELISA, WB Western blot analysis is shown using Affinity Purified anti-Human WHIP antibody to detect Human WHIP present in a HEK293 whole cell lysate.  ~30µg of lysate was loaded per lane for 4-20% gradient SDS-PAGE.  Comparison to a molecular weight marker (not shown) indicates a primary band of ~96.0 kDa is detected.  The identity of the minor band migrating at a slightly higher molecular weight is unknown, but may represent an alternate isoform of WHIP or post translational modification of the WHIP protein.  See Figure 2 for the results of peptide competition experiments. The blot was incubated with a 1:200 dilution of the antibody at room temperature for 2 h followed by detection using IRDye® 800 labeled Goat-a-Rabbit IgG [H&L] MX10 (611-132-122) diluted 1:5,000 for 45 min.  IRDye® 800 fluorescence image was captured using the Odyssey® Infrared Imaging System developed by LI-COR. IRDye is a trademark of LI-COR, Inc.  Other detection systems will yield similar results. Western blot analysis is shown using antibodies-online's anti-Human WHIP antibody with and without pre-incubation with blocking peptide. Testing was performed on antiserum prior to affinity purification. Peptide competition (left) blocks the specific staining, whereas the control (right) shows staining of a strong dominant band corresponding to human WHIP1. ~30ug of HEK293 lysate was loaded per lane for 4-20% gradient SDS-PAGE. Comparison to a molecular weight marker (not shown) indicates a band of ~96.0 kDa is detected. The blot was incubated with a 1:1000 dilution of the antibody at room temperature for 2 h followed by detection using IRDye 100 μg Anmelden zum Anzeigen 5 bis 7 Tage
412,76 €
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Human Kaninchen Unkonjugiert EIA, IHC (p), WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
517,00 €
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Human Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 11 bis 14 Tage
600,64 €
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Human Ziege Unkonjugiert IHC, ELISA, WB 0.1 mg Anmelden zum Anzeigen 6 bis 8 Tage
505,48 €
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WRNIP1 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Mouse (Murine) , ,
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Rat (Rattus) , ,
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Am meisten referenzierte anti-WRNIP1 Antikörper

  1. Cow (Bovine) Polyclonal WRNIP1 Primary Antibody für WB - ABIN2775244 : Tsurimoto, Shinozaki, Yano, Seki, Enomoto: Human Werner helicase interacting protein 1 (WRNIP1) functions as a novel modulator for DNA polymerase delta. in Genes to cells : devoted to molecular & cellular mechanisms 2005 (PubMed)

  2. Human Polyclonal WRNIP1 Primary Antibody für IHC, ELISA - ABIN184613 : Kawabe Yi, Branzei, Hayashi, Suzuki, Masuko, Onoda, Heo, Ikeda, Shimamoto, Furuichi, Seki, Enomoto: A novel protein interacts with the Werner's syndrome gene product physically and functionally. in The Journal of biological chemistry 2001 (PubMed)

Weitere Antikörper gegen WRNIP1 Interaktionspartner

Human Werner Helicase Interacting Protein 1 (WRNIP1) Interaktionspartner

  1. WRNIP1 connects PCNA (zeige PCNA Antikörper) monoubiquitination with ATMIN (zeige ATMIN Antikörper)/ATM (zeige ATM Antikörper) to activate ATM (zeige ATM Antikörper) signalling in response to replication stress and contribute to the maintenance of genomic stability.

  2. The authors show that WRNIP1 is directly involved in preventing uncontrolled MRE11 (zeige MRE11A Antikörper)-mediated degradation of stalled replication forks by promoting RAD51 (zeige RAD51 Antikörper) stabilization on ssDNA.

  3. We propose that UBZ domains can be divided into at least two different types in terms of the ubiquitin-binding surfaces: the pol type and the WRNIP1 type

  4. results suggest that WRNIP1 functions upstream of Poleta in the response to UV irradiation

  5. Mutated WRNIP1 with a deleted ATPase (zeige DNAH8 Antikörper) domain or with mutations in lysine residues accumulated in laser light irradiated sites, suggesting that the ATPase (zeige DNAH8 Antikörper) domain of WRNIP1 and ubiquitination of WRNIP1 are dispensable for the accumulation.

  6. WHIP was identified as a partner/component of the nuclear envelope/nuclear pore complex (NPC (zeige NPC1 Antikörper)) and set forth to investigate a role for the protein positioned at the NPC (zeige NPC1 Antikörper).

  7. These results indicate that WRNIP1 functions as a modulator for initiation or restart events during pol delta (zeige POLD1 Antikörper)-mediated DNA synthesis and that its ATPase (zeige DNAH8 Antikörper) activity is utilized to sense DNA ends and to regulate the extent of stimulation.

  8. Werner helicase-interacting protein 1 binds polyubiquitin (zeige UBB Antikörper) via its zinc finger domain

  9. analysis of the composite and regulated topography of Wrnip1 in the human nucleus highlights its potential role in replication and other nuclear transactions

  10. Data show that that WRNIP1 interacts physically with RAD18 (zeige RAD18 Antikörper) and interferes with the binding of RAD18 (zeige RAD18 Antikörper) to forked DNA and to template/primer DNA.

Mouse (Murine) Werner Helicase Interacting Protein 1 (WRNIP1) Interaktionspartner

  1. Mutations in the Walker A motifs of the two proteins revealed that WRNIP1, but not WRN, must bind ATP before an efficient interaction can occur.

WRNIP1 Antigen-Profil

Protein Überblick

Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene.

Genbezeichner und Symbole assoziert mit WRNIP1

  • Werner helicase interacting protein 1 (WRNIP1) Antikörper
  • Werner helicase interacting protein 1 (wrnip1) Antikörper
  • ATPase WRNIP1 (EDI_075920) Antikörper
  • ATPase WRNIP1 (CpipJ_CPIJ017857) Antikörper
  • ATPase WRNIP1 (PITG_07216) Antikörper
  • ATPase WRNIP1 (VDBG_02914) Antikörper
  • ATPase WRNIP1 (PGTG_08805) Antikörper
  • Werner helicase interacting protein 1 (Wrnip1) Antikörper
  • WRNIP1 protein (LOC100155921) Antikörper
  • 4833444L21Rik Antikörper
  • bA420G6.2 Antikörper
  • RP11-420G6.2 Antikörper
  • Whip Antikörper
  • Wrnip Antikörper
  • wrnip1 Antikörper
  • zgc:85976 Antikörper

Bezeichner auf Proteinebene für WRNIP1

Werner helicase interacting protein 1 , ATPase WRNIP1 , Werner helicase-interacting protein 1 , putative helicase RUVBL , Werner helicasae interacting protein 1 , Werner syndrome homolog interacting protein , werner helicase-interacting protein 1

GENE ID SPEZIES
462392 Pan troglodytes
707250 Macaca mulatta
734231 Xenopus laevis
782711 Bos taurus
395089 Gallus gallus
100158593 Xenopus (Silurana) tropicalis
5882536 Entamoeba dispar SAW760
6052914 Culex quinquefasciatus
9471556 Phytophthora infestans T30-4
9532917 Verticillium alfalfae VaMs.102
10529992 Puccinia graminis f. sp. tritici CRL 75-36-700-3
100595079 Nomascus leucogenys
56897 Homo sapiens
405856 Danio rerio
788824 Bos taurus
78903 Mus musculus
282835 Rattus norvegicus
100155921 Sus scrofa
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