Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Zusätzlich bieten wir Ihnen TRPM8 Proteine (9) und TRPM8 Kits (2) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 159 products:
Fruit Fly (Drosophila melanogaster) Polyclonal TRPM8 Primary Antibody für ICC, IHC (fro) - ABIN152287
Peabody, Pohl, Diao, Vreede, Sandstrom, Wang, Zelensky, White: Characterization of the decision network for wing expansion in Drosophila using targeted expression of the TRPM8 channel. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2009
Show all 2 Pubmed References
Human Polyclonal TRPM8 Primary Antibody für ELISA - ABIN451742
Dhaka, Murray, Mathur, Earley, Petrus, Patapoutian: TRPM8 is required for cold sensation in mice. in Neuron 2007
Human Polyclonal TRPM8 Primary Antibody für ICC, IF - ABIN4362970
Wang, Yu, Yan, Lei, Chai, Jiang, Yuan, Xing, Du: TRPM8 in the negative regulation of TNFα expression during cold stress. in Scientific reports 2017
The role of TRPM8 in the Guinea-pig bladder-cooling reflex investigated using a novel TRPM8 antagonist
our results indicate that enhanced TRPM8 hydrolysis in prostate cancer could present an adaptation mechanism, sustained via bypassing testosterone-induced rapid Ca2 (zeige CA2 Antikörper)+ uptake through TRPM8, thus, diminishing the rates of apoptosis
Suggest a novel, pore-independent molecular mechanism by which endogenous TRPM8 expression inhibits Rap1 (zeige RABGEF1 Antikörper) GTPase (zeige RACGAP1 Antikörper) and thus plays a critical role in the behavior of vascular endothelial cells by inhibiting migration.
in this study, the glycosylation status of the TRPM8 channel was shown to affect cell proliferation, cell migration, and calcium uptake. TRPM8 expressed in the membrane of the Panc-1 pancreatic tumoral cell line is non-glycosylated, whereas human embryonic kidney cells transfected with human TRPM8 overexpress a glycosylated protein.
This study demonstrates that TRPM8 (cold receptor) is present in nasal epithelium. When it is activated by moderate cooling at 24 degrees C or menthol, TRPM8 induces the secretion of mucin (zeige SLC13A2 Antikörper). This study determines that TRPM8 channels are important regulators of mucin (zeige SLC13A2 Antikörper) production. Therefore, TRPM8 antagonists could be used for the treatment of refractory rhinitis.
This study suggests that the TRPM8 sensor is a key determinant of germ cell fate under hypothermic stimulation.
TRPM8 SNPs are significantly associated with the risk of COPD in the Chinese Han population.
TRPM8 activation is likely to occur when cigarettes contain more than 50 micrograms of menthol.
This review outlines our current understanding on the role of TRPM8 in occurrence and development of different kinds of tumor and also includes discussion about the regulation of TRPM8 during carcinogenesis as well as therapeutic potential of targeting TRPM8 in tumor, which may be utilized for a potential pharmacological use as a target for anti-cancer therapy.[review]
The effects of specific agents on TRPV1 (zeige TRPV1 Antikörper) and TRPM8 channels are intricately interrelated.
The data of this study provided evidence for decreased activity and expression level of TRPM8 in the presence of methylglyoxal.
The results of this study show that chronic morphine upregulates TRPM8 channels, which is in contrast with the previous finding that acute morphine triggers TRPM8 internalization.
data suggest that sex differences in the functioning of Ih and Ik in TRPM8 expressing primary afferent neurons leads to differences in cool temperature sensitivity
We identify PLCdelta4 as a PLC (zeige HSPG2 Antikörper) isoform important in the regulation of TRPM8 both at the cellular level and in vivo
Reduced functional expression of TRPM8 in sensory neurons (due to VAMP7 (zeige VAMP7 Antikörper) knockout) is associated with deficits in cold avoidance and icilin-induced cold hypersensitivity.
Report essential role of skin TRPM8 in a model of acute cold-induced urinary urgency.
This study findings suggest the existence of VGLUT2 (zeige SLC17A6 Antikörper) (but not VGLUT1 (zeige SLC17A7 Antikörper))-mediated glutamate (zeige GRIN1 Antikörper) signaling in TRPM8+ neurons possibly underlying the cold-induced acute pain and hypersensitivity to cold following pulpal inflammation.
Data suggest that blockage of transient receptor potential (TRP) channels TRPA1 (zeige TRPA1 Antikörper), TRPV4 (zeige TRPV4 Antikörper) and possibly TRPM8 may represent a therapeutic option for patients with colonic discomfort and pain.
TRPM8 signaling in mucosal sensory neurons is indispensable for the regulation of innate inflammatory responses via the neuropeptide CGRP (zeige CALCA Antikörper).
TRPM8-expressing dural afferent fibers undergo cell- and target tissue-specific axonal pruning during postnatal development.
Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.
transient receptor potential cation channel, subfamily M, member 8
, transient receptor potential cation channel subfamily M member 8b
, transient receptor potential cation channel subfamily M member 8
, transient potential cation channel subfamily M member 8
, long transient receptor potential channel 6
, short form of the TRPM8 cationic channel
, transient receptor potential p8
, transient receptor potential subfamily M member 8
, TRP ion channel TRPM8
, transient receptor potential-p8
, cold menthol receptor 1
, cold/menthol receptor 1
, menthol receptor
, transient receptor potential M8 protein
, transient receptor potential cation channel, subfamily M, member 8 (predicted), 3 prime
, transient receptor potential cation channel, subfamily M, member 8 (predicted), 5 prime