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TPBG encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. Zusätzlich bieten wir Ihnen TPBG Antikörper (58) und TPBG Kits (5) und viele weitere Produktgruppen zu diesem Protein an.
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In conclusion, the present study provided evidence that TPBG is involved in PDAC metastasis, and that TPBG and its associated signaling pathways may be a suitable target for pancreatic ductal adenocarcinoma therapy.
5T4 expression is mechanistically associated with the directional movement of cells through epithelial mesenchymal transition, facilitation of CXCL12 (zeige CXCL12 Proteine)/CXCR4 (zeige CXCR4 Proteine) chemotaxis, blocking of canonical Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) while favouring non-canonical pathway signalling
Tyrosine 325 plus the leucine-rich repeat 1 surface centered on a second exposed aromatic residue, phenylalanine 97, are essential for inhibition of Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling.
The surface expression of 5T4 marks the use of the CXCR4 (zeige CXCR4 Proteine) rather than the CXCR7 receptor, with distinct consequences for CXCL12 (zeige CXCL12 Proteine) exposure.
5T4 is a potential new antigen for targeted therapies such as immunotherapy in MPM, as it is overexpressed on mesothelioma cells and recognised by 5T4-specific cytotoxic T-cells.
Glycosylation and epitope mapping of the 5T4 glycoprotein oncofoetal antigen
Results sugest that 5T4 is a transient marker of human embryonic stem cell differentiation & that 5T4 phenotype, colony seeding density and culture conditions influence the maintenance of pluripotent hES (zeige RRBP1 Proteine) cells and their differentiation to neural lineages.
there is a repertoire of CD8 T cell recognition of 5T4 in normal human donors and some candidate HLA-A*0201 epitopes have been identified
the mRNA expression of trophoblast glycoprotein is up-regulated in cells circulating within blood from women with preeclampsia.
5T4-based cancer vaccine: cytotoxic T lymphocyte epitopes identified in Trovax-vaccinated colorectal cancer patients
5T4 overexpression in newborn olfactory bulb interneurons facilitates their dendritic arborization even under a sensory input-deprived condition.
molecular interaction of 5T4 and CXCR4 (zeige CXCR4 Proteine) occurring at the cell surface which directly facilitates the biological response to CXCL12 (zeige CXCL12 Proteine)
Spry4 (zeige SPRY4 Proteine) and Tpbg/5T4 were detected in Kit-immunoreactive cells only in Kit(K641E), but not in Kit(WT/WT) animals.
5T4 glycoprotein expression is associated with early differentiative events of embryonic stem cells
A limited expression profile of 5T4 may contribute to the migration of actively cycling, undifferentiated epithelial progenitor cells during embryogenesis
Because 5T4 is known to interact with actin cytoskeleton, these observations suggest that 5T4 is involved in the formation or maintenance of strata-specific dendritic ramification or synaptic connection of subsets of local interneurons.
E-cadherin (zeige CDH1 Proteine) protein stabilizes cortical actin cytoskeletal arrangement in embryonic stem cells, and this can prevent cell surface localization of the promigratory 5T4 antigen.
This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein.
, 5T4 oncofetal trophoblast glycoprotein
, Trophoblast glycoprotein
, trophoblast glycoprotein-like
, 5T4 oncofetal antigen
, 5T4 oncotrophoblast glycoprotein